Short and Long Term Effects of Influenza a on Lung Function

Ledder, S R; Gill, Paneet; Peat, J. K.

doi:10.5694/j.1326-5377.1974.tb71201.x

Cited by 12 publications

(5 citation statements)

References 8 publications

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“…Measurement of midexpiratory flow rates and newer tests of the function of small airways may be more sensitive for detecting the effects of viral infections on pulmonary function in normal adults [15][16][17]19]. However, these tests are apparently of little value in detecting changes after viral infections [17] or in following the course of the illness in patients with established obstruction of airways [37,38].…”

Section: Discussionmentioning

confidence: 99%

“…Long-term effects of influenza or other viral infections on the course of chronic obstructive pulmonary disease were not detected in this study population.The hypothesis that viral infections of the respiratory tract may contribute to progressive deterioration of airway function in patients with chronic bronchitis, emphysema, and other chronic obstructive pulmonary diseases (COPD) has intrigued investigators for several years [1][2][3][4][5]. Evidence supporting this hypothesis includes the well-documented association between viral infections and acute exacerbations of bronchitis in patients with COPD [5][6][7][8][9][10][11][12], as well as the recent reports that transient alterations in the function of small airways may occur in normal adults after acute viral infections of the respiratory tract [13][14][15][16][17][18][19].…”

mentioning

confidence: 99%

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Effect of Viral Infections on Pulmonary Function in Patients with Chronic Obstructive Pulmonary Diseases

Smith

Kanner

Golden

et al. 1980

Journal of Infectious Diseases

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The effect of 100 separate viral infections of the respiratory tract on pulmonary function was evaluated prospectively over an eight-year period in 84 patients with chronic obstructive pulmonary diseases and in eight normal subjects. Some viral infections were associated with small acute declines in forced vital capacity and/or 1-sec forced expiratory volume of 25-300 ml. These declines were detectable only during the 90-day period after infection. The greatest abnormalities of pulmonary function followed infections with influenza virus, and the mean acute changes in 1-sec forced expiratory volume (-118.5 ml) were significantly greater than expected (-15.2 ml; P = 0.03). Smaller, statistically insignificant declines followed infections with parainfluenza virus, rhinovirus, adenovirus, and respiratory syncytial virus, and no changes were detectable after infections with coronavirus, herpes simplex virus, Mycoplasma pneumoniae, and Haemophilus influenzae. Long-term effects of influenza or other viral infections on the course of chronic obstructive pulmonary disease were not detected in this study population.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Effect of Viral Infections on Pulmonary Function in Patients with Chronic Obstructive Pulmonary Diseases

Smith

Kanner

Golden

et al. 1980

Journal of Infectious Diseases

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“…Infected lungs were more dif®cult to in¯ate with air, mainly due to an increase in surface forces indicating disruption of lung surfactant. Impairment of ventilation has also been suggested to be the cause of hypoxaemia in viral pneumonia [15]. In view of these previous studies, it seemed likely that in our model of pneumonia, which is fatal within 8±10 days, there would almost certainly be substantial and detectable lung dysfunction.…”

Section: Discussionmentioning

confidence: 78%

Plethysmography for the assessment of pneumococcal pneumonia and passive immunotherapy in a mouse model

Hennezel¹,

Debarre²,

Ramisse³

et al. 2001

Eur Respir J

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The increasing prevalence of resistance to antibiotics of Streptococcus pneumoniae, the main causative agent of community-acquired bacterial pneumonia, necessitates the development of both new therapeutic strategies and noninvasive methods in order to evaluate their efficacy. The efficacy of passive immunotherapy with human intravenous immunoglobulin (IVIG) or solvent alone, administered intranasally or intravenously, was evaluated in a mouse model of acute pneumonia. Lung bacterial load was also evaluated, using a classical but invasive method, as was respiratory function (minute ventilation, respiratory frequency and tidal volume) using plethysmography, a simple noninvasive method commonly used in inhalation toxicology, but not previously used to assess respiratory infection. Forty-eight hours after infectious challenge, the lung bacterial load was significantly lower in IVIG-treated mice than in untreated mice. At the same time, minute ventilation was significantly lower than reference values for untreated mice (36+/-3 versus 57+/-8 mL.min(-1), p<0.01, and 31+/-2 versus 50+/-5 mL.min(-1), p<0.01 for intranasal and intravenous administration of solvent, respectively) but not in mice treated with IVIG by either route of administration. Plethysmography therefore appears to be a simple and reliable test for the follow-up of acute respiratory infection.

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“…Acute influenza A induced gas transport abnormality in the lung for up to 6 months in healthy adults, although resolution was documented in all survivors [ 15 ]. Small-airway flow also was temporarily reduced in acute influenza, while other spirometric measures of pulmonary function were unaffected [ 16 ]. Caution should be taken in making direct comparisons between hantavirus pneumonitis and other viral pneumonitides because, unlike the infected epithelial cells seen in influenza pneumonitis, acute hantavirus pneumonitis is characterized by an intense viral infection of pulmonary capillary endothelial cells [ 2 ].…”

Section: Discussionmentioning

confidence: 99%

Convalescent Pulmonary Dysfunction Following Hantavirus Pulmonary Syndrome in Panama and the United States

Gracia¹,

Armién

Simpson

et al. 2010

Lung

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The objective of this study was to document persistent pulmonary symptoms and pulmonary function abnormalities in adults surviving hantavirus pulmonary syndrome (HPS). Acute infection by most hantaviruses result in mortality rates of 25–35%, while in Panama the mortality rate of 10% is contrasted by an unusually high incidence. In all types of HPS, the viral prodrome, cardiopulmonary phase due to massive pulmonary capillary leak syndrome, and spontaneous diuresis are followed by a convalescent phase with exertional dyspnea for 3–4 weeks, but the frequency of persistent symptoms is not known. In this observational study of a convenience sample, 14 survivors of HPS caused by Choclo virus infection in Panama and 9 survivors of HPS caused by Sin Nombre virus infection in New Mexico completed a questionnaire and pulmonary function tests up to 8 years after infection. In both groups, exertional dyspnea persisted for 1–2 years after acute infection in 43% (Panama) and 77% (New Mexico) of survivors surveyed. Reduction in midexpiratory flows (FEF25–75%), increased residual volume (RV), and reduced diffusion capacity (DLCO/VA) also were common in both populations; but the severity of reduced expiratory flow did not correlate with exertional dyspnea. Symptoms referable to previous hantavirus infection had resolved within 3 years of acute infection in most but not all patients in the Panama group. Temporary exertional dyspnea and reduced expiratory flow are common in early convalescence after HPS but resolves in almost all patients.

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Short and Long Term Effects of Influenza a on Lung Function

Cited by 12 publications

References 8 publications

Effect of Viral Infections on Pulmonary Function in Patients with Chronic Obstructive Pulmonary Diseases

Effect of Viral Infections on Pulmonary Function in Patients with Chronic Obstructive Pulmonary Diseases

Plethysmography for the assessment of pneumococcal pneumonia and passive immunotherapy in a mouse model

Convalescent Pulmonary Dysfunction Following Hantavirus Pulmonary Syndrome in Panama and the United States

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