Short-term l-arginine supplementation attenuates elevation of interleukin 6 level after resistance exercise in overweight men

Nascimento, Marcos Antonio do; Lira, Fábio Santos; Punaro, Giovana Rita; Mello, Marco Túlio de; Tufik, Sérgio; Higa, Elisa Mieko Suemitsu

doi:10.1016/j.clnesp.2017.09.001

Cited by 3 publications

(17 citation statements)

References 21 publications

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“…The remaining 55 papers were designated for full-text reading. Lastly, seven studies [ 12 , 13 , 14 , 16 , 17 , 18 , 19 ] were included in the qualitative analysis (systematic review). Characteristics of studies included are provided in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

“…All studies were involved in quantitative synthesis (meta-analysis). Amongst them, four studies assessed oxidative stress [ 14 , 16 , 17 , 18 ], two analyzed antioxidants [ 14 , 19 ], and three analyzed inflammatory and anti-inflammatory markers [ 12 , 13 , 14 ]. The search process and selection step details are established in the PRISMA protocol flow diagram (see Figure 1 ).…”

Section: Resultsmentioning

confidence: 99%

“…The studies included in this review were published between 2009 and 2022 ( Table 1 ). Five studies were finalized in Brazil [ 12 , 13 , 14 , 16 , 17 ], one in Spain [ 18 ] and one in Iran [ 19 ]. Five references used RCT (crossover) study design [ 12 , 13 , 14 , 17 , 19 ] and two studies used RCT (parallel) study design [ 16 , 18 ].…”

Section: Resultsmentioning

confidence: 99%

“…Only one study performed the tests on the same day [ 18 ], and one study was performed within two days [ 17 ]. Four studies enforced seven days in their protocols [ 12 , 13 , 16 , 19 ]. One study enforced an interval between three to seven days in its protocol.…”

Section: Resultsmentioning

confidence: 99%

“…Although these substances seem safe for human consumption and rarely present adverse effects [ 7 , 8 , 9 ], they may negatively influence training adaptations [ 10 , 11 ]. L-Arginine has been studied to decrease the release of pro-inflammatory myokines produced during an exercise session [ 12 , 13 , 14 ]. Therefore, the evaluation of dietary compounds with antioxidant and anti-inflammatory properties is an interesting line of research for the development of different nutritional interventions that may help immune system responses after physical exercise.…”

Section: Introductionmentioning

confidence: 99%

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Absence of Effects of L-Arginine and L-Citrulline on Inflammatory Biomarkers and Oxidative Stress in Response to Physical Exercise: A Systematic Review with Meta-Analysis

et al. 2023

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Background: The repercussions on oxidative and inflammatory stress markers under the effects of arginine and citrulline in response to exercise are not fully reached. We completed a systematic review to investigate the effects of L-Citrulline or L-Arginine on oxidative stress and inflammatory biomarkers following exercise. EMBASE, MEDLINE (PubMed), Cochrane Library, CINAHL, LILACS, and Web of Science databases were used to record the trials. This study includes randomized controlled trials (RCTs) and non-RCTs with subjects over 18 years old. Those under the intervention protocol consumed L-Citrulline or L-Arginine, and the controls ingested placebo. We recognized 1080 studies, but only 7 were included (7 studies in meta-analysis). We observed no difference between pre- vs. post-exercise for oxidative stress (subtotal = −0.21 [CI: −0.56, 0.14], p = 0.24, and heterogeneity = 0%. In the sub-group “L-Arginine” we found a subtotal = −0.29 [−0.71, 0.12], p = 0.16, and heterogeneity = 0%. For the “L-Citrulline” subgroup we observed a subtotal = 0.00 [−0.67, 0.67], p = 1.00, and heterogeneity was not applicable. No differences were observed between groups (p = 0.47), and I² = 0%) or in antioxidant activity (subtotal = −0.28 [−1.65, 1.08], p = 0.68, and heterogeneity = 0%). In the “L-Arginine” sub-group, we found a subtotal = −3.90 [−14.18, 6.38], p = 0.46, and heterogeneity was not applicable. For the “L-Citrulline” subgroup, we reported a subtotal = −0.22 [−1.60, 1.16], p = 0.75, and heterogeneity was not applicable. No differences were observed between groups (p = 0.49), and I² = 0%), inflammatory markers (subtotal = 8.38 [−0.02, 16.78], p = 0.05, and heterogeneity = 93%. Tests for subgroup differences were not applicable, and anti-inflammatory markers (subtotal = −0.38 [−1.15, 0.39], p = 0.34 and heterogeneity = 15%; testing for subgroup differences was not applicable). In conclusion, our systematic review and meta-analysis found that L-Citrulline and L-Arginine did not influence inflammatory biomarkers and oxidative stress after exercise.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Absence of Effects of L-Arginine and L-Citrulline on Inflammatory Biomarkers and Oxidative Stress in Response to Physical Exercise: A Systematic Review with Meta-Analysis

et al. 2023

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Effect of rest period configurations on systemic inflammatory response in resistance-trained women

Luk

Jones

Vingren

2021

Journal of Sports Sciences

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Resistance training and L-arginine supplementation are determinant in genomic stability, cardiac contractility and muscle mass development in rats

et al. 2018

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L-arginine supplementation has been related to increased maximum strength and improvement of hemodynamic parameters in several diseases. The aim of our study was to evaluate the effect of L-arginine supplementation and resistance training on muscle mass, hemodynamic function and DNA damage in healthy rats subjected to a low-arginine concentration diet. Twenty three Wistar rats (290-320g) were divided into 4 groups: Sedentary (SED-Arg, n = 6), Sedentary+Arg (SED+Arg, n = 6), Resistance Training (RT-Arg, n = 5), Resistance Training+Arg (RT+Arg, n = 6). Trained animals performed resistance training protocol in a squat apparatus adapted for rats (4 sets of 10–12 repetitions, 90s of interval, 4x/week, 65–75% of One Maximum Repetition, for 8 weeks). Comet assay was performed to measure DNA damage in leukocytes. The resistance training induced higher muscle mass in trained groups. The L-arginine supplementation increased both gastrocnemius and left ventricle to body mass ratio and increased left ventricle contractility without changing hemodynamic variables. The SED+Arg group showed higher concentration of extracellular heat shock protein 72 (eHSP72) and total testosterone, as well as lower uric acid concentration in blood versus SED-Arg group. The administration of isolated L-arginine supplementation and its association with resistance training promoted less damage in leukocytes DNA. In conclusion, the L-arginine supplementation showed synergistic effect with resistance training regarding leukocyte genomic stability in a low-L-arginine diet scenario.

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Short-term l-arginine supplementation attenuates elevation of interleukin 6 level after resistance exercise in overweight men

Cited by 3 publications

References 21 publications

Absence of Effects of L-Arginine and L-Citrulline on Inflammatory Biomarkers and Oxidative Stress in Response to Physical Exercise: A Systematic Review with Meta-Analysis

Absence of Effects of L-Arginine and L-Citrulline on Inflammatory Biomarkers and Oxidative Stress in Response to Physical Exercise: A Systematic Review with Meta-Analysis

Effect of rest period configurations on systemic inflammatory response in resistance-trained women

Resistance training and L-arginine supplementation are determinant in genomic stability, cardiac contractility and muscle mass development in rats

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