Silver diamine fluoride remineralized artificial incipient caries in permanent teeth after bacterial pH-cycling in-vitro

Punyanirun, Kulnipa; Yospiboonwong, Thanida; Kunapinun, Thansinee; Thanyasrisung, Panida; Trairatvorakul, Chutima

doi:10.1016/j.jdent.2017.09.005

Cited by 37 publications

(28 citation statements)

References 28 publications

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“…The discovery of the anti-caries effect of fluoride opened up a new field in the control of caries. Fluoride can form a reservoir of calcium fluoride or can be taken in and develop fluorhydroxyapatite (HA), which can re-mineralize early enamel caries [1,4,19–21]. The crystal layer of HA can make the enamel more stable and difficult to dissolved [22].…”

Section: Discussionmentioning

confidence: 99%

Awareness of the Benefits and Risks Related to Using Fluoridated Toothpaste Among Doctors: A Population-Based Study

2019

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Background This study aimed to assess the awareness of dentists and non-dental doctors regarding the benefits and risks of using fluoridated toothpaste. Material/Methods A self-administered questionnaire was used to collect information in this study. Multistage cluster sampling method was used to enroll doctors in 5 districts or counties in Chongqing, China. A total of 403 doctors (160 dentists and 243 non-dental doctors) completed the questionnaire. Results The awareness of the anti-caries efficacy and the usage of fluoridated toothpaste in dentists was significantly higher than those of non-dental doctors (P<0.001). Most (about 60%) dentists and non-dental doctors had concerns about fluoridated toothpaste. Only 31.3% of dentists and 25.9% of non-dental doctors had a good understanding of the benefits and risks of use of fluoridated toothpaste in children under 3 years of age to 49.4% of dentists and 73.3% of non-dental doctors did not understand the benefits and risks in children 3~6 years old, and 40.0% of dentists and 67.5% of non-dental doctors did not understand the risks and benefits in individuals living in high-fluoride areas. Most dentists (76.3%) and non-dental doctors (87.3%) did not understand the benefits and risks in pregnant women. Conclusions Dentists and non-dental doctors were concerned about the potential risks of use of fluoridated toothpaste, and they lacked adequate knowledge about the benefits and risks of use of fluoridated toothpaste. Health education is needed to improve doctors’ knowledge about use of fluoridated toothpaste.

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Section: Discussionmentioning

confidence: 99%

Awareness of the Benefits and Risks Related to Using Fluoridated Toothpaste Among Doctors: A Population-Based Study

2019

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“…Phosphate ions also participated in fluorapatite formation. High concentration of calcium, fluoride, and phosphate ions after SDF treatment might contribute in deep remineralization of carious lesions [43]. The synergistic effect of silver and fluoride ions in the inhibition of cariogenic biofilm growth, remineralization, and protection of organic matrix is the reason for SDF effectiveness to arrest the pre-exiting dentin caries and preventing new caries formation.…”

Section: Plos Onementioning

confidence: 99%

Effect of silver diamine fluoride and proanthocyanidin on resistance of carious dentin to acid challenges

et al. 2020

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The aim of this study was to evaluate the effect of silver diamine fluoride and grape seed extract on the microstructure and mechanical properties of carious dentin following exposure to acidic challenge. Ninety-eight molars with occlusal caries were used. In the control group the specimens were kept in distilled water. In the GSE group, the specimens were immersed in 6.5% grape seed extract solution for 30 minutes. In the SDF group, the specimens were immersed in 30% SDF solution for 4 minutes. In the GSE+SDF group, the specimens were immersed in 6.5% grape seed extract solution for 30 minutes and then exposed to 30% SDF solution for 4 minutes. All the groups underwent pH cycling model for 8 days. Microhardness measurements were taken at the baseline before surface treatments and after pH cycling. Elastic modulus was measured, after pH cycling. In the control group, the final hardness was significantly lower than the initial hardness (P = 0.001). In the SDF group, the final hardness was significantly higher than the initial hardness (P < 0.001). There was no significant difference between the initial and final hardness values in the GSE and GSE + SDF groups (p = 0.92, p = 0.07). The H 1-H 0 in the SDF group was significantly higher than the other groups (P<0.05). Moreover, elastic modulus of the experimental groups except GSE+SDF group was significantly higher than control. The highest mean elastic modulus was detected in the SDF group (P<0.001). The use of SDF and GSE prior to the acid challenge improved mechanical properties. Microstructural investigation, using scanning electron microscope showed dentin structure protection against acid challenges with SDF treatment and collagen matrix stabilization with GSE treatment. However combined use of these agents was not beneficious.

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“…To the best of our knowledge, there are no studies on the effect of fTCP and fluoride on the mineral changes in enamel subsurface lesions. Some non-destructive techniques allow the long-term evaluation of the effects of remineralizing agents on the enamel and dentin [27][28][29][30]. Micro-focus X-ray computed tomography (μCT) is useful for evaluating the mineral density (MD) and mineral structure of bones, teeth, and similar tissues without causing tissue destruction [4,31,32].…”

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confidence: 99%

Remineralization of enamel subsurface lesions using toothpaste containing tricalcium phosphate and fluoride: an in vitro µCT analysis

et al. 2020

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Background This study aimed to compare the efficacies of experimental toothpastes containing functionalized tricalcium phosphate (fTCP) with and without fluoride for in vitro enamel remineralization under pH-cycling conditions. Methods To create artificial white spot lesions, 36 bovine enamel specimens were immersed in a demineralization solution for 10 days. During pH-cycling for 12 days, the specimens were divided into four groups based on the experimental toothpaste type used: (a) fTCP-free, fluoride-free (fTCP − F −); (b) fTCP-containing, fluoride-free (fTCP + F −); (c) fTCP-free, fluoride-containing (fTCP − F +); and (d) fTCP-containing, fluoride-containing (fTCP + F +). Micro-focus X-ray computed tomography (μCT) scans of all specimens were obtained before demineralization, after demineralization, and after pH-cycling. The mineral density and mineral loss (ΔZ) in the enamel subsurface lesions were measured and the percentage of remineralization (%R) was calculated from ΔZ after demineralization and pH-cycling. One-way ANOVA with Tukey’s test was used for statistical analysis of the %R values. The treated enamel surface was investigated via scanning electron microscopy (SEM). Results The fTCP − F − group presented with the lowest amount of mineral gain after pH-cycling. In contrast, the fTCP + F + group showed the highest degree of remineralization within all lesion parts. The %R was highest in the fTCP + F + group (38.2 ± 7.8, all P < 0.01). SEM revealed the presence of small crystals on the enamel rods in the fTCP + F − and fTCP + F + groups. Conclusions The experimental toothpaste containing fTCP and fluoride increased remineralization of the artificial enamel subsurface lesions during pH-cycling. Furthermore, fTCP and fluoride appear to act independently on the remineralization of enamel subsurface lesions, although they coexisted in one toothpaste type. Trial registration: This is not a human subject research.

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Silver diamine fluoride remineralized artificial incipient caries in permanent teeth after bacterial pH-cycling in-vitro

Cited by 37 publications

References 28 publications

Awareness of the Benefits and Risks Related to Using Fluoridated Toothpaste Among Doctors: A Population-Based Study

Awareness of the Benefits and Risks Related to Using Fluoridated Toothpaste Among Doctors: A Population-Based Study

Effect of silver diamine fluoride and proanthocyanidin on resistance of carious dentin to acid challenges

Remineralization of enamel subsurface lesions using toothpaste containing tricalcium phosphate and fluoride: an in vitro µCT analysis

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