Silver sulfadiazine loaded chitosan/chondroitin sulfate films for a potential wound dressing application

Fajardo, André R.; Lopes, Laís C.; Caleare, Angelo O.; Britta, Elizandra Aparecida; Nakamura, Celso Vataru; Rubira, Adley F.; Muniz, Edvani C.

doi:10.1016/j.msec.2012.09.025

Cited by 93 publications

(52 citation statements)

References 35 publications

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“…E. coli, as a Gram-negative bacterium, has a thick layer of lipopolysaccharide outer membrane covering the cell wall, which lead more resistant to hydrophobic substance (Zhang, Liu, Wang, Jiang, & Quek, 2016). The results reported in this study are consistent with other works on bactericidal action of AgSD (Fajardo et al, 2013). Furthermore, BC/SA-AgSD composites also exhibited good antifungal behavior against C. albicans.…”

Section: Antibacterial and Antifungal Activitiessupporting

confidence: 91%

“…2), the peak intensities of AgSD increased with the increase of AgSD loadings in the composites. And the samples with higher loadings of AgSD showed a more significant shoulder at 3391 cm −1 due to the free N H (Fajardo et al, 2013). Moreover, hydrogen bonding formed between amine group from AgSD and carbonyl and hydroxyl groups from BC/SA, which could promote NH 2 stretching bands to shift to minor wavenumber.…”

Section: Ftir Spectroscopymentioning

confidence: 97%

“…Three strains including Gram-negative E. coli ATCC 25922, Gram-positive S. aureus ATCC 6538 and Yeast C. albicans CMCC(F) 98001 were selected for antibacterial tested because they are usually associated with the infections during wound healing procedure (Fajardo et al, 2013;Jo, Jung, Choi, & Lee, 2012).…”

Section: Antibacterial and Antifungal Activitiesmentioning

confidence: 99%

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Development of silver sulfadiazine loaded bacterial cellulose/sodium alginate composite films with enhanced antibacterial property

Shao

Liu

et al. 2015

Carbohydrate Polymers

150

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Section: Antibacterial and Antifungal Activitiessupporting

confidence: 91%

Section: Ftir Spectroscopymentioning

confidence: 97%

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Development of silver sulfadiazine loaded bacterial cellulose/sodium alginate composite films with enhanced antibacterial property

Shao

Liu

et al. 2015

Carbohydrate Polymers

150

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“…[10][11][12][13][14] Moreover, biocompatible polymer wound dressing materials (semipermeable lms, foams, hydrogels, hydrocolloids and xerogels) are intensively investigated in order to accelerate wound healing by preventing both uid loss and bacterial infection by controlled antibacterial release. [15][16][17][18][19][20] In recent years, nanoporous silica-based drug delivery systems have also been developed. 21,22 Nanoporous silica carriers (SBA-15 or MCM-41) are biocompatible materials, and they have the capability to load nanosized metal particles into the channels and can be functionalized with organic groups.…”

Section: Nanosuspensionsmentioning

confidence: 99%

Silver- and sulfadiazine-loaded nanostructured silica materials as potential replacement of silver sulfadiazine

et al. 2014

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Silver sulfadiazine (AgSD) is the leading topical antibacterial agent for the treatment of burn wound infections. Antibacterial effect of AgSD is limited by its poor aqueous solubility, and antibacterial activity develops only by decomposition of AgSD to silver ions and sulfadiazine. In this study, it is for the first time that application of silver-modified nanoporous silica carriers (MCM-41 or SBA-15) loaded with sulfadiazine (SD), instead of silver sulfadiazine, overcoming the abovementioned disadvantages has been demonstrated. By direct or post synthesis methods, 5-15 nm sized silver nanoparticles can be stabilized in the channels or on the outer surface of nanoporous silica supports; moreover, the empty channels can be loaded by SD molecules. The SD-loaded, silver-modified materials show sustained release properties and similar or even better antimicrobial properties than AgSD. Adsorption of AgSD on nanoporous silica particles significantly improves its water solubility.

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“…No entanto, as desvantagens em seus usos incluem manchas na pele e toxicidade, além de necessitar frequente remoção e reaplicação da sulfadiazina de prata, ocasionando pseudo-cicatrizes, dor e trauma no paciente queimado [1] . Nesta perspectiva, uma alternativa é a utilização de curativos à base de filmes de biopolímeros, como, por exemplo, a quitosana.…”

Section: Introductionunclassified

Desenvolvimento e caracterização de filmes compósitos de quitosana e zeólitas com prata

et al. 2015

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ResumoZeólitas foram submetidas à troca iônica ou impregnação com prata e posteriormente adicionadas em filmes de quitosana para a confecção de curativos para queimaduras. As zeólitas foram avaliadas por Ressonância magnética nuclear (RMN), Fluorescência de raios X por reflexão total (TXRF), Microscopia eletrônica de varredura (MEV). Os filmes poliméricos foram analisados com relação às suas propriedades mecânicas, permeabilidade ao vapor d'água (PVA) e liberação de prata. Observou-se que o procedimento de troca iônica não alterou a morfologia das zeólitas de partida. Grumos de zeólita foram observados nas micrografias dos filmes e estes influenciaram nas propriedades mecânicas devido à desorganizaçao local no empacotamento das cadeiras poliméricas da quitosana. A metodologia de troca iônica ou impregnação influenciou diretamente na quantidade de prata presente superficialmente na zeólita e consequentemente alterou o perfil de liberação de prata em uma solução simulada de exudato de ferida. Os modelos cinéticos sugeriram que a liberação da prata não foi essencialmente regulada pela lei de difusão de Fick. Palavras-chave: impregnação, troca-iônica, curativos para queimados, zeólita Y. AbstractZeolites were subjected to ion exchange or impregnation with silver and added to chitosan films for producing burns dressings. Zeolites were characterized by nuclear magnetic resonance (NMR), total reflection X-ray fluorescence (TXRF), scanning electron microscopy (SEM). The polymer films were analyzed with respect to their mechanical properties, water vapor permeability (WVP), and release of silver. It was observed that the ion exchange did not modify the morphology of the starting zeolite. Clusters of zeolite were observed in the micrographs of the films and they influenced the mechanical properties due to local disruption in the packing of the polymer chains of chitosan. The methodology of ion exchange or impregnation directly influenced the amount of silver present in the zeolite surface and consequently changed the silver release profile in an of simulated exudate fluid. The kinetic models suggested that the release of the silver was not primarily governed by Fick's law of diffusion.

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Silver sulfadiazine loaded chitosan/chondroitin sulfate films for a potential wound dressing application

Cited by 93 publications

References 35 publications

Development of silver sulfadiazine loaded bacterial cellulose/sodium alginate composite films with enhanced antibacterial property

Development of silver sulfadiazine loaded bacterial cellulose/sodium alginate composite films with enhanced antibacterial property

Silver- and sulfadiazine-loaded nanostructured silica materials as potential replacement of silver sulfadiazine

Desenvolvimento e caracterização de filmes compósitos de quitosana e zeólitas com prata

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