Similar Impact of Clopidogrel or Ticagrelor on Carotid Atherosclerotic Plaque Inflammation

Oh, Minyoung; Lee, Cheol Whan; Lee, Hyo Sang; Chang, Mineok; Ahn, Jung‐Min; Park, Duk‐Woo; Kang, Soo–Jin; Lee, Seung-Whan; Kim, Young‐Hak; Moon, Dae Hyuk; Park, Seong-Wook; Park, Seung‐Jung

doi:10.1002/clc.22575

Cited by 15 publications

(6 citation statements)

References 39 publications

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“…T is a new P2Y12 receptor inhibitor that is reported to have a more potent antiplatelet property than clopidogrel [15]. Prior reports have suggested that T not only inhibits the systemic inflammatory response, but also has a therapeutic effect on the local inflammatory response of atherosclerotic plaque [31,32]. Interestingly, both pathological alterations and risk factors associated with AAA are comparable to that of atherosclerosis.…”

Section: Discussionmentioning

confidence: 99%

Combinational Therapy with Aspirin and Ticagrelor Alleviates Vascular Inflammation and Angiotensin IIdriven Abdominal Aortic Aneurysm Formation in Mice

X-W¹,

Y-Z²,

J-G³

et al. 2022

austinjcardiovascdisatherosclerosis

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Background: Abdominal aortic aneurysm (AAA) is a severe form of blood vessel-related disease. Medial degeneration and inflammation are typical characteristic of AAA. Activated platelets release many pro-inflammatory cytokines and participate in the initial inflammatory response to various vascular diseases. Although there are some studies on the effects of APAs on AAA, it is yet unknown whether the new P2Y12 receptor inhibitor ticagrelor (T) can inhibit AAA. Herein, we explored the consequences of ticagrelor exposure on AAA progression and determined whether a combinational therapy, involving T and aspirin (A), exerts a stronger inhibitory effect in vivo. Methods: AAA was established in apolipoprotein E-deficient (ApoE-/- ) mice via a 28-day administration of angiotensin II (Ang II). Next, the mice were arbitrarily separated into 5 groups: saline infusion alone (sham), Ang II infusion alone, Ang II infusion plus oral A (10 mg•kg-1•d-1), Ang II infusion plus oral T (120 mg.kg-1.d-1), Ang II infusion plus combinational therapy with A (10 mg•kg-1•d-1) and T (120 mg.kg-1.d-1). Results: The combined treatment markedly suppressed the Ang II-driven elevation of maximal aortic diameter, aneurysm formation (26.7% decrease, P<0.05), alterations in aortic expansion, elastic lamina destruction, platelet deposition, and inflammatory cytokine accumulation. In addition, it also diminished matrix metalloproteinase (MMP)-2 and MMP-9 production. Conclusions: A combinational therapy of A and T, but not individual drugs, inhibits Ang II-driven AAA generation in mice in vivo, and this process may be regulated by a suppressed inflammatory response.

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Section: Discussionmentioning

confidence: 99%

Combinational Therapy with Aspirin and Ticagrelor Alleviates Vascular Inflammation and Angiotensin IIdriven Abdominal Aortic Aneurysm Formation in Mice

X-W¹,

Y-Z²,

J-G³

et al. 2022

austinjcardiovascdisatherosclerosis

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“…22 As stated in the study of Oh et al, the 6-month treatment of clopidogrel or ticagrelor obviously decreased carotid atherosclerotic plaque inflammation. 23 ZHANG et al…”

Section: Discussionmentioning

confidence: 99%

Comparison of the effect of ticagrelor combined with tirofiban versus clopidogrel combined with tirofiban on inflammation response and prognosis of patients with unstable angina pectoris in long term follow‐up

Deng

Jia

et al. 2021

The Kaohsiung J of Med Scie

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To investigate the effect of ticagrelor combined with tirofiban versus clopidogrel combined with tirofiban on inflammation response and prognosis of patients with unstable angina pectoris (UA). The present prospective study included a total of 291 patients who were diagnosed as unstable UA from January 2018 to December 2019. All UA patients were divided into two groups: ticagrelor combined with tirofiban group (n = 159) and clopidogrel combined with tirofiban group (n = 132). Serum levels of C-reactive protein (CRP), interleukin-1β, interleukin-6, tumor necrosis factor-α, and matrix metalloproteinase-9 were measured using commercially available enzyme-linked immunosorbent assay kits. Kaplan-Meier (K-M) curve was performed for analysis of cumulative incidences of major adverse cardiovascular events (MACEs). Both ticagrelor combined with tirofiban and clopidogrel combined with tirofiban significantly decreased the serum levels of inflammatory factors in UA patients. Compared to clopidogrel combined with the tirofiban group, ticagrelor combined with the tirofiban group had a lower platelet aggregation rate and improved cardiac function of UA patients. Besides, ticagrelor combined with tirofiban group had a better prognosis and the K-M curve showed that UA patients treated by ticagrelor and tirofiban had lower incidences of MACEs in one-year follow-up. The treatment of ticagrelor combined with tirofiban significantly attenuated inflammation response and improved the prognosis of UA patients.

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“…Platelet aggregation, smooth muscle cell proliferation and migration, and extracellular matrix changes are major factors for neointimal hyperplasia [28,29]. Although several studies have demonstrated that P2Y12 antagonists were linked to inhibition of plaque inflammation and smooth muscle cell proliferation, reducing intimal hyperplasia [30,31], there are few data supporting an association between DAPT duration and differences in intra-stent healing related to second-generation DESs. In this study, neointimal proliferation for R-ZESs was greater in patients with short-duration DAPT.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the 9-month intra-stent conditions and 2-year clinical outcomes after Resolute zotarolimus-eluting stent implantation between 3-month and standard dual antiplatelet therapy

Fujimoto

Sawada

Toba

et al. 2018

Journal of Cardiology

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Similar Impact of Clopidogrel or Ticagrelor on Carotid Atherosclerotic Plaque Inflammation

Abstract: Background:Platelets play an important role in inflammation. Inhibitors of the P2Y 12 receptor,

Cited by 15 publications

References 39 publications

Combinational Therapy with Aspirin and Ticagrelor Alleviates Vascular Inflammation and Angiotensin IIdriven Abdominal Aortic Aneurysm Formation in Mice

Combinational Therapy with Aspirin and Ticagrelor Alleviates Vascular Inflammation and Angiotensin IIdriven Abdominal Aortic Aneurysm Formation in Mice

Comparison of the effect of ticagrelor combined with tirofiban versus clopidogrel combined with tirofiban on inflammation response and prognosis of patients with unstable angina pectoris in long term follow‐up

Comparison of the 9-month intra-stent conditions and 2-year clinical outcomes after Resolute zotarolimus-eluting stent implantation between 3-month and standard dual antiplatelet therapy

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