Silicon Nanoparticles as Amplifiers of the Ultrasonic Effect in Sonodynamic Therapy

Abstract

The possibility of using mesoporous silicon nanoparticles as amplifiers (sensitizers) of therapeutic ultrasonic exposure were studied experimentally in vitro and in vivo. The combination of nanoparticles and ultrasound led to a significant inhibition of Hep-2 cancer cell proliferation and Lewis lung carcinoma growth in mice. These results indicated good prospects of using silicon nanoparticles as sensitizers for sonodynamic therapy of tumors.

Optical methods of silicon nanoparticle diagnostics for applications in biomedicine

“…The Raman spectra of meso-PSi analyzed by using Eqs. (1)- (4) show that the average size of Si nanocrystals is about 5 nm and it does not practically change after the storage of the sample in aqueous solution. However, the contribution of the nanocrystalline phase becomes smaller and the signal of a-Si fraction increased (see Fig.…”

“…In recent years, various types of nanostructured forms of crystalline silicon (Si) have been intensively studied for application in technology and biomedicine, including for the diagnosis and therapy of various diseases [1,2]. Porous Si [3,[4][5][6][7], silicon nanowires [8], and nanoparticles (NPs) obtained from them [9], as well as laser-ablated Si NPs [2,10] and nanoparticles obtained from porous c-Si [11], have a great potential of unique physical and chemical properties for application both in tumor therapy [1,2,4,9] and as contrast agents for bioimaging [8,10,11].…”

Recent advances in nanomaterials for sonodynamic therapy

“…In addition to TiO2, Si nanostructures also have been widely used in SDT [123,124]. For example, Osminkina et al prepared Si nanowires (Si NWs, about 5 μm in length and 200 nm in diameter) via a cheap and efficient metal-assisted etching method [125].…”

Sonodynamic Therapy: Advances and Challenges in Clinical Translation

“…This combination resulted in the possibility of enhancing the sonodynamic activation in the treated site. Silicon nanoparticles were also shown to be efficient in producing a sonodynamic effect and led to significant growth inhibition of Hep‐2 cancer and Lewis carcinoma in mice …”