Short term exposure to 1439 MHz pulsed TDMA field does not alter melatonin synthesis in rats

Hata, Keisuke; Yamaguchi, Hironori; Tsurita, Giichiro; Watanabe, Soichi; Wake, Kanako; Taki, Masao; Ueno, S.; Nagawa, Hirokazu

doi:10.1002/bem.20080

Cited by 23 publications

(16 citation statements)

References 21 publications

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“…The widespread use of the mobile phone has initiated many studies on the possible adverse effects of a high frequency EMF, emitted from mobile phones (Hata et al, 2005). As a tax of civilian life, electromagnetic field may induce biochemical and pathological alterations to the cell membrane, various enzymatic systems and electrolytic balanced components.…”

Section: Discussionmentioning

confidence: 99%

Glutathione Enhancer Protects Some Biochemical and Haematological Parameters from the Effect of Electromagnetic Field

2016

Egypt. J. Rad.Sci.

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HE PRESENT study was designed to study the effect of exposure to electromagnetic field (EMF), emitted from a cellular tower for mobile phone on some biochemical and haematological parameters in male albino rats and to evaluate of the possible protective role of the antioxidant glutathione enhancer on the studied parameters.Three groups of rats were studied, the control (unexposed), the exposed and the treated exposed groups. Exposed groups were subjected to EMF at frequency of 900MHz, with a peak power of about 60W, power density of 0.05mW/ cm 2 at the site of exposure for 24h/ day for 8weeks, at the same time treated group was supplied with oral injection of glutathione enhancer three times weekly.At the end of experiment, serum levels of thyroid stimulating hormone (TSH), calcium (Ca), uric acid, malondialdehyde (MDA) beside, the activity of lactate dehydrogenase (LDH) were measured also, some haematological parameters were estimated. Impairment of TSH and serum calcium was expressed by a decrease in serum levels of the exposed group. Meanwhile, serum level of MDA, uric acid and the activity of LDH were increased by exposure.The haematological studies revealed that, exposure to electromagnetic spectrum induced significant reduction in red blood cell counts (RBC's), and haemoglobin concentration (Hb), meanwhile reticulocyte count (Ret) was elevated.The leucocyte counts (WBC's) and platelets count were not affected by exposure.The study demonstrated that glutathione enhancer can attenuate the side effects of exposure to electromagnetic field.

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Section: Discussionmentioning

confidence: 99%

Glutathione Enhancer Protects Some Biochemical and Haematological Parameters from the Effect of Electromagnetic Field

2016

Egypt. J. Rad.Sci.

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“…Finnie (2005) reported there was no change in the proto-oncogene c-fos protein level in the mouse brain after a short-term exposure. Hata et al (2005), studying the secretion of melatonin and serotonin from the rat pineal gland, found no changes either. One long-term study exposed rats for 90 min per day, 5 days per week for 104 weeks; this chronic exposure did not induce tumor growth in the rat central nervous system (Shirai et al, 2005).…”

Section: Introductionmentioning

confidence: 91%

Upregulation of Specific mRNA Levels in Rat Brain After Cell Phone Exposure

Yan

Agresti

Zhang

et al. 2008

Electromagnetic Biology and Medicine

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Adult Sprague-Dawley rats were exposed to regular cell phones for 6 h per day for 126 days (18 weeks). RT-PCR was used to investigate the changes in levels of mRNA synthesis of several injury-associated proteins. Calcium ATPase, Neural Cell Adhesion Molecule, Neural Growth Factor, and Vascular Endothelial Growth Factor were evaluated. The results showed statistically significant mRNA up-regulation of these proteins in the brains of rats exposed to cell phone radiation. These results indicate that relative chronic exposure to cell phone microwave radiation may result in cumulative injuries that could eventually lead to clinically significant neurological damage.

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“…Hata et al (2005) reported that shortterm exposure to 1439-MHz pulse-modulated RF fields did not alter melatonin or serotonin synthesis in rats. Sukhotina et al (2006) noted alterations in melatonin secretion when isolated pineal glands from hamsters were exposed to 1800-MHz RF fields at SARs of 0.8 and 2.7 W/kg.…”

Section: Melatonin Levelsmentioning

confidence: 98%

Recent Advances in Research on Radiofrequency Fields and Health: 2004–2007

Habash

Elwood

Krewski

et al. 2009

Journal of Toxicology and Environmental Health, Part B

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The widespread use of wireless telecommunications devices, particularly mobile phones and wireless networks, has resulted in increased human exposure to radiofrequency (RF) fields. Although national and international agencies have established safety guidelines for exposure to RF fields, concerns remain about the potential for adverse health outcomes to occur in relation to RF field exposure. The extensive literature on RF fields and health was reviewed by a number of authorities, including the Royal Society of Canada (1999). This report is the third in a series of updates to the original report of the Royal Society of Canada, covering the period 2004-2007. In particular, the present study examined new data on (1) dosimetry and exposure assessment, (2) biological effects of RF fields such as enzyme induction, and (3) toxicological effects, including genotoxicity and carcinogenicity. Epidemiological studies of the potential health effects of RF exposure, particularly from mobile phones, were determined, along with human and animal studies of neurological and behavioural effects. Within the last 4 yrs investigators concluded that there is no clear evidence of adverse health effects associated with RF fields, although continued research is recommended to address specific areas of concern, including exposure to RF fields among children using mobile phones. The results of the ongoing 13-country World Health Organization INTERPHONE study of mobile phones may provide important new information on the potential cancer risks associated with mobile phone use.

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Short term exposure to 1439 MHz pulsed TDMA field does not alter melatonin synthesis in rats

Cited by 23 publications

References 21 publications

Glutathione Enhancer Protects Some Biochemical and Haematological Parameters from the Effect of Electromagnetic Field

Glutathione Enhancer Protects Some Biochemical and Haematological Parameters from the Effect of Electromagnetic Field

Upregulation of Specific mRNA Levels in Rat Brain After Cell Phone Exposure

Recent Advances in Research on Radiofrequency Fields and Health: 2004–2007

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