Signet ring cell carcinoma of the stomach

Maehara, Yoshihiko; Sakaguchi, Yoshihisa; Moriguchi, Satoru; Orita, Hiroyuki; Korenaga, Daisuke; Kohnoe, Shunji; Sugimachi, Keizō

doi:10.1002/1097-0142(19920401)69:7<1645::aid-cncr2820690702>3.0.co;2-x

Cited by 133 publications

(95 citation statements)

References 14 publications

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“…The prevalence of GSRC among patients with gastric cancer has been reported to range from 3.4 to 39% [1][2][3], and, in South Korea, incidences of 12.2 and 8.7% have been reported [4,5]. One group of researchers reported that GSRC shows a slightly higher predominance among females and younger individuals [1], whereas others have found no gender difference [3,[5][6][7]. From the prognostic point of view, several authors have demonstrated that GSRC does not have a poorer prognosis than the other types of stomach cancer [1,2,5,7], but the issue remains controversial.…”

Section: Introductionmentioning

confidence: 99%

“…One group of researchers reported that GSRC shows a slightly higher predominance among females and younger individuals [1], whereas others have found no gender difference [3,[5][6][7]. From the prognostic point of view, several authors have demonstrated that GSRC does not have a poorer prognosis than the other types of stomach cancer [1,2,5,7], but the issue remains controversial. Others have suggested that, among advanced gastric cancers, GSRC has a poorer prognosis [4,6].…”

Section: Introductionmentioning

confidence: 99%

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Relation Between Fluorodeoxyglucose Uptake and Glucose Transporter-1 Expression in Gastric Signet Ring Cell Carcinoma

Choi

Song

et al. 2010

Nucl Med Mol Imaging

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Purpose Gastric signet ring cell carcinoma (GSRC) is known to have low fluorodeoxyglucose (FDG) uptake. The aim of the study was to investigate the relation between FDG uptake and glucose transporter (GLUT)-1 expression and clinicopathologic parameters in cases of GSRC. Materials and Methods Forty patients (28 men, mean age 54±12 years) with histologically confirmed GSRC who underwent pre-operative [18 F]FDG PET/CT were enrolled. Maximum standardized uptake values (SUVmax) were compared with clinicopathologic parameters and GLUT-1 expression. Cases were divided based on GLUT-1 expression in tumor tissues into a membranous group (n=17) and a cytoplasmic group (n=23). Results Mean SUVmax was significantly higher in the membranous group than in the cytoplasmic group (6.06± 2.79 vs. 3.67±1.54, P=0.03). Gastric wall invasion, depth of invasion, extent of LN metastasis, overall stage, and tumor size were found to be related to SUVmax. On the other hand, age, sex, and the presence of distant metastasis were not related to SUVmax. Multivariate analysis revealed that membranous GLUT-1 expression and the extent of LN metastasis independently predicted high FDG uptake. Conclusions This study demonstrates that high FDG uptake is mediated by membranous GLUT-1 expression in GSRC.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Relation Between Fluorodeoxyglucose Uptake and Glucose Transporter-1 Expression in Gastric Signet Ring Cell Carcinoma

Choi

Song

et al. 2010

Nucl Med Mol Imaging

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“…1 The prognosis after surgery for early gastric carcinoma generally is favorable, with the 5-year survival rate at present exceeding 90% in Japan. 2 However, there are cases of recurrence: The rate in cases of early gastric carcinoma is 2.2%. 3 We reported previously that the growth pattern based on a volumetric analysis is an important prognostic factor in early gastric carcinoma.…”

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confidence: 98%

Intratumoral neovascularization and growth pattern in early gastric carcinoma

Tomoda

Maehara

Kakeji

et al. 1999

Cancer

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“…The great majority of mutations in the p53 gene are missense in type, leading to production of full-length proteins with an altered conformation and abnormal biological properties (Hollstein et al, 1991). Unlike the wild-type protein, which has a short halflife, the great majority of tetramers containing mutant protein are stable and therefore readily detectable by immunochemistry using antibodies reactive to p53 (KikuchiYanoshita et al, 1992 Cancer, 1981Cancer, , 1993Maehara et al, 1992 (Kakeji et al, 1993 (Table II).…”

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confidence: 99%

A tumour-associated cell-surface glycoprotein accompanying p53 overexpression and higher growth potential for gastric cancer

Maehara

Okuyama²,

Kakeji³

et al. 1995

Br J Cancer

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S aryTumour-associated cell-surface glycoprotein is associated with tumour progression in gastric cancer. We investigated the biological significance of tumour-associated cell-surface glycoprotein, determined by the binding of Helix pomatia agglutinin (HPA), with regrd to survival time and to the malignant potential of cancer cells in serosally invasive gastric cancer in 119 patients. HPA was positively stained in 75 of 119 patients (63.0%) with gastric cancer with serosal invasion. In patients with HPA-positive tissue, the tumour was larger than in HPA-negative cases and was frequently located in the middle third of the stomach. The incidence of lymph node metastasis was higher than in patients with HPA-negative tissue. There were no differences between the cases staining negatively and positively with HPA with respect to the other factors eained. Gastric cancer tissues with HPA-positive staining revealed a higher positive rate of abnormal p53 staining and a higher concentration of proliferating cell nuclear antigen (PCNA) labelling. The survival time of the patients with HPA positive staining was shorter than for those whose tissues were HPA negative. Thus, tumour-associated cell-surface glycoprotein is apparently closely related to the malignant potential of serosally invasive gastnc cancer.

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Signet ring cell carcinoma of the stomach

Cited by 133 publications

References 14 publications

Relation Between Fluorodeoxyglucose Uptake and Glucose Transporter-1 Expression in Gastric Signet Ring Cell Carcinoma

Relation Between Fluorodeoxyglucose Uptake and Glucose Transporter-1 Expression in Gastric Signet Ring Cell Carcinoma

Intratumoral neovascularization and growth pattern in early gastric carcinoma

A tumour-associated cell-surface glycoprotein accompanying p53 overexpression and higher growth potential for gastric cancer

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