Sildenafil citrate as a phosphodiesterase inhibitor has an antioxidant effect in the blood of men

Abstract

Treatment of blood with 100 mg sildenafil citrate has protective effects on oxidative stress by inhibiting free radical formation and by supporting antioxidant redox systems.

Assessment of the acute effects of tadalafil on the cardiovascular system based on examination of serum oxidative status and paraoxonase activity in men with erectile dysfunction: a preliminary study

“…26 One placebo-controlled study found that 100 mg sildenafil citrate had a beneficial effect on the serum oxidative status of subjects without any health problems; the effect lasted for about a day. 11 Another study reported the same conclusion in an animal model of passive-smoking-induced ED. 12 Our results on the oxidative status of patients with ED support these findings for tadalafil citrate; additionally, although we did not measure data more than 2 h after drug administration, we propose that the reduction in serum oxidative stress may last more than a day, given that tadalafil citrate has a longer serum half-life than sildenafil citrate.…”

“…Studies on the beneficial effects of PDE5 inhibitors on endothelial functions and their contribution to vascular repair have provided justification for the expansion of the indication spectrum. 11,12,20,21 Paradoxically, the associations of PDE5 inhibitors usage and some life-threatening events, such as acute MI and stroke, in connection with some disorders, such as cardiac arrhythmias, hypo/hypertension, are related to the cardiac and neurovascular systems. 7,8 Nevertheless, recent reports strongly suggest that there is no increase in the incidence of acute MI or death rates during sexual activity while using PDE5 inhibitors.…”

“…10 In some of these studies, sildenafil citrate was shown to have protective effects on oxidative stress by inhibiting free radical formation and supporting antioxidant redox systems; this reduction in oxidative stress is the supposed reason behind the improvement in endothelial function. 11,12 However, to the best of our knowledge, the effect of PDE5 inhibitors on paraoxonase, which is closely related to serum oxidative status and cardiovascular and endothelial functions, has not yet been reported.…”

Targeting phosphodiesterase 5 as a therapeutic option against myocardial ischaemia/reperfusion injury and for treating heart failure

“…It has been shown that oxidative stress increases the expression of PDE5 in the cardiomyocytes of failing hearts (Lu et al, 2010) and sildenafil attenuated oxidative stress by inhibiting free radical formation and by facilitating antioxidant redox systems (Bivalacqua et al, 2009;Perk et al, 2008). One of the mechanisms of action of PDE inhibitors might be to reduce oxidative stress levels, as PDE levels are up-regulated in conditions such as pulmonary hypertension, chronic HF and right ventricular hypertrophy (Corbin et al, 2005;Forfia et al, 2007;Nagendran et al, 2007) and oxidative stress mediates the dysfunctional NO-cGMP-PKG signalling in cardiovascular disease.…”

Can Colorectal Cancer be Prevented or Treated by Oral Hormone Replacement Therapy?

“…a Reversion of the tumorigenic phenotype by GCC is generalizable, reproduced in numerous human and mouse colon cancer cell lines. a Of significance, activation of GCC signaling suppresses ROS production, a reflecting increased function of the electron transport chain [70][71][72] or increased production of ROS scavengers, [73,74]and promotes genetic stability. a Interestingly, a study [10] using Apc Min/+ mice suggested that supplementation of uroguanylin significantly suppressed intestinal tumorigenesis, including tumor initiation and progression.…”