Shrimp Vago5 activates an innate immune defense upon bacterial infection

Boonchuen, Pakpoom; Sakhor, Hafeeza; Jaree, Phattarunda; Somboonwiwat, Kunlaya

doi:10.1016/j.fsi.2021.10.044

Cited by 10 publications

(7 citation statements)

References 41 publications

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“…Previous studies have demonstrated that an interferon (IFN)-like protein, Lv Vago5 is transcriptionally regulated by Lv IRF and it plays a key role in shrimp response following VP AHPND infection. 24 , 25 Consistent with Lv IRF expression, a remarkable upregulation of LvVago5 at the same time point following r Lv Prx4 injection was observed. These results indicate that Lv Prx4 could trigger the Toll pathway-mediated AMP production as well as the IRF-Vago pathway.…”

Section: Resultsmentioning

confidence: 64%

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Prx4 acts as DAMP in shrimp, enhancing bacterial resistance via the toll pathway and prophenoloxidase activation

Wanvimonsuk¹,

Jaree²,

Kawai³

et al. 2023

iScience

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Section: Resultsmentioning

confidence: 64%

“…Lv Vago5 itself has been demonstrated to participate in antibacterial response through regulation of the Toll/IMD pathway/ Lv PEN4, JAK/STAT pathway and prophenoloxidase-activating system. 25 NLHS and Lv Prx4 might thus trigger the synergistic impact on significant immune activation and VP AHPND resistance.…”

Section: Discussionmentioning

confidence: 99%

Prx4 acts as DAMP in shrimp, enhancing bacterial resistance via the toll pathway and prophenoloxidase activation

Wanvimonsuk¹,

Jaree²,

Kawai³

et al. 2023

iScience

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“…353 can also modulate antibacterial infection mediated by the genes of the JAK-STAT pathway as evidenced by the study on P. vannamei infected with V. parahaemolyticus. 354 Negative regulation of JAK-STAT cascade (by dephosphorylation of STAT) in P. japonicus by βarrestin-1 and TC-45 complex affecting the expression of AMPs such as ALF-1, ALF-C1, ALF-C2 and Cru-1 to 5 have also been reported…”

Section: Down Syndrome Cell Adhesion Moleculementioning

confidence: 97%

“…Involvement of JAK‐STAT cascade in the antibacterial immunity of P. japonicus has been suggested, wherein an enzyme‐type ligand peroxiredoxin 4 (Prx4) binds to Domeless, activating the phosphorylation and nuclear translocation of STAT 353 . Vago5 can also modulate antibacterial infection mediated by the genes of the JAK‐STAT pathway as evidenced by the study on P. vannamei infected with V. parahaemolyticus 354 . Negative regulation of JAK‐STAT cascade (by dephosphorylation of STAT) in P. japonicus by βarrestin‐1 and TC‐45 complex affecting the expression of AMPs such as ALF‐1, ALF‐C1, ALF‐C2 and Cru‐1 to 5 have also been reported (Figure 6c).…”

Section: Jak‐stat Signalling In Crustacean Innate Immunitymentioning

confidence: 99%

The role of pattern recognition receptors in crustacean innate immunity

Patnaik

Baliarsingh

Sarkar³

et al. 2023

Reviews in Aquaculture

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Crustacean species are among the most valued seafood with socioeconomic and ecological implications in the global fisheries sector. Microbial infections to the farming stock due to continued expansion and aquaculture puts global crustacean production at risk. Understanding and reviewing the complex innate immune system of crustaceans would be pivotal in formulating informed decisions for the control and management of epidemic diseases, thus making the global crustacean aquaculture industry sustainable. Under the purview of innate immunity in crustaceans, pattern recognition receptors (PRRs) represent the sensors capable of discriminating non‐self pathogenic modules and invoking the activation of immune responses. The immunity to infections can be manifested at cellular (via phagocytosis, apoptosis, nodulation and encapsulation) and humoral (effected by prophenoloxidase cascade, lectins, antimicrobial proteins) levels leading to the elimination of pathogens or subversion of the pathogenic implications. In this review, we discuss the participatory role of 12 types of PRRs identified from crustacean species with an exhaustive focus on structural and functional specificities in binding to pathogens and possible execution of the immune activity. Moreover, we have elaborated on the PRRs‐associated or possible signalling cascades (Toll‐NFκB, IMD‐NFκB and JAK‐STAT) in crustacean species that could bridge our understanding of the resistance or susceptibility of the host to varied pathogenic infections thus providing clues to the regulatory mechanisms involved in pathogenesis of infectious diseases and mechanisms of immunity.

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“…However, LvVago5 was also found to be involved in antibacterial defense since LvVago5 was induced in hemocytes following infection with Vibrio parahaemolyticus (Boonchuen et al, 2022). Besides the Jak/STAT pathway, LvVago5 also activated the Toll/Imd pathway (to regulate the expression of the AMP gene Penaeidin-4) and the prophenoloxidase (melanization) system.…”

Section: Svwc Proteins and Immunity In Crustaceans: A New Frontiermentioning

confidence: 99%

Single domain von Willebrand factor type C “cytokines” and the regulation of the stress/immune response in insects

Labropoulou,

Wang,

Magkrioti

et al. 2024

Arch Insect Biochem Physiol

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The single domain von Willebrand factor type C (SVWC) appears in small secreted peptides that are arthropod‐specific and are produced following environmental stress or pathogen exposure. Most research has focused on proteins with SVWC domain that are induced after virus infection and are hypothesized to function as “cytokines” to regulate the innate immune response. The expansion of SVWC genes in insect species indicates that many other functions remain to be discovered. Research in shrimp has elucidated the adaptability of Vago‐like peptides in the innate immune response against bacteria, fungi and viruses after activation by Jak‐STAT and/or Toll/Imd pathways in which they can act as pathogen‐recognition receptors or cytokine‐like signaling molecules. SVWC factors also appear in scorpion venoms and tick saliva, underlining their versatility to acquire new functions. This review discusses the discovery and function of SVWC peptides from insects to crustaceans and chelicerates and reveals the enormous gaps in knowledge that remain to be filled to understand this enigmatic group of secreted peptides.

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Shrimp Vago5 activates an innate immune defense upon bacterial infection

Cited by 10 publications

References 41 publications

Prx4 acts as DAMP in shrimp, enhancing bacterial resistance via the toll pathway and prophenoloxidase activation

Prx4 acts as DAMP in shrimp, enhancing bacterial resistance via the toll pathway and prophenoloxidase activation

The role of pattern recognition receptors in crustacean innate immunity

Single domain von Willebrand factor type C “cytokines” and the regulation of the stress/immune response in insects

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