Sialadenoma papilliferum of bronchus

Bobos, Mattheos; Hytiroglou, Prodromos; Karkavelas, Georgios; Papakonstantinou, Christos; Papadimitriou, Constantine S.

doi:10.1007/s00428-003-0879-y

Cited by 25 publications

(41 citation statements)

References 7 publications

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“…The proliferating epithelial cells are benign, and the lung distal to the bronchial tumor has histological features compatible with obstructive pneumonia without malignant findings. In the present case the outer lining cells of the double‐layer epithelium of the glandular structures were positive for CK5/6, CK14, vimentin, p63 and S‐100 protein (rare positive foci), and negative for CK8/18, α‐SMA, calponin or GFAP on immunohistochemistry, indicating characteristics of basal or basal/myoepithelial cells 21 rather than fully differentiated αSMA‐positive myoepithelial cells described in the previously reported case 13 …”

Section: Discussionsupporting

confidence: 76%

See 1 more Smart Citation

Sialadenoma papilliferum of the bronchus: Rare tracheobronchial tumor of salivary gland type

Honda

Shiraishi

Ishihara

et al. 2009

Pathology International

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Presented herein is the second case of sialadenoma papilliferum of the bronchus in a 75-year-old man. The bronchial tumor had an exophytic papillary lesion protruding into the lumen of the ostial region of the right superior lobe bronchus on chest CT and bronchoscopy. Grossly, the resected tumor was pedunculated, 5 x 3 x 3 mm in size and consisted of both an exophytic papillary lesion protruding into the bronchial lumen and a glandular component in the bronchial submucosa. Histologically, the papillary structures were lined by ciliated or non-ciliated columnar epithelium and metaplastic non-keratinizing stratified squamous epithelium. The submucosal glandular components were well circumscribed beneath and in continuity with the papillary lesion. The glandular components of cysts and duct-like structures were lined by a double-layer epithelium composed of luminal cells and basal cells. Sialadenoma papilliferum is a rarely recognized salivary gland tumor, mostly occurring at intraoral mucosal sites including the hard and soft palate and buccal mucosa. There have been sporadic cases of sialadenoma papilliferum of the esophagus, nasopharynx and nasal cavity. To the authors' knowledge only one case of sialadenoma papilliferum of the bronchus has been reported previously.

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Section: Discussionsupporting

confidence: 76%

“…The resected lymph nodes were negative for metastasis. The patient was well at 8 months following surgical resection 13 …”

Section: Discussionmentioning

confidence: 94%

Sialadenoma papilliferum of the bronchus: Rare tracheobronchial tumor of salivary gland type

Honda

Shiraishi

Ishihara

et al. 2009

Pathology International

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“…The junction of hard and soft palate is most frequently affected, other intraoral sites are the buccal mucosa, retromolar pad, lip, and parotid gland1, although rarely SP has been reported in broncheal 12 and esophageal 14 mucosa. This tumor is best treated by conservative surgical excision.…”

Section: ⅲ Discussionmentioning

confidence: 99%

Sialadenoma papilliferum: a case report and immunohistochemical study review

Byun

Kim

et al. 2010

J Korean Assoc Oral Maxillofac Surg

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Sialadenoma papilliferum (SP) is a rare benign neoplasm that normally arises from the minor salivary glands, particularly in the palate. SP is normally encountered in older men with an exophytic papillary surface growth. In the present study, an SP of the hard palate of a 69-year-old woman was examined immunohistochemically. Myoepithelial cell markers, such as S-100, smooth muscle actin and vimentin, were observed in the basal or luminal layer of tumor cells, indicating that myoepithelial cells participate in the pathogenesis of SP. In addition, cytokeratin 7 was also strongly detected in the tumor cells, suggesting that excretory ductal epithelial cells have a role in its histogenesis. A review of the literature of immunohistochemical studies on SP showed that the expression and co-expression of cytokeratins and myoepithelial cell markers have been reported in tumor cells. These results suggested that excretory duct cells and myoepithelial cells participate in the pathogenesis of SP.Key words: Sialadenoma papilliferum, Hard palate, Immunohistochemistry.[paper submitted 2010. 8. 27 / revised 2010. 11. 30 / accepted 2010. 12. 17] Abstract (J Korean Assoc Oral Maxillofac Surg 2010;36:533-7) *These two authors contributed equally to this work.

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“…The palate, and often at the junction between the hard and soft palate, is the most common location (80 %) followed by the buccal mucosa. Major salivary gland involvement is very rare with only a few cases described in the parotid gland; however, also other sites have been described such as the bronchus [ 19 ] and nasopharynx [ 64 ]. In their review of the literature in 2007, Mahajan et al found a total of only 47 cases reported.…”

Section: Ductal Papillomamentioning

confidence: 99%