Silicon Nitride Bearings for Total Joint Arthroplasty

McEntire, Bryan J.; Lakshminarayanan, Rajamani; Ray, Darin; Clarke, Ian C.; Puppulin, Leonardo; Pezzotti, Giuseppe

doi:10.3390/lubricants4040035

Cited by 20 publications

(7 citation statements)

References 146 publications

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“…Therefore, in addition to the generation of Si 3 N 4 particles, tribochemical wear of Si 3 N 4 articulating surfaces could release particles with a surface composition similar to SiO 2 . Currently, tribochemical wear has been observed in hard-on-hard Si 3 N 4 bearings and ceramic-like coatings 6 , 12 , 13 . Tribochemical dissolution of Si 3 N 4 also offers a unique potential advantage, in that the wear particles that are released are slowly dissolved in biological fluids, reducing the overall particle load over the long-term use of a device 14 , 15 .…”

Section: Introductionmentioning

confidence: 99%

Biological Impact of Silicon Nitride for Orthopaedic Applications: Role of Particle Size, Surface Composition and Donor Variation

Lal

Caseley

Hall

et al. 2018

Sci Rep

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The adverse biological impact of orthopaedic wear debris currently limits the long-term safety of human joint replacement devices. We investigated the role of particle size, surface composition and donor variation in influencing the biological impact of silicon nitride as a bioceramic for orthopaedic applications. Silicon nitride particles were compared to the other commonly used orthopaedic biomaterials (e.g. cobalt-chromium and Ti-6Al-4V alloys). A novel biological evaluation platform was developed to simultaneously evaluate cytotoxicity, inflammatory cytokine release, oxidative stress, and genotoxicity potential of particles using peripheral blood mononuclear cells (PBMNCs) from individual human donors. Irrespective of the particle size, silicon nitride did not cause any adverse responses whereas cobalt-chromium wear particles caused donor-dependent cytotoxicity, TNF-α cytokine release, oxidative stress, and DNA damage in PBMNCs after 24 h. Despite being similar in size and morphology, silicon dioxide nanoparticles caused the release of significantly higher levels of TNF-α compared to silicon nitride nanoparticles, suggesting that surface composition influences the inflammatory response in PBMNCs. Ti-6Al-4V wear particles also released significantly elevated levels of TNF-α cytokine in one of the donors. This study demonstrated that silicon nitride is an attractive orthopaedic biomaterial due to its minimal biological impact on human PBMNCs.

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Section: Introductionmentioning

confidence: 99%

Biological Impact of Silicon Nitride for Orthopaedic Applications: Role of Particle Size, Surface Composition and Donor Variation

Lal

Caseley

Hall

et al. 2018

Sci Rep

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“…Recent hip simulator studies show that self-mated silicon nitride couples exhibit up to 3 million cycles of wear compared to self-mated alumina; however, some self-mated silicon nitride couples show increased wear at the end of 5 million cycles compared to alumina CoC [ 71 ]. Further long term clinical studies of retrieved heads of silicon nitride and hip simulator studies by others may be necessary.…”

Section: Materials Used In Bearing Surfacementioning

confidence: 99%

Recent updates for biomaterials used in total hip arthroplasty

Yoon

2018

Biomater Res

135

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BackgroundTotal hip arthroplasty (THA) is probably one of the most successful surgical interventions performed in medicine. Through the revolution of hip arthroplasty by principles of low friction arthroplasty was introduced by Sir John Charnley in 1960s. Thereafter, new bearing materials, fixation methods, and new designs has been improved. The main concern regarding failure of THA has been the biological response to particulate polyethylene debris generated by conventional metal on polyethylene bearing surfaces leading to osteolysis and aseptic loosening of the prosthesis. To resolve these problems, the materials of the modern THA were developed since then.MethodsA literature search strategy was conducted using various search terms in PUBMED. The highest quality articles that met the inclusion criteria and best answered the topics of focus of this review were selected. Key search terms included ‘total hip arthroplasty’, ‘biomaterials’, ‘stainless steel’, ‘cobalt-chromium’, ‘titanium’, ‘polyethylene’, and ‘ceramic’.ResultsThe initial search retrieved 6921 articles. Thirty-two articles were selected and used in the review.ConclusionThis article introduces biomaterials used in THA and discusses various bearing materials in currentclinical use in THA as well as the newer biomaterials which may even further decrease wear and improve THA survivorship.

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“…Bulk silicon nitrides in articulation against itself and Co-Cr materials have shown wear rates that are comparable to those of alumina-on-alumina couple, which are the lowest among currently used bearing couples [81]. A recent hip simulator study indicated that self-mated silicon nitride couples have comparable wear performance to that of self-mated alumina up to three million cycles; however, some self-mated silicon nitride couples showed increased wear at the end of five million cycles as compared to alumina CoC [82]. This transition in wear regime from fluid film to lubrication was attributed to the formation and disruption of tribochemical film composed of a gelatinous silicic acid.…”

Section: Silicon Nitridementioning

confidence: 99%

Progress in Wear Resistant Materials for Total Hip Arthroplasty

et al. 2017

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Current trends in total hip arthroplasty (THA) are to develop novel artificial hip joints with high wear resistance and mechanical reliability with a potential to last for at least 25-30 years for both young and old active patients. Currently used artificial hip joints are mainly composed of femoral head of monolithic alumina or alumina-zirconia composites articulating against cross-linked polyethylene liner of acetabular cup or Co-Cr alloy in a self-mated configuration. However, the possibility of fracture of ceramics or its composites, PE wear debris-induced osteolysis, and hypersensitivity issue due to metal ion release cannot be eliminated. In some cases, thin ultra-hard diamond-based, TiN coatings on Ti-6A-4V or thin zirconia layer on the Zr-Nb alloy have been fabricated to develop high wear resistant bearing surfaces. However, these coatings showed poor adhesion in tribological testing. To provide high wear resistance and mechanical reliability to femoral head, a new kind of ceramic/metal artificial hip joint hybrid was recently proposed in which 10-15 µm thick dense layer of pure α-alumina was formed onto Ti-6Al-4V alloy by deposition of Al metal layer by cold spraying or cold metal transfer methods with 1-2 µm thick Al 3 Ti reaction layer formed at their interface to improve adhesion. An optimal micro-arc oxidation treatment transformed Al to dense α-alumina layer, which showed high Vickers hardness 1900 HV and good adhesion to the substrate. Further tribological and cytotoxicity analyses of these hybrids will determine their efficacy for potential use in THA.

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Silicon Nitride Bearings for Total Joint Arthroplasty

Cited by 20 publications

References 146 publications

Biological Impact of Silicon Nitride for Orthopaedic Applications: Role of Particle Size, Surface Composition and Donor Variation

Biological Impact of Silicon Nitride for Orthopaedic Applications: Role of Particle Size, Surface Composition and Donor Variation

Recent updates for biomaterials used in total hip arthroplasty

Progress in Wear Resistant Materials for Total Hip Arthroplasty

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