Sialadenoma papilliferum

Rennie, James; MacDonald, D.G.; Critchlow, H.A.

doi:10.1016/s0300-9785(84)80074-5

Cited by 31 publications

(4 citation statements)

References 8 publications

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“…SP is a subtype of intraductal papilloma, a rare benign tumour commonly found in older adults with hard palate, accounting for approximately 80%. It can also occur in the parotid gland, submandibular gland, nasopharynx and esophagus [2,3,[17][18][19][20][21][22][23][24][25][26][27][28][29][30][31]. Clinically, there are generally no obvious clinical symptoms with mostly painless growth, but sometime papillary erythema or pedicled lumps, occasional ulcers [3,[32][33][34][35][36][37][38][39][40][41][42][43].…”

Section: Discussionmentioning

confidence: 99%

Sialadenoma papilliferum: clinicopathologic, Immunohistochemical, molecular analyses of new five cases and review of the literature

et al. 2021

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Background Sialadenoma papilliferum (SP) is an extremely rare benign neoplasm of salivary glands. To explore and define the clinicopathological features of SP, we retrospectively analyzed 89 cases previously reported and five new cases. Methods The clinical features, histopathology, immunohistochemistry and molecular analysis of our cases were further performed and the related literatures were reviewed and analyzed. Results Combining 89 cases from the literature with our cases, the hard palate was the most common locations for SP. However, two of our cases were rarely located in the esophageal mucosa. Among all cases, the male gender was more affected, with the average age and median age of 61.8 and 62 years, respectively. Conventional histomorphologically, SP was characterized by complex papillary structures with a biphasic growth pattern of exophytic squamous component and endophytic glandular component. The glandular structures were lined by a double layer of epithelium composed of flattened or cuboidal basal cells and a cuboidal or columnar luminal cells formed papillary infoldings into the ductal lumina. Immunohistochemically, the luminal epithelial configurations showed strong expression of CK7 along the luminal cell membrane, while the basal myoepithelia displayed strong nuclear p63 expression. In both the glandular and squamous tumour components showed BRAF V600E-positive immunostaining and BRAF V600E mutation. Conclusion For the first time, we have comprehensively aggregated and analyzed 90 cases sialadenoma papilliferum from almost all previous publications, and further explored the clinicopathological features of SP; concordantly, this study demonstrated that SP shows a papillomatous growth pattern with exophytic and endophytic proliferation of ductal epithelium composed of double-layered cells harboring BRAF V600E mutation. Additionly, adequate treatment for SP is surgical excision, with a favorable prognosis in patients.

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Section: Discussionmentioning

confidence: 99%

Sialadenoma papilliferum: clinicopathologic, Immunohistochemical, molecular analyses of new five cases and review of the literature

et al. 2021

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“…In the present case, a 17-month follow-up period showed satisfactory healing and no evidence of recurrence, similar to most of the consulted cases. However, in two cases in the oral cavity, the lesion recurred: with SP at the junction of the hard and soft palate after excisional biopsy, recurrence occurred at the 36-month follow-up (23); and with SP in the mucosal surface of the cheek after excisional biopsy, recurrence occurred at the 36-month follow-up (9). One of the consulted cases included a transoral robotic surgery, introducing a new technology to remove SP lesions, which provides good hemostasis, less pain, and limited surgical morbidity (37).…”

Section: Discussionmentioning

confidence: 99%

Sialadenoma papilliferum: Bibliometric analysis

Vasconcelos¹,

Gerber²,

Saraiva³

et al. 2019

J Clin Exp Dent

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BackgroundSialadenoma papilliferum is a benign rare condition of salivary glands showing a characteristic papillary growth of the ductal epithelium that ends up being confused with more frequent lesions of the oral cavity. Objectives: To perform a bibliometric analysis of all articles about Sialadenoma papilliferum in the oral cavity and to add a singular case report of Sialadenoma in the lower lip.Material and MethodsA total of 36 publications referring to Sialadenoma papilliferum in the oral cavity from the PubMed platform was reviewed. The specific data were collected, and a bibliometric analysis was performed using Microsoft Excel. The results obtained were then compared with this new case report.ResultsThe people most affected with sialadenoma were white males at the average age of 56. The lesion was asymptomatic, usually white or red, with an average size of 1.4 cm, and the palate was by far the most affected site. The majority of the lesions were excised, and only two cases indicated recurrence.ConclusionsWith surgical removal, Sialadenoma papilliferum has a favorable prognosis and no further treatment is required. Due to few recorded cases of recurrence, a long follow-up period is recommended to ensure that the lesion does not redevelop. Key words:Sialadenoma papilliferum, salivary gland, oral cavity, bibliometric analysis.

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“…It is both an exophytic and endophytic papillary lesion histologically resembling syringocystadenoma papilliferum of sweat gland. The tumor is considered benign although rare recurrent cases have been reported [2, 3]. Three cases of malignant transformation of sialadenoma papilliferum have been described in the literature [4–6].…”

Section: Introductionmentioning

confidence: 99%

Mucoepidermoid Carcinoma Arising in a Background of Sialadenoma Papilliferum: A Case Report

Liu

Gnepp

Vries

et al. 2009

Head and Neck Pathol

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Sialadenoma papilliferum is a rare tumor, primarily of minor salivary gland origin, first described by Abrams and Finck (Cancer 24:1057–63, 1969). It is both an exophytic and endophytic papillary lesion histologically resembling syringocystadenoma papilliferum of sweat gland. The tumor is considered benign although rare recurrent cases have been reported. Three cases of malignant transformation of sialadenoma papilliferum have been described in the literature. We report a high grade mucoepidermoid carcinoma arising in a background of sialadenoma papilliferum, at the base of the tongue, an unusual location for minor salivary gland neoplasms. Eleven months after excision and nodal dissection, there is no evidence of recurrence or metastasis.

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Sialadenoma papilliferum

Cited by 31 publications

References 8 publications

Sialadenoma papilliferum: clinicopathologic, Immunohistochemical, molecular analyses of new five cases and review of the literature

Sialadenoma papilliferum: clinicopathologic, Immunohistochemical, molecular analyses of new five cases and review of the literature

Sialadenoma papilliferum: Bibliometric analysis

Mucoepidermoid Carcinoma Arising in a Background of Sialadenoma Papilliferum: A Case Report

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