Short- and long-term effects of a neonatal low-protein diet in rats on the morphology of the larynx

Pires-de-Mélo, Iracema Hermes; Reis, Flávia Wanderley dos; Luz, Lívia Silva; Paz, Silvânia Tavares; Silva, Hilton Justino; Souza, Sandra Lopes de; Leandro, Carol Góis

doi:10.1016/j.nut.2008.12.015

Cited by 9 publications

(3 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is well established that LP intake, reduced FC and body weight gain during pregnancy/lactation are the three main factors influencing maternal and infant outcomes ( 31 – 33 ) . In fact, we have demonstrated that protein restriction during gestation produces intra–uterine growth restriction and continued protein restriction during lactation counteracts catch up growth and results in long-term decreases in body weight due to a reduction in both lean and fat mass ( 2 , 33 , 34 ) . The underlying probable mechanism of the deficit in an offspring’s growth patterns can be associated to hormonal alterations, such as reduced insulin-like growth factor-1 ( 35 ) concentration and growth hormone mRNA expression ( 36 ) .…”

Section: Discussionmentioning

confidence: 99%

Effects of high-fat diet on somatic growth, metabolic parameters and function of peritoneal macrophages of young rats submitted to a maternal low-protein diet

et al. 2017

Self Cite

View full text Add to dashboard Cite

This study evaluated the effects of a post-weaning high-fat (HF) diet on somatic growth, food consumption, metabolic parameters, phagocytic rate and nitric oxide (NO) production of peritoneal macrophages in young rats submitted to a maternal low-protein (LP) diet. Male Wistar rats (aged 60 d) were divided in two groups (n 22/each) according to their maternal diet during gestation and lactation: control (C, dams fed 17 % casein) and LP (dams fed 8 % casein). At weaning, half of the groups were fed HF diet and two more groups were formed (HF and low protein-high fat (LP-HF)). Somatic growth, food and energy intake, fat depots, serum glucose, cholesterol and leptin concentrations were evaluated. Phagocytic rate and NO production were analysed in peritoneal macrophages under stimulation of zymosan and lipopolysaccharide (LPS)+interferon γ (IFN-γ), respectively. The maternal LP diet altered the somatic parameters of growth and development of pups. LP and LP-HF pups showed a higher body weight gain and food intake than C pups. HF and LP-HF pups showed increased retroperitoneal and epididymal fat depots, serum level of TAG and total cholesterol compared with C and LP pups. After LPS+IFN-γ stimulation, LP and LP-HF pups showed reduced NO production when compared with their pairs. Increased phagocytic activity and NO production were seen in LP but not LP-HF peritoneal macrophages. However, peritoneal macrophages of LP pups were hyporesponsive to LPS+IFN-γ induced NO release, even after a post-weaning HF diet. Our data demonstrated that there was an immunomodulation related to dietary fatty acids after the maternal LP diet-induced metabolic programming.

show abstract

Section: Discussionmentioning

confidence: 99%

Effects of high-fat diet on somatic growth, metabolic parameters and function of peritoneal macrophages of young rats submitted to a maternal low-protein diet

et al. 2017

Self Cite

View full text Add to dashboard Cite

show abstract

“…The body weight of pups was weekly recorded all through the experiment with a Marte Scale, AS-1000, approaching 0.01 g. The body length of pups was recorded on days 21-63 of life by measuring the external surfaces (nose-to-anus length) using a digital caliper (0.01 mm accuracy). The body weight and body length were used to determine the body mass index (BMI, grams/lengh 2 ) [ 17 ] .…”

Section: Off Spring Body Weight and Body Lengthmentioning

confidence: 99%

Effects of a Moderate Physical Training on the Leptin Synthesis by Adipose Tissue of Adult Rats Submitted to a Perinatal Low-protein Diet

et al. 2012

View full text Add to dashboard Cite

The aim of the study was to verify if moderate physical training affects leptin content in visceral and subcutaneous adipose tissue of adult rats subjected to a low-protein diet during the perinatal period. Male Wistar rats were divided into 2 groups according to their mother's diet during gestation and lactation: control (17% casein, C, n=12) and low-protein (8% casein, LP, n=12). On postnatal day 60, half of each group was submitted to moderate physical training (8 wks, 5 d · wk - 1, 60 min · d - 1, at 70% of VO2max, T) or not. After the physical training period, visceral and subcutaneous adipose tissues were removed. Leptin content was evaluated by western blotting. Starting from the fifth week on, T pups showed a reduction in the body weight. Similarly, LP+T offspring showed a lower body weight starting from the sixth week on. Western blotting analysis showed that leptin content in the visceral tissue was higher in the LP rats (p<0.01) and it was reversed in LP+T. No difference was found in the subcutaneous tissue. Moderate physical training attenuated the effects of a perinatal low-protein diet on the leptin content in visceral adipose tissue in adult offspring.

show abstract

“…The body lengths of pups were recorded on days 21-63 of life by measuring the external surfaces (nose-to-anus length) using a digital caliper (0.01 mm accuracy). Body weight and body length were used to determine the body mass index (BMI, g/length 2 ) [17] .…”

Section: Offspring Body Weight and Body Lengthmentioning

confidence: 99%

Moderate Physical Training Attenuates the Effects of Perinatal Undernutrition on the Morphometry of the Splenic Lymphoid Follicles in Endotoxemic Adult Rats

Moita

Lustosa²,

Silva³

et al. 2010

Neuroimmunomodulation

Self Cite

View full text Add to dashboard Cite

Background/Aims: Physical training is a well-known inducer of positive physiological adaptations. The effects of moderate physical training on the morphometry of splenic lymphoid follicles of endotoxemic rats submitted to a perinatal low-protein (LP) diet were evaluated. Methods: Male Wistar rats were divided into two groups according to their mother’s diet (17% casein, control, C) and, undernourished (8% casein, LP diet). On postnatal day 63, the animals were submitted to moderate physical training (8 weeks, 5 days·week^–1, 60 min·day^–1, at 70% of VO_2max). After the physical training period, half of each group received an injection of either lipopolysaccharide (LPS) or saline. Plasma corticosterone concentration, blood differential leukocyte counts and splenic morphometric parameters were analyzed. Results: In undernourished toxemic (LP + LPS), LPS increased plasma corticosterone concentrations, but not in previously trained (LP + T + LPS) animals. Neutrophilia and lymphopenia in response to LPS was more pronounced in pups from undernourished mothers (LP + LPS). LP + LPS animals showed a higher increment (47.4%) in the number of lymphoid follicles, a reduction in the number and size of the splenic follicles, and in the marginal zone area. Those alterations were attenuated in trained animals (LP + T + LPS). Conclusions: Physical training attenuates the effects of nutritional programming on the splenic microanatomy by a mechanism that involves the hypothalamic-pituitary-adrenal axis.

show abstract

Short- and long-term effects of a neonatal low-protein diet in rats on the morphology of the larynx

Cited by 9 publications

References 23 publications

Effects of high-fat diet on somatic growth, metabolic parameters and function of peritoneal macrophages of young rats submitted to a maternal low-protein diet

Effects of high-fat diet on somatic growth, metabolic parameters and function of peritoneal macrophages of young rats submitted to a maternal low-protein diet

Effects of a Moderate Physical Training on the Leptin Synthesis by Adipose Tissue of Adult Rats Submitted to a Perinatal Low-protein Diet

Moderate Physical Training Attenuates the Effects of Perinatal Undernutrition on the Morphometry of the Splenic Lymphoid Follicles in Endotoxemic Adult Rats

Contact Info

Product

Resources

About