Short incubation with methyl aminolevulinate for photodynamic therapy of actinic keratoses

Lr, Braathen; Be, Paredes; Saksela, Olli; Fritsch, Clemens; Gardlo, K.; Morken, Tore; Kw, Frølich; Warloe, Trond; Am, Soler; Am, Ros

doi:10.1111/j.1468-3083.2008.03029.x

Cited by 59 publications

(57 citation statements)

References 15 publications

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“…Despite this pretreatment, thicker AKs respond at a reduced rate and may require more treatment sessions to achieve clearance. 22,61,39 PDT does not effect a full reversal of photodamage in all instances; AKs may begin to emerge after 4 to 6 months. 18,62 In patients with a history of NMSC, 2 sessions of ALA-PDT delayed the emergence of AKs and other lesions from severely photodamaged skin, relative to placebo treatment.…”

Section: Pdt and Daylight Pdtmentioning

confidence: 99%

Non-melanoma Skin Cancer in Canada Chapter 3: Management of Actinic Keratoses

et al. 2015

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Background Actinic keratosis (AK) and cheilitis (AC) are lesions that develop on photodamaged skin and may progress to form invasive squamous cell carcinomas (SCCs). Objective To provide guidance to Canadian health care practitioners regarding management of AKs and ACs. Methods Literature searches and development of graded recommendations were carried out as discussed in the accompanying introduction (chapter 1 of the NMSC guidelines). Results Treatment of AKs allows for secondary prevention of skin cancer in sun-damaged skin. Because it is impossible to predict whether a given AK will regress, persist, or progress, AKs should ideally be treated. This chapter discusses options for the management of AKs and ACs. Conclusions Treatment options include surgical removal, topical treatment, and photodynamic therapy. Combined modalities may be used in case of inadequate response. AKs are particularly common following the longterm immunosuppression in organ transplant patients, who should be monitored frequently to identify emerging lesions that require surgery.

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Section: Pdt and Daylight Pdtmentioning

confidence: 99%

Non-melanoma Skin Cancer in Canada Chapter 3: Management of Actinic Keratoses

et al. 2015

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“…The most recent studies include use of keratolytics, curettage/ debulking, tape stripping, microdermabrasion, and laser ablation. 21,45,46 One split-face study demonstrated slightly superior efficacy and long-term improvement of actinic keratoses when using microneedling as a delivery system. 47 Use of microneedling in SCC in situ and BCC failed to demonstrate either increased fluorescence uptake or clinical superiority.…”

Section: Light Source and Methods Of Deliverymentioning

confidence: 99%

Current Evidence and Applications of Photodynamic Therapy in Dermatology

2015

Journal of the Dermatology Nurses' Association

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Abstract:In photodynamic therapy (PDT) a photosensitizer -a molecule that is activated by light -is administered and exposed to a light source. This leads both to destruction of cells targeted by the particular type of photosensitizer, and immunomodulation. Given the ease with which photosensitizers and light can be delivered to the skin, it should come as no surprise that PDT is an increasingly utilized therapeutic in dermatology. PDT is used commonly to treat precancerous cells, sun-damaged skin, and acne. It has reportedly also been used to treat other conditions including inflammatory disorders and cutaneous infections. This review discusses the principles behind how PDT is used in dermatology, as well as evidence for current applications of PDT.

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“…A resposta clínica das QAs com TFD está bem estabelecida na literatura 9,[83][84][85] . Existem, certamente, diferenças nos diversos protocolos em relação ao tipo de droga usada, tempo de incubação, veículo, fonte de luz, dose e irradiância da fonte de luz, preparo ou não das lesões, etc.…”

Section: He 200xunclassified

“…Cabe ressaltar que, o preparo prévio das lesões, ou seja, uma leve curetagem sem sangramento, suficiente para a remoção das crostas e/ou hiperqueratose e a aplicação correta da droga sobre as mesmas são de extrema importância para o índice de cura das QAs. Da mesma forma, chamamos a atenção para o tempo de incubação assim como a dose de luz corretamente aplicadas 9,48,49,53,54,60,61,66,67,69,[83][84][85] . No estudo que mais se assemelha ao nosso protocolo, Zane et al 62 observaram resposta completa de 71,5% após a primeira sessão e de 88,3% após duas sessões.…”

Section: He 200xunclassified

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Estudo da pele do campo cancerizável antes e após a terapia fotodinâmica através dos métodos clínicos, histopatológicos e imunohistoquímicos

Torezan¹

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Short incubation with methyl aminolevulinate for photodynamic therapy of actinic keratoses

Abstract: MAL-PDT using a 1-h incubation may be sufficient for successful treatment of selected AK lesions.

Cited by 59 publications

References 15 publications

Non-melanoma Skin Cancer in Canada Chapter 3: Management of Actinic Keratoses

Non-melanoma Skin Cancer in Canada Chapter 3: Management of Actinic Keratoses

Current Evidence and Applications of Photodynamic Therapy in Dermatology

Estudo da pele do campo cancerizável antes e após a terapia fotodinâmica através dos métodos clínicos, histopatológicos e imunohistoquímicos

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