Short-term effects of fine particulate matter on acute myocardial infraction mortality and years of life lost: A time series study in Hong Kong

Liang, Haiqing; Qiu, Hong; Tian, Linwei

doi:10.1016/j.scitotenv.2017.09.266

Cited by 53 publications

(21 citation statements)

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“…We studied the elderly and the elderly make up a high-risk group[22,23]. The short-term association of PM 2.5 with mortality from circulatory diseases was consistent with previous epidemiological studies[17]. PM 2.5 may reduce cardiac parasympathetic input leading to decreased heart rate variability (HRV)[24,25].…”

Section: Discussionmentioning

confidence: 55%

“…No study on the relationship between short-term exposure to PM 2.5 and mortality risk has been conducted in Changchun. Since the elderly are more vulnerable to air pollution[17,18], we therefore conducted a time-series study of the elderly in Changchun to evaluate the short-term effect of PM 2.5 on non-accidental and circulatory disease mortality, and explored the potential effect modification by sex, education and death location.…”

Section: Introductionmentioning

confidence: 99%

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Short-term effects of fine particulate matter on non-accidental and circulatory diseases mortality: A time series study among the elder in Changchun

Pan

Niu

et al. 2018

PLoS ONE

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Background and objectivesFine particulate matter (PM2.5, particulate matter with an aerodynamic diameter less than or equal to 2.5 μm) has multiple adverse effects on human health, especially on the respiratory and circulatory system. The purpose of this study was to evaluate the short-term effect of PM2.5 on the mortality risk of non-accidental and circulatory diseases, and to explore the potential effect modification by sex, education and death location.MethodsWe collected daily mortality counts of Changchun (China) residents, daily meteorology and air pollution data, from January 1, 2014, to January 1, 2017. We focused on the elderly (≥65 years old) population who died from non-accidental causes and circulatory diseases, and stratified them by sex, education, and death location. A generalized additive Poisson regression model (GAM) was used to analyse the impact of air pollutants on mortality. We fit single pollutant models to examine PM2.5 effects with different lag structures of single-day (distributed lag:lag0-lag3) and multi-day (moving average lag: lag01-lag03). To test the sensitivity of the model, a multi-pollutant model was established when the PM2.5 effect was strongest.ResultsIn the single pollutant models, an increment of PM2.5 by 10 μg/m3 at lag0-3 was associated with a 0.385% (95% CI: 0.069% to 0.702%) increase in daily non-accidental mortality and a 0.442% (95% CI: 0.038% to 0.848%) increase in daily circulatory disease mortality. NO2 (lag1) and O3 (lag0, lag1, lag2, lag01,lag02, lag03) were associated with daily non-accidental death and NO2 (lag1, lag3, lag03) and O3 (lag0, lag1, lag01,lag02, lag03) were associated with daily circulatory disease mortality. In the co-pollutant models, the risk estimates for PM2.5 changed slightly. The excess mortality risk of non-accidental and circulatory diseases was higher for women, people with low education, and died outside hospital.ConclusionsWe found that short-term exposure to PM2.5 increased the mortality risk of non-accidental and circulatory diseases among the elderly in Changchun. Women, people with low education and died outside hospital are more susceptible to PM2.5. NO2 and O3 were also associated with an increase in mortality from non-accidental and circulatory diseases and the O3 is a high effect.

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Section: Discussionmentioning

confidence: 55%

Section: Introductionmentioning

confidence: 99%

Short-term effects of fine particulate matter on non-accidental and circulatory diseases mortality: A time series study among the elder in Changchun

Pan

Niu

et al. 2018

PLoS ONE

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“…Several reviews of the adverse health effects of air pollution in the Chinese population yield similar results (Lu et al 2015 ; Shang et al 2013 ). In China, the short-term effect of the air pollution on the health burden has been studied in several cities such as Beijing, Shanghai, Wuhan, and Shenzhen (Lai and Brimblecombe 2017 ; Li et al 2015 ; Liang et al 2017 ; Lin et al 2017 ; Zhang et al 2017 ). A systematic review of 33 time series and case-crossover studies provided additional insights into the heterogeneity in effects on daily mortality after exposure to air pollution in China (Shang et al 2013 ).…”

