Short-term metabolic changes achieved by weight loss in hypertensive patients

Cordero, Alberto; Bertomeu‐Martínez, Vicente; Mazón, Pilar; Martín-Raymondi, Diego; Palma, J. L.; Anguita, Manuel; Lekuona, Iñaki; Galve, Enrique; González-Juanatey, José Ramón

doi:10.1016/j.ijcard.2010.08.051

Cited by 6 publications

(2 citation statements)

References 34 publications

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“…Clinical guidelines provide recommendations for maintaining a normal BW for the management of HTN [ 3 , 6 ]. Numerous epidemiologic studies and interventional trials have also demonstrated the major role of weight change in determining HTN risk [ 2 , 9 – 12 ].…”

Section: Introductionmentioning

confidence: 99%

Weight changes in hypertensive patients with phlegm-dampness syndrome: an integrated proteomics and metabolomics approach

Zhang

Cheng

et al. 2021

Chin Med

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Background Hypertension (HTN) patients who have phlegm-dampness syndrome (PDS) tend to be obese and have worse outcomes. However, the association of body weight (BW) changes and mechanisms underlying the pathophysiology of HTN-PDS are not well elucidated. This study aims to identify the longitudinal observations associated with the circulating markers discriminating BW changes of individuals with HTN-PDS. Methods An integrative approach relying on metabolomics and proteomics was applied to serum samples from HTN-PDS patients in a prospective cohort to identify the plausible mechanistic pathways underpinning HTN-PDS pathophysiology. Study participants were determined to have experienced a weight change if they showed a 5%–15% increase/reduction in BW at the end of the follow-up period. The joint pathway analysis and network analysis were performed using Ingenuity Pathway Analysis (IPA®) on the serum samples obtained from the participants over the period. Results The study involved 22 HTN-PDS patients who were overweight initially and were able to lose enough weight and 24 HTN-PDS individuals who developed overweight from normal BMI during a one-year follow-up. Our analysis suggested three types of phosphatidylcholine (PC) were altered. PC (22:2(13Z,16Z)/24:1(15Z)) and LysoPC (16:1(9Z)) were decreased in Queryweight gain samples, whereas the levels of PC (14:0/16:0) were increased in weight loss samples. The metabolomic analysis suggested 24 metabolites associated with HTN-PDS. Of them, 13 were up-regulated and 11 were down-regulated. The two-dimensional difference gel electrophoresis (2D DIGE) identified 45 phosphorylated proteins got altered in the HTN-PDS patients, wherein 23 were up-regulated and 22 were down-regulated. Integrated proteomic and metabolomics analyse acknowledged biomarkers PC, Complement C3, C4a/C4b, A2M and SERPINF1 as strong predictors for BW changes in HTN-PDS patients. Conclusion The combined serum proteomic and metabolomic profiling reveals a link between BW change and the complement system activity, altered phosphatidylcholine metabolism in HTN-PDS patients. Future studies with larger cohorts are required to strengthen and validate these findings.

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Section: Introductionmentioning

confidence: 99%

Weight changes in hypertensive patients with phlegm-dampness syndrome: an integrated proteomics and metabolomics approach

Zhang

Cheng

et al. 2021

Chin Med

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“…The fact that any alteration in weight could significantly affect metabolic indicators, such as FBS, blood pressure, and lipid profiles (37), has been neglected in some studies. Additionally, this study used the whole plant instead of chemical extractions because the literature review revealed that different areas of S. hortensis contain variant active components possessing dissimilar activities.…”

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confidence: 99%

The Effects of Satureja hortensis L. Dried Leaves on Serum Sugar, Lipid Profiles, hs-CRP, and Blood Pressure in Metabolic Syndrome Patients: A Double-Blind Randomized Clinical Trial

Nikaein

Babajafari

Mazloomi

et al. 2016

Iran Red Crescent Med J

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Background: Metabolic syndrome, which includes multiple metabolic disorders in an individual, has a direct relationship with incidence of various heart diseases. Satureja hortensis L. has been considered to treat this syndrome because its active compounds have valuable therapeutic effects, including anti-inflammatory, antihyperglycemic, vasodilator, and antihyperlipidemic properties as well as being antioxidants and free radical scavengers.

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Metabolic syndrome is associated with increased risk of short-term post-procedural complications after carotid artery stenting

et al. 2017

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The risk factors for post-procedural events after carotid artery stenting (CAS) have not been well established. The aim of this study was to investigate the association between metabolic syndrome (MetS) and the risk of post-CAS complications. A total of 358 consecutive patients who underwent CAS were enrolled in this prospective study. Patients' demographic data, clinical characteristics, and complications after CAS within 30 days were recorded. Logistic regression analysis was performed to identify possible risk factors for post-procedural complications after CAS. The incidence of complications after CAS within 30 days was 7.0%. Logistic regression analysis identified the following as independent risk factors for 30-day transient ischemic attacks, stroke, myocardial infarction, and death after CAS: metabolic syndrome (OR = 2.31, 95% CI 1.91-3.01, P = 0.004), diabetes (OR = 2.24, 95% CI 1.74-2.76, P = 0.026), symptomatic patient (OR = 1.73, 95% CI 1.23-3.05, P = 0.011), and age (OR = 1.87, 95% CI 1.35-2.57, P = 0.042). Among the components of MetS, central obesity (OR = 2.21, 95% CI 1.24-2.63, P = 0.006), low high-density lipoprotein cholesterol (HDL-C) (OR = 1.66, 95% CI 1.34-2.27, P = 0.022), and high fasting plasma glucose (OR = 2.32, 95% CI 1.85-2.74, P = 0.003) were associated with increased risk of 30-day complications after CAS. This present study suggests that patients with metabolic syndrome have significantly increased risk of complications after CAS within 30 days. Moreover, MetS patients with central obesity, high fasting plasma glucose, or low HDL-C have significantly increased risk of complications after CAS within 30 days.

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Short-term metabolic changes achieved by weight loss in hypertensive patients

Cited by 6 publications

References 34 publications

Weight changes in hypertensive patients with phlegm-dampness syndrome: an integrated proteomics and metabolomics approach

Weight changes in hypertensive patients with phlegm-dampness syndrome: an integrated proteomics and metabolomics approach

The Effects of Satureja hortensis L. Dried Leaves on Serum Sugar, Lipid Profiles, hs-CRP, and Blood Pressure in Metabolic Syndrome Patients: A Double-Blind Randomized Clinical Trial

Metabolic syndrome is associated with increased risk of short-term post-procedural complications after carotid artery stenting

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