Microwave-Assisted Fabrication of Mesoporous Silica-Calcium Phosphate Composites for Dental Application

Abstract

Herein, the microwave-assisted wet precipitation method was used to obtain materials consisting of mesoporous silica (SBA-15) and calcium orthophosphates (CaP). Composites were prepared through immersion of mesoporous silica in different calcification coating solutions and then exposed to microwave radiation. The composites were characterized in terms of molecular structure, crystallinity, morphology, chemical composition, and mineralization potential by Fourier-transform infrared spectroscopy (FTIR), powder X-ray diffraction (XRD), and scanning electron microscopy equipped with energy-dispersive X-ray spectroscopy (SEM-EDX). The application of microwave irradiation resulted in the formation of different types of calcium orthophosphates such as calcium deficient hydroxyapatite (CDHA), octacalcium phosphate (OCP), and amorphous calcium phosphate (ACP) on the SBA-15 surface, depending on the type of coating solution. The composites for which the progressive formation of hydroxyapatite during incubation in simulated body fluid was observed were further used in the production of final pharmaceutical forms: membranes, granules, and pellets. All of the obtained pharmaceutical forms preserved mineralization properties.

Distinct Methodologies to Produce Capped Mesoporous Silica with Hydroxyapatite and the Influence in Intracellular Signaling as Cytotoxicity on Human Umbilical Vein Endothelial Cells

“…Characteristic reflections peak positions from planes of the pure HAP phase are indicated in Figure 7. According to Prokopowicz et al [41] and corroborated by Szewczyk et al [42], the WXRD analysis of mesoporous silica capped with hydroxyapatite is confirmed with the absence of two peaks at 2θ ≈ 4.69 and 5.30, which are typical for (110) and (200) reflections.…”

Dopamine-Assisted Modification of Polypropylene Film to Attain Hydrophilic Mineral-Rich Surfaces

“…Presumably, those formations were attributed to the silica coatings. Szewczyk et al [ 34 ] mentioned that the self-formed hydroxyapatite in vitro ranges typically from 30 to 60 days to cover the mesoporous silica fully. Since the roughness affects the anchoring and attachment property [ 35 ], the CaP deposition could eventually start in our case if the immersion of the sample in SBF were to continue.…”

Mesoporous Silica-Bioglass Composite Pellets as Bone Drug Delivery System with Mineralization Potential

“…Based on SEM-EDX, XRD, and FTIR results it might be concluded that obtained pellets were characterized by the ability to form a carbonate apatite surface layer after immersion in simulated body fluid. It has been emphasized in many studies that such self-formed biomimetic apatite constitutes a completely biocompatible scaffold for further regeneration of the defected bone site after implantation with no need for implant removal surgery [ 53 , 54 , 55 ].…”

“…In our previous works, we investigated different types of bone drug delivery systems with mineralization potential such as xerogels [ 56 , 57 ], membranes [ 23 , 29 ], powders [ 58 , 59 ], granules [ 55 ], and pellets [ 22 , 43 ]. In the case of previously described pellets, the mineralization potential was provided by either use of MCM-41-calcium phosphate composite [ 22 ] or the addition of hydroxyapatite synthesized via microwave-assisted hydrothermal precipitation method [ 43 ].…”