Short- and long-term follow-up of living kidney donors

Abdellaoui, Imen; Azzabi, A.; Sahtout, W.; Sabri, F.; Hmida, Wissem; Achour, A.

doi:10.4103/1319-2442.256848

Cited by 8 publications

(5 citation statements)

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“…In the present study, serum creatinine levels significantly increased compared to the pre-donation. The results were consistent with results of some previous studies, but they did not increase significantly in some studies (11,(13)(14)(15). The kidneys play important roles in the blood sugar homeostasis.…”

Section: Discussionsupporting

confidence: 92%

Study of the kidney function remaining in kidney donors and its related factors in transplant center of Imam Khomeini hospital, Urmia

et al. 2020

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Introduction: Concerns about the occurrence of premature kidney failure have been expressed a few years after the kidney donation in the donor due to increase in compensatory blood flow in the remaining kidney nephrons. Objectives: This study aimed to study the kidney function remaining in living kidney donors and its related factors. Patients and Methods: Data were collected from 30 kidney donors in Imam Khomeini hospital in Urmia and evaluated using SPSS-22 software. Results: The mean duration of nephrectomy was 36.36 ± 6.22 years. The mean serum creatinine was significantly increased at the time of examination than before donation, and the glomerular filtration rate (GFR) decreased significantly (P<0.001). Male donors (P=0.025) and donors who did not have relative relationship with the recipient (P=0.44) had better kidney function. The renal function at the time of examination was 74.86% amount before donation. The glucose tolerance test (mg/dL 2 hours) of the donors increased significantly at the time of the study compared to the time before donation (P=0.049). Conclusion: The remaining kidney function of the donors has decreased significantly seven years after donation. It seems that kidney donors need more time to excrete excess glucose, so they are far from being over-carbohydrate.

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Section: Discussionsupporting

confidence: 92%

Study of the kidney function remaining in kidney donors and its related factors in transplant center of Imam Khomeini hospital, Urmia

et al. 2020

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“…The quantification of the GFR <60 mL/min/1.73m 2 has important implications for the definition of CKD in renal donors over time (49). In our study, we found a significant decrease in GFR at 6 months of follow-up, which suggests that renal donors are approximately in stage 2 of CKD (50).…”

Section: Discussionmentioning

confidence: 51%

The Alteration of Pro-inflammatory Cytokines and Oxidative Stress Markers at Six-Month Post-living Kidney Donation

et al. 2020

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Donors have a higher risk of developing chronic kidney disease than the general population. Some mechanisms mediated by pro-inflammatory cytokines and oxidative stress may be involved as risk factors. The objective of the study was to evaluate the behavior of pro-inflammatory cytokines and oxidative stress markers in living renal donors with a 6-month follow-up. A single prospective cohort was performed in 88 renal donors. At the end of the follow-up, the levels of lipoperoxides, 6.52 ± 1.12 mM, and 8-isoprostanes, 63.75 ± 13.28 pg/mL, were lower than before donation, 10.20 ± 3.95 mM (p < 0.001) and 67.54 ± 9.64 pg/mL (p = 0.026), respectively. Initial levels of nitric oxide (NO), 356.09 ± 59.38 µM increased at the end of the follow-up, 467.08 ± 38.74 µM (p < 0.001). It was observed in the final determination of donors decreased activity of antioxidant enzymes superoxide dismutase (SOD), 0.74 ± 0.57 U/L and glutathione peroxidase (GPx), 556.41 ± 80.37 nmol, in comparison with the levels obtained in the initial determination, 1.05 ± 0.57 U/L (p < 0.001) and 827.93 ± 162.78 nmol (p < 0.001), respectively. The pro-inflammatory cytokines, Tumor necrosis factor alpha and interleukin-6 showed no differences at 6 months after donation. The enzyme oxoguanine glycosylase (hOGG1) responsible for repairing oxidative damage to DNA, showed a decrease in its concentration at the end of the study in donor men, 0.40 ± 0.21 ng/mL compared to the initial levels, 0.55 ± 0.32 ng/mL (p = 0.025). The marker, 8-hydroxy-2-deoxyguanosine (8-OHdG) exhibited an increase in donor men at the final determination 2.28 ± 1.99 ng/mL, compared to the concentration before donation, 1.72 ± 1.96 ng/mL (p < 0.001). We found significant changes in the markers of the oxidative state with increased NO and 8-OHdG, as well as a significant decrease in the antioxidant defenses SOD, GPx, and in the DNA repair enzyme in living renal donors after 6 months of follow-up.

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“…We reflected the experience gained in open surgery on LLDN and realized that it eases the procedure of kidney donation. Our donor’s mean BMI was higher than many studies in the literature [14-18]. The rate was 29.3%, and nearly 1 of 3 donors was obese.…”

Section: Discussionmentioning

confidence: 52%

Laparoscopic Live Donor Nephrectomy: Experience of High-Volume Center with 2,477 Cases

et al. 2020

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Objective: Donors’ health and safety are mandatory in the living-donor kidney transplantation procedure. Laparoscopic live donor nephrectomy (LLDN) provides an increase in donor numbers with its benefits and becomes a standard of care. We aimed to explain the results, complication rates, tips, and tricks of the largest number of LLDN case series ever performed in the literature. Materials and Methods: Between August 2012 and December 2019, 2,477 live donor case files were analyzed retrospectively. Age, gender, hospitalization times, body mass index, warm ischemia times, operation times, numbers of arteries, side of the kidneys, and complications were noted. Results: 1,421 (57.4%) of 2,477 donors were female (p = 0.007). Operation times and warm ischemia times were found longer in right-sided LLDN and donors with multiple renal arteries (p = 0.046, <0.001, and <0.001, respectively). Obesity (BMI >30 kg/m2) did not affect warm ischemia times while prolonging the operation times (p = 0.013). Hospitalization times and numbers of complications were higher in obese donors. Conclusions: LLDN seems to be a reliable solution with fewer complications and higher satisfaction rates. We hope to illuminate the way with tips and trick points for beginner transplant surgeons based on the experience obtained from 2,477 LLDN cases.

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Short- and long-term follow-up of living kidney donors

Cited by 8 publications

References 1 publication

Study of the kidney function remaining in kidney donors and its related factors in transplant center of Imam Khomeini hospital, Urmia

Study of the kidney function remaining in kidney donors and its related factors in transplant center of Imam Khomeini hospital, Urmia

The Alteration of Pro-inflammatory Cytokines and Oxidative Stress Markers at Six-Month Post-living Kidney Donation

Laparoscopic Live Donor Nephrectomy: Experience of High-Volume Center with 2,477 Cases

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