Section: Introductionmentioning

confidence: 99%

Temporal trends in respiratory mortality and short-term effects of air pollutants in Shenyang, China

Xue

Chen

Sun

et al. 2018

Environ Sci Pollut Res

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Short-term exposures to air pollution are associated with acute effects on respiratory health. This study aimed to describe 10-year temporal trends in respiratory mortality in the urban areas of Shenyang, China, according to gender and age and estimate the effects of air pollution on respiratory diseases (ICD-10J00-J99) and lung cancer (ICD-10 C33-C34) using a case-crossover design. During the study period 2013–2015, the exposure-response relationship between ambient air pollutants and mortality data was fitted by a quasi-Poisson model. Age-standardized mortality rates for a combined number of respiratory diseases and for lung cancer declined in Shenyang; however, death counts increased with aging. Deaths from respiratory diseases increased by 4.7% (95% CI, 0.00–9.9), and lung cancer mortality increased by 6.5% (95% CI, 1.2–12.0), both associated with a 10 μg/m3 increase in exposure to particulate matter < 2.5 μg in diameter (PM2.5). Moreover, males in Shenyang’s urban areas were more susceptible to the acute effects of PM2.5 and SO2 exposure; people aged ≥ 65 years had a high susceptibility to ozone, and those aged < 65 years were more susceptible to other air pollutants. These results provided an updated estimate of the short-term effects of air pollution in Shenyang. Since population aging is also associated with increasing mortality from respiratory diseases and lung cancer, reinforcing air quality control measures and health-promoting behaviors is urgent and necessary in Shenyang.Electronic supplementary materialThe online version of this article (10.1007/s11356-018-1270-5) contains supplementary material, which is available to authorized users.

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“…About 80% of those deaths are due to heart diseases and stroke 1 . Epidemiological and experimental studies have also demonstrated the causal relationship between acute PM 2.5 exposure and elevated morbidity and mortality of cardiovascular diseases 2–5 . Many researches have been done targeting the association between PM 2.5 and cardiovascular diseases, however, the underlying mechanism is still poorly understood.…”

Section: Introductionmentioning

confidence: 99%

The harmful effects of acute PM2.5 exposure to the heart and a novel preventive and therapeutic function of CEOs

Dong

Sun

et al. 2019

Sci Rep

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Epidemiological researches have demonstrated the relationship between PM 2.5 exposure and increased morbidity and mortality of cardiovascular injury. However, no effective therapeutic method was established. The purpose of this study is to investigate the effect of acute PM 2.5 exposure on the mice heart tissue and explore the therapeutic effects of compound essential oils (CEOs) in this model. In this study, after mice were exposed to PM 2.5 intratracheally, some obvious histopathological changes as well as some great alterations of proinflammatory cytokines were observed in the heart tissue. The imbalance of oxidative stress, the altered Ca 2+ channel related proteins and the increased intracellular free Ca 2+ were all involved in the heart impairment and would also be investigated in this model. The CEOs alleviated the heart impairment via its antioxidant effect rather than its anti-inflammatory function because our results revealed that oxidative stress related indicators were restored after CEOs administration. At the same time, increased concentration of intracellular free Ca 2+ and ROS induced by PM 2.5 were reduced after NAC (N-Acetyl-L-cysteine) administration. These data suggested that the acute PM 2.5 exposure would damage heart tissue by inducing the inflammatory response, oxidative stress and intracellular free Ca 2+ overload. PM 2.5 -induced oxidative stress probably increase intracellular free Ca 2+ via RYR2 and SERCA2a. CEOs have the potential to be a novel effective and convenient therapeutic method to prevent and treat the acute heart impairment induced by PM 2.5 via its antioxidant function.

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Short-term effects of fine particulate matter on acute myocardial infraction mortality and years of life lost: A time series study in Hong Kong

Cited by 53 publications

References 47 publications

Short-term effects of fine particulate matter on non-accidental and circulatory diseases mortality: A time series study among the elder in Changchun

Short-term effects of fine particulate matter on non-accidental and circulatory diseases mortality: A time series study among the elder in Changchun

Temporal trends in respiratory mortality and short-term effects of air pollutants in Shenyang, China

The harmful effects of acute PM2.5 exposure to the heart and a novel preventive and therapeutic function of CEOs

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