2020
DOI: 10.12750/jarb.35.2.155
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Signal transduction of C-terminal phosphorylation sites for equine follicle stimulating hormone receptor (eFSHR)

Abstract: The family of glycoprotein hormone receptors including follicle stimulating hormone receptor (FSHR) and lutropin chorionic gonadotropin hormone receptor (LH/CGR) belongs to the superfamily of G protein-coupled receptors (GPCR) that couple extracellular agonists to intracellular effector molecules through the reactions of heterotrimetric G proteins and arrestins (Schlador and Nathanson, 1997;Pierce et al., 2002;Wan et al., 2018). These heterotrimeric G proteins are broadly divided into four families (Gs, Gi/o, … Show more

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Cited by 2 publications
(10 citation statements)
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“…Recently, we also reported that eel FSHR-t635, in which all potential phosphorylation sites in the intracellular cytoplasmic tail were deleted, displayed an EC 50 of approximately 60.4% of that of eel FSHR-wt ( Kim et al, 2018 ). Although the rFSHR-truncated mutant did not affect phosphorylation or uncoupling ( Hipkin et al, 1995a ), the eFSHR-t641 in our study was considerably affected by cAMP responsiveness in cells expressing eFSHR-t641 with β -arrestin ( Seong et al, 2020 ). Our data in the present study are consistent with that in our previous study, indicating that the deletion mutant of the C-terminal region greatly decreased the cAMP response.…”
Section: Discussioncontrasting
confidence: 64%
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“…Recently, we also reported that eel FSHR-t635, in which all potential phosphorylation sites in the intracellular cytoplasmic tail were deleted, displayed an EC 50 of approximately 60.4% of that of eel FSHR-wt ( Kim et al, 2018 ). Although the rFSHR-truncated mutant did not affect phosphorylation or uncoupling ( Hipkin et al, 1995a ), the eFSHR-t641 in our study was considerably affected by cAMP responsiveness in cells expressing eFSHR-t641 with β -arrestin ( Seong et al, 2020 ). Our data in the present study are consistent with that in our previous study, indicating that the deletion mutant of the C-terminal region greatly decreased the cAMP response.…”
Section: Discussioncontrasting
confidence: 64%
“…Two deleted mutants (rLHR-t628 and rLHR-t631) in the rLHR C-terminus are involved in the protein kinase A (PKA) signaling pathway, desensitization, and downregulation by phorbol 12-myristate-13-acetate (PMA) and human chorionic gonadotropin (hCG) treatment ( Sánchez-Yagüe et al, 1992 ; Wang et al, 1996 ). Recently, we also reported that EC 50 and R max levels of the equine FSHR (eFSHR)-t641 mutant, which removed 10 potential phosphorylation sites, were 0.58-fold and 68.4% of that in eFSHR-wt ( Seong et al, 2020 ). The EC 50 level of eel FSHR-t614 mutant, in which 10 phosphorylation sites in the C-terminal region were deleted, was approximately 60.4% in Chinese hamster ovary (CHO) -K1 cells, and the maximal response was drastically lower than that of eel FSHR-wt ( Kim et al, 2018 ).…”
Section: Introductionmentioning
confidence: 97%
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“…36, No. 2, June 2021 100 mone, seasonal effect to reproductive organ, device for controlling seasonal effect and biotechnology for embryo transfer (Park et al, 2017;Yu et al, 2017;Lee et al, 2020;Seong et al, 2020). Especially, the foaling is considered as one of main topics among several fields of reproductive physiology of mares.…”
Section: Introductionmentioning
confidence: 99%