Shift in age in chickenpox

Miller, Elizabeth; Vurdien, J.; Farrington, Paddy

doi:10.1016/0140-6736(93)92663-e

Cited by 81 publications

(36 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Furthermore, the characteristic hill is also present in both countries, whereas the patients in Germany are much younger (mean 7.4 years, median=mode 5 years) than in United Kingdom (mean 14.2 years, median=mode 9 years). This has to be seen in the light of age-shift observed in United Kingdom [8] during the last 25 years [18,23]. A similar trend was recognised in the United States by analysing the complications and mortality rates of varicella cases [7,17].…”

Section: Discussionmentioning

confidence: 61%

Can varicella be eliminated by vaccination? Potential clinical and economic effects of universal childhood varicella immunisation in Germany

Wutzler

Neiss²,

Banz³

et al. 2002

Medical Microbiology and Immunology

View full text Add to dashboard Cite

Varicella is a potentially serious infection not only in immunocompromised individuals but also in otherwise healthy adults and children. Vaccination plays an important role in preventing the disease and its sequelae. A universal vaccination in childhood is expected to reduce substantially the number of uncomplicated cases of varicella and decrease the number of complicated cases requiring hospitalisation. To generate data as basis for decisions of the health authorities concerning prevention of varicella, epidemiological and health-economic data were collected in two studies. Using an age-structured decision analytic model the benefits, costs and cost effectiveness of a varicella immunisation program for a period of 30 years were assessed. It was shown that after the first year of life seroprevalence rates increased steadily and reached 62% among the 4- to 5-year olds and 94% among the 10- to 11-year olds, respectively; 90% of varicella patients were younger than 12 years. A severe course was assessed for 16.3% of the cases. Overall incidence of complications was estimated to be 5.7%. A routine varicella vaccination program targeting healthy children could prevent 82.7% of varicella cases and over 4,700 major complications per year provided the coverage level was 85%. Under these conditions the elimination of varicella is predicted to be achievable within 18 years. It is expected that a combined measles, mumps, rubella and varicella vaccine could provide the required coverage. Average yearly discounted net cost savings of universal childhood vaccination are 51 million Euro with a benefit-cost ratio of 4.12. Childhood vaccination with catch-up of adolescents provides additional clinical benefits. The break-even point indicating first net savings could be achieved already 3 years after the implementation of the vaccination program. In summary, routine childhood varicella vaccination appears to be a highly efficient strategy to significantly reduce the sizeable burden of varicella and would lead to net savings from both the societal but also the payer perspective.

show abstract

Section: Discussionmentioning

confidence: 61%

Can varicella be eliminated by vaccination? Potential clinical and economic effects of universal childhood varicella immunisation in Germany

Wutzler

Neiss²,

Banz³

et al. 2002

Medical Microbiology and Immunology

View full text Add to dashboard Cite

show abstract

“…During the last two decades, an increase in susceptibility among young adults has been observed in the United States (pre-vaccination period) and the UK, but the reason for this change is unclear [11,16,28]. Furthermore, although there is evidence of an upward shift in the age-distribution of cases among young adults, a decrease over time in the average age of chickenpox infections in the UK was simultaneously observed and seems related to changing mixing patterns (e.g.…”

Section: Discussionmentioning

confidence: 99%

The seroepidemiology of primary varicella-zoster virus infection in Flanders (Belgium)

Thiry

Beutels

Shkedy

et al. 2002

European Journal of Pediatrics

View full text Add to dashboard Cite

since varicella-zoster virus predominantly affects very small children and is generally perceived as benign, the required high coverage rate of a universal childhood varicella vaccination programme may be hard to attain. Adolescent strategies can minimise the population risks involved but the accuracy of non positive antecedents of chickenpox needs to be documented to assess the efficiency of such strategies.

