Silver-incorporating peptide and protein supramolecular nanomaterials for biomedical applications

Abstract

The natural biomolecules of peptides and proteins are able to form elegant metal incorporating supramolecular nanomaterials through multiple weak non-covalent interactions.

Amyloid‐β Inspired Short Peptide Amphiphile Facilitates Synthesis of Silver Nanoparticles as Potential Antibacterial Agents

“…Therefore a unique electronic feature coming from used metal/metal nanoparticles, aromatic, amide, carboxylic group, and fatty acid chain are important factors to stabilize these structures. The biologically relevant Ag(I) ion and AgNPs loaded sPA1 nanosystems will lead to emulsification of sPA1 hybrids and therefore possess a great advantage in the drug‐delivery fields [53–54] . Such hybrid nanosystems can potentially act as cargo for the targeted release of the encapsulated bioactive nanoparticles via controlling the internal nanostructures upon phase changes that can induce the loaded active component.…”

“…Thus, the above results indicate that the MIC of AgNPs‐sPA hybrids nanosystems strongly impacts their efficacy and therefore can be used as an alternative approach. As it is based on available literature reports; the two mechanisms of antibacterial activity of silver nanoparticle embedded peptide nanofibers leading to bacterial death are reactive oxygen species(ROS) [53] and high drug (AgNPs) payload capacity, which create oxidative stress and enhanced hydrophobic interactions caused disruption of bacterial cell membrane [56] . In addition, such methods can also be useful against multidrug‐resistant (MDR) bacteria and therefore can be considered as targeted and controlled facile drug delivery agents.…”

Synthesis and Organization of Gold-Peptide Nanoparticles for Catalytic Activities

“…Recently, metal, especially gold and silver, composites with peptides and proteins where they act as stabilizing and reducing agents have been developed. 3,4 The applications of gold nanoparticles depend on their size, shape, and composition as well as their arrangement and self-organization. 5,6 However, the preparation of gold nanoparticles with defined dimensions and controlled size and morphology and their random aggregation and compromised biocompatibility have remained to be significant challenges.…”

Skin-like wound dressings with on-demand administration based onin situpeptide self-assembly for skin regeneration

“…[1][2][3] Wound management has been an important problem worldwide, and more and more attention has been paid to wound dressings. [4][5][6] At present, many antibacterial materials have been widely used as wound dressings, [7][8][9] such as antibiotics, 10 inorganic antibacterial materials, 11,12 cationic polymers, etc. However, there is still an urgent need for novel wound dressings, due to the antibiotic resistance and poor biological safety of inorganic and polymeric materials.…”