Similar effects of tryptophan and sleep on cisternal cerebrospinal fluid 5-hydroxyindoleacetic and homovanillic acids in cats

Radulovački, Miodrag; Rl, Buckingham; Eh, Chen; R, Kovacević

doi:10.1016/0006-8993(77)90018-x

Cited by 13 publications

(1 citation statement)

References 10 publications

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“…Neurochemical experiments have demonstrated that IPA administered accurately at doses of 20-50 mg kg-'i.p. increases 5-HT and 5hydroxyindoleacetic acid (FHIAA) concentrations in various brain areas of the rat (Bacciottini et al 1987) and 5-HIAA levels in the cerebrospinal fluid (Ruggeri et al 1990), as does tryptophan (Radulovacki et al 1977, Wojcik et a/. 1980.…”

Section: Discussionmentioning

confidence: 99%

Effects of indole‐pyruvic acid on sleep and food intake in the rat

Pich¹,

Solfrini²,

Biagini³

et al. 1990

Acta Physiologica Scandinavica

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Indole-pyruvic acid was studied for its short- and long-term effects on electroencephalographic sleep and on food intake in rats implanted with cortical and muscular electrodes. Following a single injection, indole-pyruvic acid (10-50 mg kg-1 i.p.) reduced by 16-23 min (range) the latency of the first slow-wave episode in a dose-related fashion and produced a significant increase in slow-wave sleep time (12-40%) in doses of 10-30 mg kg-1. Rapid eye movement sleep latency and rapid eye movement sleep time were increased (by 23-37 min) and reduced (57-71%) respectively. The effects of indole-pyruvic acid on slow-wave sleep time were still present after 3, 7 and 14 days of chronic administration (10 mg kg-1 day-1), whereas tolerance to the effect of indole-pyruvic acid on rapid eye movement sleep was observed. Daily food consumption was reduced (20-28%) by acute administration of indole-pyruvic acid (15-30 mg kg-1 i.p.), but tolerance developed after 5 days of repeated injections. These findings are in accordance with previous evidence suggesting that indole-pyruvic acid effects may be related to the activation of central serotonin neurons, which are involved in the inhibitory control of sleep and food intake.

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Section: Discussionmentioning

confidence: 99%