show abstract

“…Tendo em vista o risco da varicela em adultos e adolescentes, é preocupante a observação, em diversos inquéritos epidemiológicos recentes, de uma mudança no padrão da infecção pelo VZV em alguns países desenvolvidos ou em desenvolvimento, com um aumento na incidência da doença em indivíduos de maior idade [4][5][6] . Além disso, parecem existir diferenças na epidemiologia da varicela entre locais de clima temperado e tropical, com países tropicais tendo uma menor prevalência e um maior número de casos em adolescentes e adultos [7][8][9] .…”

unclassified

Soroepidemiology of Varicella in Brazil - results of a prospective cross-sectional study

Clemens¹,

Azevedo²,

Fonseca³

et al. 1999

J Pediatr (Rio J)

View full text Add to dashboard Cite

ResumoObjetivos: A varicela tem conseqüências mais graves em adolescentes e adultos. Recentes relatos da Europa e da Ásia mostram um número crescente de adolescentes e adultos jovens soronegativos. Como são poucos os dados sobre a prevalência de anti-VZV no Brasil e com o objetivo de definir estratégias para a imunização contra a varicela, realizamos um estudo de soroprevalência para o VZV (vírus varicela zoster) em diferentes partes do Brasil.Métodos: Este estudo soroepidemiológico, transversal e populacional foi realizado em quatro diferentes regiões do Brasil. A população estudada foi estratificada por sexo, idade e situação socioeconômica. Anticorpos Ig G, anti-VZV foram analisados pelo método ELISA.Resultados: Foram incluídos no estudo 3.879 indivíduos de 1 a 40 anos. A taxa de soropositividade do anti-VZV em todos os grupos etários e centros no Brasil foi de 85,4 %. Evidenciou-se uma forte correlação com a idade. Especialmente no Sudeste e Sul, a soroprevalência foi menor no grupo etário de 1-5 anos (44,5% e 57,8%, respectivamente). Na região Norte esta taxa foi de 88,9%. No geral, a infecção pelo VZV foi independente do nível socioeconômico, entretanto nos grupos etários jovens (1-10 anos) a soroprevalência foi significativamente menor nas classes alta/média, na maioria das regiões. A história clínica de varicela se correlacionou com a soropositividade anti-VZV, tendo um valor preditivo de 95,1%.Conclusões: Na pré-adolescência, uma proporção substancial da população brasileira é susceptível à varicela e uma parcela considerável de adolescentes e adultos jovens permanecem soronegativos e, conseqüentemente, em risco. AbstractObjectives: Varicella has more serious consequences in adolescents and adults. Recent reports from Europe and Asia show an increasing number of adolescents and young adults being seronegative. As there is only limited data on varicella zoster virus (VZV) seroprevalence in Brazil and to facilitate the strategy for varicella vaccination we conducted a VZV seroprevalence study in Brazil.Methods: This population-based, cross sectional seroepidemiology study was performed in 4 different regions of Brazil. The studied population was stratified according to gender, age and socioeconomic status. VZV IgG antibodies were analyzed by ELISA.Results: 3,879 subjects aged 1-40 years were included into the study. The overall anti-VZV seropositivity rate across all age groups and centers in Brazil was 85.4%. There was a strong age relationship. Especially in the South East and South seroprevalence was low in the age group 1-5 years (44.5% and 57.8%, respectively) while in the North the rate was 88.9%. Overall, Varicella infection was independent of the socioeconomic level, but in the youngest age groups (1-10 years) seroprevalence rates were significantly lower in the high/medium socioeconomic class for most regions. Clinical history of chickenpox correlates well with anti-VZV seropositivity with a predictive value of 95.1%Conclusions: In preadolescence a substantial proportion of the Brazilian populat...

show abstract

Shift in age in chickenpox

Cited by 81 publications

References 2 publications

Can varicella be eliminated by vaccination? Potential clinical and economic effects of universal childhood varicella immunisation in Germany

Can varicella be eliminated by vaccination? Potential clinical and economic effects of universal childhood varicella immunisation in Germany

The seroepidemiology of primary varicella-zoster virus infection in Flanders (Belgium)

Soroepidemiology of Varicella in Brazil - results of a prospective cross-sectional study

Contact Info

Product

Resources

About