Silk-Based Composite Scaffolds for Tissue Engineering Applications

Tandon, Saloni; Kandasubramanian, Balasubramanian; Ibrahim, Sobhy M.

doi:10.1021/acs.iecr.0c02195

Cited by 69 publications

(26 citation statements)

References 171 publications

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“…Several scientists have tested composite silk scaffolding to achieve the necessary characteristics by changing the blended materials, the silk-producing source, or the material concentration in that composite, and it was proven very suitable for the TE. [ 64 ]. The versatility of silk fibroin can be seen in its various applications, from silk as a bulk part to silk as a coating or reinforcement of non-cytocompatible scaffolds.…”

Section: Polymers As Biomaterials For Scaffoldingmentioning

confidence: 99%

A Comparative Review of Natural and Synthetic Biopolymer Composite Scaffolds

et al. 2021

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Tissue engineering (TE) and regenerative medicine integrate information and technology from various fields to restore/replace tissues and damaged organs for medical treatments. To achieve this, scaffolds act as delivery vectors or as cellular systems for drugs and cells; thereby, cellular material is able to colonize host cells sufficiently to meet up the requirements of regeneration and repair. This process is multi-stage and requires the development of various components to create the desired neo-tissue or organ. In several current TE strategies, biomaterials are essential components. While several polymers are established for their use as biomaterials, careful consideration of the cellular environment and interactions needed is required in selecting a polymer for a given application. Depending on this, scaffold materials can be of natural or synthetic origin, degradable or nondegradable. In this review, an overview of various natural and synthetic polymers and their possible composite scaffolds with their physicochemical properties including biocompatibility, biodegradability, morphology, mechanical strength, pore size, and porosity are discussed. The scaffolds fabrication techniques and a few commercially available biopolymers are also tabulated.

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Section: Polymers As Biomaterials For Scaffoldingmentioning

confidence: 99%

A Comparative Review of Natural and Synthetic Biopolymer Composite Scaffolds

et al. 2021

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“…The latter are materials retrieved from plant tissue in the perspectives of developing human tissue structures compatible for 3D culture of mammalian cells [ 33 ]. Nanocellulose-based scaffolds, in particular nanocrystalline cellulose and nanofibrillated cellulose [ 34 ], and silk-based composite scaffolds [ 35 ] have proven their potential in regenerative medicine such as wound healing and organ reparation, due to their special permeability and hemocompatibility.…”

Section: Three-dimensional Culture Systemsmentioning

confidence: 99%

Biomaterials for Three-Dimensional Cell Culture: From Applications in Oncology to Nanotechnology

et al. 2021

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Three-dimensional cell culture has revolutionized cellular biology research and opened the door to novel discoveries in terms of cellular behavior and response to microenvironment stimuli. Different types of 3D culture exist today, including hydrogel scaffold-based models, which possess a complex structure mimicking the extracellular matrix. These hydrogels can be made of polymers (natural or synthetic) or low-molecular weight gelators that, via the supramolecular assembly of molecules, allow the production of a reproducible hydrogel with tunable mechanical properties. When cancer cells are grown in this type of hydrogel, they develop into multicellular tumor spheroids (MCTS). Three-dimensional (3D) cancer culture combined with a complex microenvironment that consists of a platform to study tumor development and also to assess the toxicity of physico-chemical entities such as ions, molecules or particles. With the emergence of nanoparticles of different origins and natures, implementing a reproducible in vitro model that consists of a bio-indicator for nano-toxicity assays is inevitable. However, the maneuver process of such a bio-indicator requires the implementation of a repeatable system that undergoes an exhaustive follow-up. Hence, the biggest challenge in this matter is the reproducibility of the MCTS and the associated full-scale characterization of this system’s components.

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“…They also model the growth of hydroxyapatite facilitating the osseointegration process [54]. Silk 3-D porous scaffolds require other manufacturing techniques [55]. The silk fibroin concentration represents a decisive element for final porosity formation and mechanical properties.…”

Section: Hydrogelmentioning

confidence: 99%

The Silk, Versatile Material for Biological, Optical, and Electronic Fields: Review

Bibbò¹,

Khan²,

Tareen³

2021

GJRE

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Silk, seen as a material, is a fiber made from silkworm cocoons and spiders. They have standard structural components and hierarchical structures. Different manufacturing techniques allow obtaining silk in films, fibers, hydrogels, microspheres, and sponges. We can tune the properties through the structure of secondary proteins. The paper explores the application in biomedical, optics, and electronic fields by analyzing the technological trend.

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Silk-Based Composite Scaffolds for Tissue Engineering Applications

Cited by 69 publications

References 171 publications

A Comparative Review of Natural and Synthetic Biopolymer Composite Scaffolds

A Comparative Review of Natural and Synthetic Biopolymer Composite Scaffolds

Biomaterials for Three-Dimensional Cell Culture: From Applications in Oncology to Nanotechnology

The Silk, Versatile Material for Biological, Optical, and Electronic Fields: Review

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