Short communication: Associations between blood fatty acids, β-hydroxybutyrate, and α-tocopherol in the periparturient period in dairy cows: An observational study

Pilotto, A.; Savoini, G.; Baldi, Alfonso; Invernizzi, G.; Vecchi, Chiara; Θεοδώρου, Γεώργιος; Koutsouli, Panagiota; Politis, I.

doi:10.3168/jds.2016-10938

Cited by 8 publications

(12 citation statements)

References 27 publications

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“…Fatty acids (FFA) and b-hydroxybutyrate (BHB) are the two markers used to assess the severity of the negative energy balance. In a previous study including four commercial farms located in Italy and Greece, our group showed that these two markers are not well correlated during the transition period (Pilotto et al 2016). In fact, the concentration of free fatty acids in blood became maximal during calving and declined postpartum, while BHB continued to increase in the postpartum period.…”

Section: Introductionmentioning

confidence: 77%

“…Diets on all farms have been reported in detail in a previous study from our group (Pilotto et al 2016).…”

Section: Methodsmentioning

confidence: 99%

“…The amounts of FFA, BHB and a-T were determined, and the results were described in detail in a previous paper published by our group. Furthermore, information concerning milk production and milk composition can be found in the same paper (Pilotto et al 2016).…”

Section: Methodsmentioning

confidence: 99%

“…The fact that we have already determined FFA and BHB values in blood samples from four commercial farms (Pilotto et al 2016) gave us the incentive to extend our previous investigation and to use the index proposed by Abuelo et al (2013) on a larger scale, determining ROS, SAC and OSi. Our working hypothesis is that a positive association occurs between markers of oxidative stress and metabolic indices in dairy cows.…”

Section: Introductionmentioning

confidence: 99%

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Oxidative indices as metabolic stress predictors in periparturient dairy cows

Invernizzi

Koutsouli

Savoini

et al. 2019

Italian Journal of Animal Science

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The aim of the study was to determine changes in reactive oxygen species (ROS), serum antioxidant capacity (SAC) and oxidative stress index (OSi; ROS/SAC) from dry off to 30 days postpartum in dairy cows. Furthermore, the relationship between indices of oxidative status (ROS, SAC, OSi) and indices related to metabolic disorders (blood free fatty acids, FFA and b-hydroxybutyrate, BHB) and a-tocopherol (a-T) was determined. Blood samples were collected from 131 dairy cows belonging to four commercial farms, located in Italy and Greece. Blood samples were collected at dry-off, calving and 30 days postpartum. Results indicated that ROS and OSi were low at dry-off and 30 days postpartum and high at calving. The serum antioxidant capacity followed exactly the opposite trend. There was a negative correlation of ROS (rho: À0.282; p .01) and OSi (rho: À0.267; p .05) with aT at all three sampling points, whereas no correlation was found between SAC and aT. Reactive oxygen species were positively correlated with BHB at all three sampling points and with FFA levels only at dry-off. A negative correlation of SAC with FFA was found at dry-off and 30 days postpartum. The oxidative stress index was positively correlated with FFA and BHB at dry-off, with FFA at calving and with BHB at 30 days postpartum. Thus, associations between parameters related to oxidative status and those related to energy balance were found, mainly at dry-off and postpartum. Oxidative stress markers determined at dry off could be useful in preventing metabolic disorders. HIGHLIGHTS Dairy cows around calving often incur metabolic disorders. Associations between oxidative and metabolic markers were found mainly at dry-off and postpartum. Oxidative markers could be used as a tool for metabolic disorders prevention.

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Section: Introductionmentioning

confidence: 77%

“…Diets on all farms have been reported in detail in a previous study from our group (Pilotto et al 2016).…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Oxidative indices as metabolic stress predictors in periparturient dairy cows

Invernizzi

Koutsouli

Savoini

et al. 2019

Italian Journal of Animal Science

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“…Supplementing dairy cattle with adequate amounts of vitamin E and Se is thus now a widely-accepted practice. However, adequate levels of these micronutrients do not completely control oxidative stress around calving (3,6,27). Numerous studies in dairy cows (34) have shown that the plasma vitamin E concentration decreases gradually around parturition, reaching the lowest values around calving and then increasing gradually afterwards.…”

Section: Vitamin Ementioning

confidence: 99%

The role of micronutrients in high-yielding dairy ruminants: Choline and vitamin E

Pinotti

Manoni

Fumagalli

et al. 2020

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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This review addresses the potential role of antioxidants and methyl-group sources in optimising the metabolic health of dairy ruminants. The productivity of high-yielding dairy cows has increased over the past 40 years and the milk yield has doubled. Such increases in milk production have been observed not only in dairy cows but also to some extent in other dairy ruminants such as ewes, goats and buffaloes (Bubalus bubalis). As a consequence, in all specialized dairy ruminants it is essential to optimize the macro and micro-nutrient supply, especially during the most critical period in the animals' production cycle i.e. from parturition until the peak of lactation. In this critical phase, an array of factors can enhance the balance between the intake and demand for nutrients, although the availability and supply of the selected micronutrients is also important. The supplementation of dietary antioxidants or boosting the endogenous methyl group status, via vitamin E, selenium and choline are proposed as possible strategies in maintaining stable metabolic health and optimising milk production.

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Tresholds of blood variables obtained by receiver operating characteristic analysis for indication of fat and glycogen content in the liver of postpartum dairy cows

Podpečan

Zrimšek

Mrkun

et al. 2020

Italian Journal of Animal Science

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The objective was to determine optimal thresholds of blood variables that are associated with liver lipid and glycogen content in dairy cows. Liver specimens of 15 Holstein dairy cows were taken 2 weeks postpartum (PP) and used for determination of lipid and glycogen content, respectively. Blood samples were collected weekly, starting from week 2 antepartum (AP) up to week 2 PP. Selected blood parameters and body condition scoring (BCS) were evaluated through receiver operating characteristic curve analysis as indication of fat and glycogen content in the liver. Postpartal low liver glycogen content (mode < 2.0, semiquantitative analysis of glycogen content in the liver tissue samples) can be indicated if values are higher than 0.16 mmol/L, and 3.5 mmol/L for NEFA, and glucose, respectively, and lower than 0.65 mmol/L and 17.94 lU/mL for BHBA and insulin, respectively, 2 weeks AP. Postaprtal high liver fat content (>20%, stereological quantification of fat content in the liver tissue samples) can be indicated if values are higher than 3.5 for BCS at week 2 AP. Optimal time for indicating both low liver glycogen/high fat content is 1 week PP, with LDL < cut off point set at 0.18 mmol/L and BHBA > cut off point set at 0.88 mmol/L. Established cut off values in this study can be used for indication of fat and glycogen content in the liver of dairy cows. HIGHLIGHTSMore variables are reliable for indication of liver glycogen content than for indication of liver fat content. Postpartum concentrations of LDL and BHBA can be used for indicating both high lipid liver content and low liver glycogen content.

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Short communication: Associations between blood fatty acids, β-hydroxybutyrate, and α-tocopherol in the periparturient period in dairy cows: An observational study

Cited by 8 publications

References 27 publications

Oxidative indices as metabolic stress predictors in periparturient dairy cows

Oxidative indices as metabolic stress predictors in periparturient dairy cows

The role of micronutrients in high-yielding dairy ruminants: Choline and vitamin E

Tresholds of blood variables obtained by receiver operating characteristic analysis for indication of fat and glycogen content in the liver of postpartum dairy cows

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