Signal On–Off Electrochemical Sensor for Glutathione Based on a AuCu-Decorated Zr-Containing Metal–Organic Framework via Solid-State Electrochemistry of Cuprous Chloride

Abstract

A novel signal on−off glutathione (GSH) electrochemical sensor was developed based on a AuCu bimetaldecorated Zr-containing metal−organic framework (Zr-MOF), in which a signal amplification strategy promoted by solid-state electrochemistry of cuprous chloride (CuCl) was used. The Zr-MOF with a large surface area can be effectively used as the substrate for the in situ growth of AuCu bimetals to obtain the Zr-MOF@AuCu nanocomposite. The interaction between Cu in Zr-MOF@AuCu and Cl − in the solution accompanied with the formation of CuCl displays an enlarged stable oxidation current, which greatly declines with the addition of GSH owing to the specific Cu−GSH interaction. The conversion of CuCl into Cu-GSH triggered the "crowding-out effect" and resulted in a sharp drop in the peak current of CuCl, which can realize the ultrasensitive and selective detection of GSH. The detection mechanism was investigated, and the detection range was 10 pM−1 mM with the detection limit as low as 2.67 pM. The special response mechanism for the detection of GSH allows the highly selective detection of GSH in various real samples with reliable results, endowing the proposed electroanalysis sensor with broad application prospects in biological and food analysis.

Studies on Structural Changes of Modified MWCNTs: Material for Electrochemical Monitoring of Antiviral Drug in Human Serum Samples

“…Further, the IUdR was quantified by Hg/KR‐1@MWCNT /GCE on CV by adding IUdR in the linear range of 0.025 μM–250 μM (Figure 6B). The outcome from CV reveals that anodic peak current intensity decreases with increasing concentration of IUdR with a potential shift 0.45 V to 0.33 V due to the crowding out effect caused by IUdR [37] . The linear regression plot in Figure 6(C) indicates a linear relationship with the concentration of IUdR.…”

“…The outcome from CV reveals that anodic peak current intensity decreases with increasing concentration of IUdR with a potential shift 0.45 V to 0.33 V due to the crowding out effect caused by IUdR. [37] The linear regression plot in Figure 6 Ip,c[μA] at À 0.72 V = 0.1783[IUdR]/μMÀ 47.948 with R 2 = 0.9674. The limit of detection was found to be 13.8 nM calculated by 3sigma method.…”

Ammonia Modified MXene/Aniline Copolymers Electrochemical Sensors for Ultrasensitive Sensing Glutathione

“…Zr-MOF@AuCu/ MWCNT/GCE DPV 2.67 × 10 À 9 1 × 10 À 8 -1 × 10 À 3 [38] PTA/GCE DPV 5.21 × 10 À 14 1.0 × 10 À 12 -1.0 × 10 À 8…”

Ultrabright Green-Emissive Nanodots for Precise Biological Visualization

“…36−38 Because of the biological importance of GSH, developing an ideal GSH detection and visualization probe is important. However, most of the existing GSH detection strategies (e.g., electrochemistry, 39,40 high-performance liquid chromatography, 41,42 and surface-enhanced Raman scattering 43−45 ) need complicated operation steps and expensive equipment, and have relatively low sensitivity and selectivity (mainly influenced by other thiol group-containing molecules). The development of a GSH probe with satisfactory detection performance is urgently needed.…”