<b><i>Objective:</i></b> Donors’ health and safety are mandatory in the living-donor kidney transplantation procedure. Laparoscopic live donor nephrectomy (LLDN) provides an increase in donor numbers with its benefits and becomes a standard of care. We aimed to explain the results, complication rates, tips, and tricks of the largest number of LLDN case series ever performed in the literature. <b><i>Materials and Methods:</i></b> Between August 2012 and December 2019, 2,477 live donor case files were analyzed retrospectively. Age, gender, hospitalization times, body mass index, warm ischemia times, operation times, numbers of arteries, side of the kidneys, and complications were noted. <b><i>Results:</i></b> 1,421 (57.4%) of 2,477 donors were female (<i>p</i> = 0.007). Operation times and warm ischemia times were found longer in right-sided LLDN and donors with multiple renal arteries (<i>p</i> = 0.046, &#x3c;0.001, and &#x3c;0.001, respectively). Obesity (BMI &#x3e;30 kg/m²) did not affect warm ischemia times while prolonging the operation times (<i>p</i> = 0.013). Hospitalization times and numbers of complications were higher in obese donors. <b><i>Conclusions:</i></b> LLDN seems to be a reliable solution with fewer complications and higher satisfaction rates. We hope to illuminate the way with tips and trick points for beginner transplant surgeons based on the experience obtained from 2,477 LLDN cases.

Our objective in this experimental study is to research the effect of the intra-abdominal pressure which rises following pneumoperitoneum and whether Theophylline has a possible protective activity on this situation. In our study, 24 Wistar Albino rats were used. Rats were divided into two groups. The first group was set for only pneumoperitoneum model. The second group was given 15 mg/kg of Theophylline intraperitoneally before setting pneumoperitoneum model. Then urea, creatinine, cystatin-C, tissue and serum total antioxidant capacity, total oxidant capacity and oxidative stress index in two groups were measured and compared with each other. Apoptosis and histopathological conditions in the renal tissues were examined. The differences between the groups were analyzed with the Mann-Whitney U test. Results were considered significant at p50.05. No statistically significant difference was determined between tissue and serum averages in two groups in terms of TAS, TOS and OSI values (p40.05). The mean value of urea were similar in pneumoperitoneum and pneumoperitoneum + theophylline groups (p ¼ 0.12). The mean cystatin-C value was 2.2 ± 0.3 mg/mL in pneumoperitoneum, 1.74 ± 0.33 mg/mL in pneumoperitoneum + theophylline (p ¼ 0.002). According to our study, lower cystatin-C levels in the group, where Theophylline was given, are suggestive of lower renal injury in this group. However, this opinion is interrogated as there is no difference in terms of tissue and serum TAS, TOS, OSI and urea values between the groups.

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Objectives: In this study, we aimed to investigate whether Ga-68 prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA PET/CT) scanning is adequate to predict intermediate risk, high risk, or oligometastatic prostate cancer (PCa) as an initial staging modality. Methods: The Ga-68 PSMA PET/CT scan images of 50 PCa patients pathologically proven by transrectal ultrasound guided biopsy were evaluated retrospectively. The association of standard uptake value maximum (SUV max ) value of the area with the highest PSMA expression within the primary tumor with the risk groups and metastatic burden is investigated. Results: The SUV max value was 6.18 in oligometastatic patients where it was measured as 10.93 in patients with higher metastatic burden (p=0.037). The cut-off SUV max value for multiple metastases was 7.96 (p=0.047). According to the regression model, SUV max value has a positive influence [odds ratio (OR)=1.42], which was statistically significant (p=0.038). SUV max values for intermediate and high risk patients were 6.91 and 11.44, respectively (p=0.014). The cut-off SUV max value for the high risk group was 10.55 (p=0.006). In the regression model, SUV max value has a positive influence (OR=1.198), which was statistically significant (p=0.021). Conclusion: In this paper, we demonstrated the association between SUV max value of primary tumor and Gleason score. Our results also allowed us to suggest that primary tumor SUV max is a sufficiently accurate predictor of D’Amico risk groups in newly diagnosed PCa cases. Additionally, Ga-68 PSMA PET/CT turns out to be a useful tool in determining oligometastatic PCa, which requires a different treatment approach.

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