Significance of physical exercise in hypertension. Influence of water temperature and beta-blockade on blood pressure, degree of cardiac hypertrophy and cardiac function in swimming training of spontaneously hypertensive rats

Vogt, M.; Ott, B.; Rupp, Heinz; Jacob, R.

doi:10.1007/978-3-662-11374-5_16

Cited by 8 publications

(5 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results also showed that the blood pressure is normal in WKY rats while hypertension occurs in SHR. After 6-week load-free swimming, the blood pressure decreased significantly in SHR, which was consistent with other studies (10,11). Recent research found that aerobic physical activity may alter the aortic wall remodeling to adapt the artery to a hyperkinetic blood flow resulting in alterations of the extracellular matrix modulation and vascular resistance (4).…”

Section: Discussionsupporting

confidence: 89%

Aortic wall proteomic analysis in spontaneously hypertensive rats with a blood pressure decrease induced by 6-week load-free swimming

Hong

Li²,

Zhang

et al. 2015

Biomedical Reports

View full text Add to dashboard Cite

Abstract. Decreased arterial compliance is one of the earliest detectable manifestations of adverse structural and functional changes within the vessel wall in hypertension. The proteomic approach is a powerful technique to analyze a complex mixture of proteins in various settings. Physical activity level was negatively associated with blood pressure. Sixteen 4-week-old male spontaneously hypertensive rats (SHR) and 16 Wistar-Kyoto (WKY) rats were randomly divided into four groups: i) SHR exercise group, ii) SHR rest group, iii) WKY exercise group and iv) WKY rest group. In the SHR and WKY exercise groups, rats were treated with a 6-week load-free swimming protocol (1 h/day, 5 days/week). The blood pressure of the rats was tested by the CODA TM2 single non-invasive blood pressure measurement appliance. After the 6-week swimming protocol, the total aorta excluding abdominal aorta was extracted. The proteins were separated by two-dimensional gel electrophoresis and identified via LC-mass spectrometry (MS)/MS. After 6-week load-free swimming, blood pressure decreased in the SHRs. Compared with sedentary SHRs, 11 spots on the 2D-gel showed a significant difference in exercised SHRs. Nine of these were chosen for further identification. There were 5 upregulated proteins (long-chain specific acyl-CoA dehydrogenase, heat shock protein β-1, isocitrate dehydrogenase subunit α, actin, α cardiac muscle 1 preprotein and calmodulin isoform 2) and 4 downregulated proteins (adipocyte-type fatty acid-binding protein, tubulin β-2C chain, 78 kDa glucose-regulated protein precursor and mimecan). Proteomics is an effective method to identify the target proteins of exercise intervention for hypertension. IntroductionHypertension is the most frequent chronic disease in the developed world. It is a multisystemic disease that affects the heart and kidneys among other organs. The overall functional, structural and biochemical alterations in vasculature have been extensively studied during hypertension, but the molecular mechanisms remain unclear. Decreased arterial compliance is one of the earliest detectable manifestations of adverse structural and functional changes within the vessel wall (1). It has been shown that the proteomic approach is a useful technique to analyze a complex mixture of proteins in various settings, usually by combining two-dimensional electrophoresis and mass spectrometry (MS) (2). Bian et al (3) recently analyzed the proteome of aorta from spontaneously hypertensive rats (SHR). They found that SHR showed a significant alteration in the aortic wall protein profile compared with normal rats.Exercise is a key antihypertensive therapy. It is reported that the physical activity level was negatively associated with blood pressure. In addition, the blood pressure can be decreased with long-term physical activity. Blood pressure of SHRs undergoing the physical activity protocol was lower than that of the normal SHRs. The functional and structural alterations in vasculature occurred in hypertensives following exercise t...

show abstract

Section: Discussionsupporting

confidence: 89%

Aortic wall proteomic analysis in spontaneously hypertensive rats with a blood pressure decrease induced by 6-week load-free swimming

Hong

Li²,

Zhang

et al. 2015

Biomedical Reports

View full text Add to dashboard Cite

show abstract

“…Moreover, the SBP of untrained rats presented a significant elevation (SHR-C; Δ 13.5 mmHg − 1 ) at the end of the experimental period (Table 1). This response is in accordance with several studies, where different exercise regimens and intensities are shown to reduce SBP and improve cardiovascular fitness [48,49,[56][57][58], also contributing to interrupt pathological hypertrophy in SHR rats [59]. Besides LVH, other pathologic parameters such as collagen and wallto-lumen ratio were also shown to be reduced in hypertensive rats after treadmill training [60].…”

Section: Discussionsupporting

confidence: 88%

NanoUPLC/MSE proteomic analysis reveals modulation on left ventricle proteome from hypertensive rats after exercise training

Petriz

Almeida

Gomes

et al. 2015

Journal of Proteomics

View full text Add to dashboard Cite

“…Several investigators have reported either a significant increase in BP, or a trend towards it, following treadmill running, swimming or voluntary wheel running [17,24,49], while others did not find any significant differences [10,42]. These differences between studies may be related to several factors including differences in training intensity, duration, mode [47], stress [28] and environment [52]. The mechanism behind the increase in BP in exercised rats is not known.…”

Section: Discussionmentioning

confidence: 93%

Exercise training enhanced the expression of myocardial proteins related to cell protection in spontaneously hypertensive rats

Lajoie

Calderone

Béliveau

2004

Pflugers Arch - Eur J Physiol

View full text Add to dashboard Cite

Exercise training could potentially exert beneficial effects on the signaling events associated with cardiac cell apoptosis. Spontaneously hypertensive rats (SHR) were trained 5 days/week on a treadmill (18 m/min for 120 min/day) between the ages of 4 weeks and 1 week, corresponding to the hypertensive accelerating phase. The effect of exercise training on the expression of anti-apoptotic proteins HSP-72, Bcl-2 and protein kinase B (PKB), and the apoptotic proteins Bax and glycogen synthase kinase-3 (GSK-3) was examined. Exercise had a significant acute lowering effect on blood pressure, but this decrease did not attenuate the progressive increase in blood pressure. In the left ventricles of exercised SHR, PKB phosphorylation of both Ser473 and Thr308 residues was significantly increased by 166% and 120%, respectively, compared to sedentary SHR. PKB phosphorylation significantly correlated with GSK-3beta phosphorylation. HSP-72 and Bcl-2 protein expression were increased in the left ventricle of exercised SHR, and associated with the concomitant increased expression of the protein Bax. Thus, the Bcl-2/Bax ratio was not changed by exercise training, suggesting that the anti-apoptotic mechanism was effective in compensating the increase in the expression of the pro-apoptotic protein Bax in the myocardium of the SHR.

show abstract

Significance of physical exercise in hypertension. Influence of water temperature and beta-blockade on blood pressure, degree of cardiac hypertrophy and cardiac function in swimming training of spontaneously hypertensive rats

Cited by 8 publications

References 27 publications

Aortic wall proteomic analysis in spontaneously hypertensive rats with a blood pressure decrease induced by 6-week load-free swimming

Aortic wall proteomic analysis in spontaneously hypertensive rats with a blood pressure decrease induced by 6-week load-free swimming

NanoUPLC/MSE proteomic analysis reveals modulation on left ventricle proteome from hypertensive rats after exercise training

Exercise training enhanced the expression of myocardial proteins related to cell protection in spontaneously hypertensive rats

Contact Info

Product

Resources

About