Silicones as Artificial Internal Tissue and Organ Substitutes

Mullison, Ethel G.

doi:10.1111/j.1749-6632.1965.tb30683.x

Cited by 5 publications

(1 citation statement)

References 26 publications

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“…Silicone elastomers are used extensively in biomedical applications including contact lenses,29 catheters,2 heart valves,30 artificial limbs31 and breast implants 13. It is good optical clarity, transparency, low permeability to water and thermal stability contribute to making it a highly desirable biomaterial for a variety of applications 15.…”

Section: Discussionmentioning

confidence: 99%

Plasma Polymer Coatings to Support Mesenchymal Stem Cell Adhesion, Growth and Differentiation on Variable Stiffness Silicone Elastomers

Colley

Mishra

Scutt

et al. 2009

Plasma Processes & Polymers

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The mechanical properties of the underlying substratum have previously been shown to affect a number of cellular processes including locomotion, proliferation and differentiation. Although polyacrylamide is the most studied variable‐stiffness substrate, silicone elastomers offer a more physiologically relevant range of moduli. Here, we employ plasma polymerisation to apply an acid‐containing polymer thin film to silicone elastomer substrates. This simple one‐step surface modification process renders the surfaces hydrophilic and does not require the introduction of extracellular matrix (ECM) proteins commonly used as modification agents to support cell attachment. Contact angle and XPS analysis demonstrates that the coating chemistry is consistent across all of the materials and critically, we show that the addition of this coating does not alter the underlying mechanical properties of the elastomer. The surface modification supports mesenchymal stem cell (MSC) adhesion to a level that is comparable to that seen for tissue culture polystyrene (TCPS). When used as a variable‐stiffness substrate to study cell behaviour we demonstrate that MSC proliferation is unaltered but osteogenic differentiation varies with substrate stiffness.

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Section: Discussionmentioning

confidence: 99%

Plasma Polymer Coatings to Support Mesenchymal Stem Cell Adhesion, Growth and Differentiation on Variable Stiffness Silicone Elastomers

Colley

Mishra

Scutt

et al. 2009

Plasma Processes & Polymers

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Prosthetic urinary bladder implantation to facilitate bladder regeneration

Dørflinger

Frimodt‐Møller

England

et al. 1985

Neurourology and Urodynamics

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A temporary artificial bladder was implanted in 15 female dogs undergoing total or subtotal cystectomy. One or two months after implantation, the prosthesis was removed. In three dogs sacrificed 6 months after prosthesis implantation, a new urinary reservoir was identified. Two dogs failed to develop a urinary reservoir, and both ureters anastomosed directly to the top of a dilated urethra. Seven dogs died from complications (infection, urine leakage, etc). Three additional dogs are alive and well 2.5 months after implantation, and in these animals a new urinary reservoir has been demonstrated by cystography. Histologic examination of the new urinary reservoir revealed a thin lining of transitional cell-like epithelium and an underlying attenuated muscle layer. The ability of the canine species to generate a functioning urinary reservoir after total or subtotal cystectomy may hold promise for eventual clinical application in humans.

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Silicones as biomaterials

Quinn¹,

Courtney

1988

Brit. Poly. J.

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Silicon has the ability to form polymeric chains, commonly linear chains of dimethylsiloxane, although other organic groups can be substituted for methyl. In addition, the properties of the resultant silicone polymers can vary with composition and curing procedure. This leads to a wide range of materials known as the silicones. This group of polymers, which have excellent biocompatibility, have been utilised to develop and manufacture a wide range of biomedical products. These range from simple tubing to complex implants, for example those used to replace diseased finger joints. The versatility of these materials has led to silicone products being employed in almost every medical speciality.

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Silicones as Artificial Internal Tissue and Organ Substitutes

Abstract: Silastic is the trademark of Dow Corning Corp. for its silicone rubber.

Cited by 5 publications

References 26 publications

Plasma Polymer Coatings to Support Mesenchymal Stem Cell Adhesion, Growth and Differentiation on Variable Stiffness Silicone Elastomers

Plasma Polymer Coatings to Support Mesenchymal Stem Cell Adhesion, Growth and Differentiation on Variable Stiffness Silicone Elastomers

Prosthetic urinary bladder implantation to facilitate bladder regeneration

Silicones as biomaterials

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