During the early design stage of an underwater vehicle, the correct assessment of its manoeuvrability is a crucial task. Conducting experimental tests still has high costs, especially when dealing with small vehicles characterized by low available budget. In the current investigation, virtual towing tank tests are simulated using the open-source OpenFOAM library in order to assess the reliability of CFD methods for the prediction of hydrodynamic forces and moments. A well-known case study, the Defence Advanced Research Projects Agency (DARPA) SUB-OFF model, is used, and the outcomes are compared to the experimental results available in the literature. Five different configurations are investigated for pure drift tests, rudder tests and pure rotation in both vertical and horizontal plane. The results show an overall good agreement with the experimental data with a quite low demanding mesh arrangement of 3M cells, a favourable balance between accuracy and computational time. In more detail, the expected error in the most significant forces during manoeuvres is less than 2% for the fully appended configuration (the submarine real operative condition), whereas the accuracy is moderately reduced for the barehull configuration (a case not representative of a real hull) with an expected error of 15%. A possible reason for the differences observed could be attributed to the description of the two streamwise vortices generated when manoeuvring. Apart from the lateral force and yaw moment, the results of the longitudinal force are also presented, having a greater disparity when compared to the experimental data. Nevertheless, the longitudinal force has no important role for the purpose of making stability and control predictions. The study contributes to the validation and consolidation of CFD methods, offering insights into their accuracy and limitations for practical applications in underwater vehicles.