Silver nanoparticles: Toxicity in model organisms as an overview of its hazard for human health and the environment

Tortella, Gonzalo; Rubilar, Olga; Durán, Nelsón; Díez, M.C.; Martı́nez, Miguel Ángel; Parada, J.; Seabra, Amedea B.

doi:10.1016/j.jhazmat.2019.121974

Cited by 356 publications

(177 citation statements)

References 194 publications

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“…However, based on such data, despite the high removal efficiency, the authors estimated a total release in the environment of 33 Kg AgNPs/year for the whole country [126]. For these reasons, AgNPs have stimulated considerable attention in terms of potential environmental risks consequent to their production, usage, disposal and application [127][128][129][130].…”

Section: Environmental Safety Of Enmsmentioning

confidence: 99%

Silver Nanoparticles for Water Pollution Monitoring and Treatments: Ecosafety Challenge and Cellulose-Based Hybrids Solution

et al. 2020

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Silver nanoparticles (AgNPs) are widely used as engineered nanomaterials (ENMs) in many advanced nanotechnologies, due to their versatile, easy and cheap preparations combined with peculiar chemical-physical properties. Their increased production and integration in environmental applications including water treatment raise concerns for their impact on humans and the environment. An eco-design strategy that makes it possible to combine the best material performances with no risk for the natural ecosystems and living beings has been recently proposed. This review envisages potential hybrid solutions of AgNPs for water pollution monitoring and remediation to satisfy their successful, environmentally safe (ecosafe) application. Being extremely efficient in pollutants sensing and degradation, their ecosafe application can be achieved in combination with polymeric-based materials, especially with cellulose, by following an eco-design approach. In fact, (AgNPs)–cellulose hybrids have the double advantage of being easily produced using recycled material, with low costs and possible reuse, and of being ecosafe, if properly designed. An updated view of the use and prospects of these advanced hybrids AgNP-based materials is provided, which will surely speed their environmental application with consequent significant economic and environmental impact.

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Section: Environmental Safety Of Enmsmentioning

confidence: 99%

Silver Nanoparticles for Water Pollution Monitoring and Treatments: Ecosafety Challenge and Cellulose-Based Hybrids Solution

et al. 2020

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“…MNPs have unique physical properties, high surface-area-to-volume ratio, and are clearly distinguished from bulk metals due to their reactivity, as well as their mechanical, electromagnetic, chemical, and optical properties, which are conferred by the confinement effect [3][4][5]. MNPs often display surface Plasmon resonance, which leads to absorption in the UV-Vis region and distinct optoelectronic characteristics, which facilitates their detection.…”

Section: Metal Nanoparticles (Mnps)mentioning

confidence: 99%

“…With the increased development of nanotechnology and its research, many applications of MNPs have already been implemented ( Figure 1) and more developments are expected [4]. [2,4,5,7]).…”

Section: Metal Nanoparticles (Mnps)mentioning

confidence: 99%

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Biogenic Metal Nanoparticles: A New Approach to Detect Life on Mars?

Simões

Ottoni

Antunes

2020

Life

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Metal nanoparticles (MNPs) have been extensively studied. They can be produced via different methods (physical, chemical, or biogenic), but biogenic synthesis has become more relevant, mainly for being referred by many as eco-friendly and more advantageous than others. Biogenic MNPs have been largely used in a wide variety of applications, from industry, to agriculture, to health sectors, among others. Even though they are increasingly researched and used, there is still space for exploring further applications and increasing their functionality and our understanding of their synthesis process. Here, we provide an overview of MNPs and biogenic MNPs, and we analyze the potential application of their formation process to astrobiology and the detection of life on Mars and other worlds. According to current knowledge, we suggest that they can be used as potential biosignatures in extra-terrestrial samples. We present the advantages and disadvantages of this approach, suggest further research, and propose its potential use for the search for life in future space exploration.

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“…Nanomaterials, typically 0.2–100 nm, have a high surface-to-volume ratio and their physicochemical properties differ from those of larger sizes because the reduced size confers a greater surface area; this allows an increase in chemical reactivity, greater penetration power, and faster effects [ 18 ]. Within all existing possibilities, silver nanoparticles (AgNPs), with almost a quarter of the total nanomaterials being marketed, are the most widely used nanomaterial [ 19 ], due to their remarkable antimicrobial properties (bactericidal, fungicidal, and antiviral) [ 20 , 21 ]. The mechanisms of action by which AgNPs exert their antimicrobial activity are not clear, but two main hypotheses have been proposed, direct interaction with the cell membrane and the release of ionic silver [ 20 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Glutathione-Stabilized Silver Nanoparticles: Antibacterial Activity against Periodontal Bacteria, and Cytotoxicity and Inflammatory Response in Oral Cells

et al. 2020

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Silver nanoparticles (AgNPs) have been proposed as new alternatives to limit bacterial dental plaque because of their antimicrobial activity. Novel glutathione-stabilized silver nanoparticles (GSH-AgNPs) have proven powerful antibacterial properties in food manufacturing processes. Therefore, this study aimed to evaluate the potentiality of GSH-AgNPs for the prevention/treatment of oral infectious diseases. First, the antimicrobial activity of GSH-AgNPs against three oral pathogens (Porphyromonas gingivalis, Fusobacterium nucleatum, and Streptococcus mutans) was evaluated. Results demonstrated the efficiency of GSH-AgNPs in inhibiting the growth of all bacteria, especially S. mutans (IC50 = 23.64 μg/mL, Ag concentration). Second, GSH-AgNPs were assayed for their cytotoxicity (i.e., cell viability) toward a human gingival fibroblast cell line (HGF-1), as an oral epithelial model. Results indicated no toxic effects of GSH-AgNPs at low concentrations (≤6.16 µg/mL, Ag concentration). Higher concentrations resulted in losing cell viability, which followed the Ag accumulation in cells. Finally, the inflammatory response in the HGF-1 cells after their exposure to GSH-AgNPs was measured as the production of immune markers (interleukins 6 and 8 (IL-6 and IL-8) and tumor necrosis factor-alpha (TNF-α)). GSH-AgNPs activates the inflammatory response in human gingival fibroblasts, increasing the production of cytokines. These findings provide new insights for the use of GSH-AgNPs in dental care and encourage further studies for their application.

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Silver nanoparticles: Toxicity in model organisms as an overview of its hazard for human health and the environment

Cited by 356 publications

References 194 publications

Silver Nanoparticles for Water Pollution Monitoring and Treatments: Ecosafety Challenge and Cellulose-Based Hybrids Solution

Silver Nanoparticles for Water Pollution Monitoring and Treatments: Ecosafety Challenge and Cellulose-Based Hybrids Solution

Biogenic Metal Nanoparticles: A New Approach to Detect Life on Mars?

Glutathione-Stabilized Silver Nanoparticles: Antibacterial Activity against Periodontal Bacteria, and Cytotoxicity and Inflammatory Response in Oral Cells

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