Silica/alginate hybrid biomaterials and assessment of their covalent coupling

Abstract

Organic–inorganic hybrid materials composed of co-networks of biodegradable polymer and silica have potential to combine the properties of an elastic organic polymer and inorganic silica. The nanoscale interaction of the co-networks and formation of covalent bonds between them are expected to provide tailored mechanical properties and congruent degradation. Alginate is a natural polymer commonly used in tissue engineering applications due to its good biocompatibility and biodegradability. In this work we present new alginate–silica hybrids prepared through nucleophilic ring opening reaction of 3-glycidoxypropyl trimethoxysilane (GPTMS) by carboxylic groups of alginate and incorporation of this functionalized alginate into the sol–gel process to make a hybrid. The role of the GPTMS is to provide organic/inorganic covalent coupling. The reaction of alginate with GPTMS was followed using NMR, FTIR and ToF-SIMS and the dissolution behaviour, bioactivity and mechanical properties of the resultant alginate–silica hybrid monoliths were evaluated. While mechanical strength was high with values of 110–242 MPa comparable to that of cortical bone, the amount of GPTMS coupling to the alginate was low, with the rest of the GPTMS forming diols or a separate network

Sequestration of Sulfate Anions from Groundwater by Biopolymer-Metal Composite Materials

“…Figure S3). These XRD features provide support that chitosan exists in a semi-crystalline form [77]. By contrast, alginate shows a comparatively sharp band at 2θ = 32 • .…”

A review of chitosan-, alginate-, and gelatin-based biocomposites for bone tissue engineering

“…For the 3-glycidoxypropyl trimethoxysilane samples, the compressive strength and the strain to failure enhanced. These results indicated that these biomaterials have potential for BTE (Vueva et al, 2018).…”

“…The above-mentioned results are summarized in Table 5. (Shaheen et al, 2019) hydroxyapatite-alginatechlorhexidine increased degree of swelling and decreased shape stability due to alginate content (Sukhodub et al, 2018) poly(lactic-co-glycolic acid)magnesium oxide-alginate coreshell microspheres enhanced MC3T3-E1 pre-osteoblasts viability and new bone formation (75% bone volume) with good Young's modulus of the regenerated bone in Sprague-Dawley female rats (Lin et al, 2018) -tricalcium phosphate-alginate increased compressive strength (Czechowska et al, 2018) alginate/sulfated alginate bioinks good rheologic properties, improved release and activity of BMP2 (MC3T3-E1 osteoblasts -enhanced proliferation and osteogenesis), good results regarding metabolic and ALP activity and calcium deposition; (Park et al, 2018) Calcium/Strontium-alginate enhanced stability and improved proliferation of the hMSCs for higher content of Sr 2+ (Catanzano et al, 2018) Calcium carbonate-alginate improved hydrogel stability and enhanced cell viability for alginate with intermediate content of G blocks (Diaz-Rodriguez et al, 2018) silica-alginate and 3glycidoxypropyl trimethoxysilane rapid silicon release for high contents of 3-glycidoxypropyl trimethoxysilane and decreased dissolution time due to the addition of calcium ions (Vueva et al, 2018) 4.3. Gelatin-based biomaterials…”

Microwave-Assisted Fabrication of Mesoporous Silica-Calcium Phosphate Composites for Dental Application

“…The heterogeneous nature of calcium phosphate precipitation on biomaterial surface is a well-known phenomenon that promotes further biomineralization [ 52 , 65 , 66 , 67 ]. For SBA-CaP(MW)_S1-S2 samples, a calcium-deficient hydroxyapatite (CDHA) was detected with so-called cauliflower morphology [ 68 ] and approx. 1.42 Ca/P molar ratio, whereas for SBA-CaP(MW)_S3 sample, the plate-like particles of octacalcium phosphate (OCP) [ 60 , 69 ] with adequate Ca/P ~1.32 were observed.…”