Simulating Outcomes of Cataract Surgery: Important Advances in Ophthalmology

Marcos, Susana; Martinez-Enriquez, Eduardo; Viñas, María; Castro, Alberto de; Dorronsoro, Carlos; Bang, Seung Pil; Yoon, Geunyoung; Artal, Pablo

doi:10.1146/annurev-bioeng-082420-035827

Cited by 27 publications

(14 citation statements)

References 148 publications

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“…24 Vision simulators based on temporal multiplexing were advantageous over AO-based simulators regarding prices and sizes. 25 Although various vision simulators were developed for in vivo testing in patients, these devices need more time to be accessible. In vitro testing in optical bench systems avoids the aforementioned subjective factors, can objectively and accurately evaluate the optical performance of the IOL, and can provide guidelines for selecting appropriate IOLs based on the aberration conditions of patients.…”

Section: Discussionmentioning

confidence: 99%

In vitro optical performance of multifocal and extended depth-of-focus intraocular lenses in spherical aberration conditions

Park

Kim²,

Kim³

2022

J Cataract Refract Surg

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Section: Discussionmentioning

confidence: 99%

In vitro optical performance of multifocal and extended depth-of-focus intraocular lenses in spherical aberration conditions

Park

Kim²,

Kim³

2022

J Cataract Refract Surg

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“…The crystalline lens loses its accommodation ability and transparency with age, in what is known as presbyopia and cataract, respectively. The most common treatment for cataract involves removing the opacified crystalline lens and replacing it with an artificial intraocular lens (IOL) [2]. Emergent treatments for presbyopia, still under development, include accommodative IOLs (A-IOLs) [3,4], which attempt to mimic the ability of the natural crystalline lens to change its shape (and thus its optical power) as a response of the action of the ciliary muscle, or pharmacological treatments to soften the crystalline lens material [5].…”

Section: Introductionmentioning

confidence: 99%

Estimation of the full shape of the crystalline lens from OCT: validation using stretched donor lenses

Martinez-Enriquez¹,

Heilman²,

Castro³

et al. 2023

Preprint

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Quantifying human crystalline lens geometry as a function of age and accommodation is important for improved cataract and presbyopia treatments. In previous works we presented eigenlenses as a basis of 3-D functions to represent the full shape of the crystalline lens ex vivo. Also, we presented the application of eigenlenses to estimate the full shape of the lens in vivo from 3-D optical coherence tomography (OCT) images, where only the central part of the lens -visible through the pupil- is available. The current work presents a validation of the use of eigenlenses to estimate in vivo the full shape of dis-accommodated lenses. We used 14 ex vivo crystalline lenses from donor eyes (11-54 y/o) mounted in a lens stretcher, and measured the geometry and the power of the lenses using a combined OCT and ray tracing aberrometry system. Ex vivo, the full extent of the lens is accessible from OCT because the incident light is not blocked by the iris. We measured in non-stretched (fully accommodated) and stretched (mimicking in vivo dis-accommodated lenses) conditions. Then, we simulated computationally in vivo conditions on the obtained ex vivo lenses geometry (assuming that just the portion of the lens within a given pupil is available), and estimated the full shape using eigenlenses. The mean absolute error (MAE) between estimated and measured lens’ diameters and volumes were MAE=0.26 ± 0.18 mm and MAE=7.0 ± 4.5 mm³, respectively. Furthermore, we concluded that the estimation error between measured and estimated lenses did not depend on the accommodative state (change in power due to stretching), and thus eigenlenses are also useful for the full shape estimation of in vivo dis-accommodated lenses.

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“…In particular, line acquisition speed increased from the 0.41 Hz of the first OCT image of the anterior segment [3], to the KHz using spectral domain OCT [4], or to MHz regime using swept sources [5,6]. With the increase in the acquisition speed, volumes of data can be acquired rapidly and the images can be quantified to study the 3D shape of the cornea and the crystalline lens [7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Effect of fixational eye movements in corneal topography measurements with optical coherence tomography

Castro¹,

Martinez-Enriquez²,

Marcos³

2023

Preprint

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There is an increasing interest in applying Optical Coherence Tomography (OCT) to quantify the topography of the ocular structures. However, in its most usual configuration, OCT data is acquired sequentially while a beam is scanned through the region of interest, and the presence of fixational eye movements can affect the accuracy of the technique. Several scan patterns and motion correction algorithms have been proposed to minimize this effect but there is no consensus on the ideal parameters to obtain a correct topography. We have acquired corneal OCT images, with raster and radial patterns, and modeled the data acquisition in the presence of eye movements. The simulations replicate the experimental variability in shape (radius of curvature and Zernike polynomials), corneal power, astigmatism, and calculated wavefront aberrations. The variability of the Zernike modes is highly dependent on the scan pattern, with higher variability in the direction of the slow scan axis. The model can be a useful tool to design motion correction algorithms and to determine the variability with different scan patterns.

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Simulating Outcomes of Cataract Surgery: Important Advances in Ophthalmology

Cited by 27 publications

References 148 publications

In vitro optical performance of multifocal and extended depth-of-focus intraocular lenses in spherical aberration conditions

In vitro optical performance of multifocal and extended depth-of-focus intraocular lenses in spherical aberration conditions

Estimation of the full shape of the crystalline lens from OCT: validation using stretched donor lenses

Effect of fixational eye movements in corneal topography measurements with optical coherence tomography

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