Simulation study of delivery of subnanosecond pulses to biological tissues with an impulse radiating antenna

Guo, Fei; Yao, Chenguo; Bajracharya, Chandra; Polisetty, Swetha; Schoenbach, K.H.; Xiao, Shu

doi:10.1002/bem.21825

Cited by 19 publications

(8 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, psPEFs were considered to have less impact on or result in less damage to surrounding biological tissue, which is of great importance to clinical application, especially in DBS. In addition, studies have shown that a psPEF has great performance in spatial orientation and can achieve electrical focus in breast tissue and even the brain [Guo et al, 2014] by matching impulse‐radiated antennas. Despite our study exploring how psPEFs regulated spike firing in an invasive method, our results showed that psPEF is promising to realize neuromodulation.…”

Section: Discussionmentioning

confidence: 99%

Picosecond Pulse Electrical Field Suppressing Spike Firing in Hippocampal CA1 in Rat In Vivo

Wang

Zhang³

et al. 2020

Bioelectromagnetics

Self Cite

View full text Add to dashboard Cite

Picosecond pulse electrical fields (psPEFs), due to their high temporal-resolution accuracy and localization, were viewed as a potential targeted and noninvasive method for neuromodulation. However, few studies have reported psPEFs regulating neuronal activity in vivo. In this paper, a preliminary study on psPEFs regulating action potentials in hippocampus CA1 of rats in vivo was carried out. By analyzing the neuronal spike firing rate in hippocampus CA1 pre-and post-psPEF stimulation, effects of frequency, duration, and dosimetry of psPEFs were studied. The psPEF used in this study had a pulse width of 500 ps and a field strength of 1 kV/mm, established by 1 kV picosecond voltage pulses. Results showed that the psPEF suppressed spike firing in hippocampal CA1 neurons. The suppression effect was found to be significant except for 10 s, 10 Hz. For shortduration stimulation (10 s), the inhibition rate of spike firing increased with frequency. At longer stimulation durations (1 and 2 min), the inhibition rate increased and decreased alternately as the frequency increased. Despite this, the inhibition rate at high frequencies (5 and 10 kHz) was significantly larger than that at 10 and 100 Hz. A cumulative effect of psPEF on spike firing inhibition was found at low frequencies (10 and 100 Hz), which was saturated when frequency reached 500 Hz or higher. This paper conducts a study on psPEF regulating spike firing in hippocampal CA1 in vivo for the first time and guides subsequent study on psPEF achieving noninvasive neuromodulation. Bioelectromagnetics. 2020;41:617-629.

show abstract

Section: Discussionmentioning

confidence: 99%

Picosecond Pulse Electrical Field Suppressing Spike Firing in Hippocampal CA1 in Rat In Vivo

Wang

Zhang³

et al. 2020

Bioelectromagnetics

Self Cite

View full text Add to dashboard Cite

show abstract

“…Except recently reported studies indicating the possibility of performing electroporation by magnetic fields [39,40] and radiated electromagnetic waves [41], the electric field required for electroporation is delivered by applying high voltages or currents across electrodes within or in contact with the tissue.…”

Section: How Can We Create Electric Fields For Electroporation?mentioning

confidence: 99%

Irreversible electroporation for the treatment of cardiac arrhythmias

Sugrue

Maor

Ivorra

et al. 2018

Expert Review of Cardiovascular Therapy

View full text Add to dashboard Cite

Cardiac ablation is an established treatment modality for the management of patients with cardiac arrhythmias. Current approaches to cardiac ablation employ thermal based energy to achieve lesions (damage) within the heart. There are many shortcomings and limitations of thermal based approaches. Electroporation (DC energy) is a non-thermal alternative approach to ablation that has shown significant promise in animal studies. Areas covered: An extensive review of the literature on the application of electroporation for ablation (both cardiac and collateral cardiac tissue) was undertaken. This review explores irreversible electroporation as a cardiac ablation modality. Specifically, it focuses and explains the biophysics of electroporation, the limitations of current thermal based approaches and examines the current data published on electroporation cardiac ablation. Expert commentary: Electroporation is a fast-growing novel ablation modality that has many advantages over current thermal based approaches. Current research in animal models shows its can be safely and efficaciously applied to the heart. Although further research is required, electroporation represents an appealing option for the ablation cardiac arrhythmias.

show abstract

“…More recently, at the same research center, a dielectric rod antenna was also suggested as a candidate for generating subnanosecond PEFs for the stimulation of neurological tissue [16]. All the three techniques have been theoretically investigated using CST software [15], [16], [17], with detailed numerical studies being reported. In contrast, very limited experimental work has been published, and only using rather low voltage subnanosecond pulsed power generators, with the resulting PEFs having extremely low peak values when compared with the values required for electroporation [18], [19], [20], the latter work representing an effort made at University of Limoges (France).…”

Section: Introductionmentioning

confidence: 99%

“…In contrast, very limited experimental work has been published, and only using rather low voltage subnanosecond pulsed power generators, with the resulting PEFs having extremely low peak values when compared with the values required for electroporation [18], [19], [20], the latter work representing an effort made at University of Limoges (France). For stimulating deep inside a tissue, say at 8 cm [17] using intense PEFs of some tens of kV/cm, published work suggest a subnanosecond pulsed power generator with a peak output voltage in excess of 250 kV is required [17]. Such a generator is technically extremely challenging.…”

Section: Introductionmentioning

confidence: 99%

A Subnanosecond Pulsed Electric Field System for Studying Cells Electropermeabilization

Ibrahimi¹,

Vallet²,

André³

et al. 2020

IEEE Trans. Plasma Sci.

View full text Add to dashboard Cite

This paper presents an experimental arrangement which, using 3-D numerical modeling, aims to study biomedical effects using subnanosecond pulsed electric fields. As part of a major effort into developing contactless technology, the final aim of this study is to determine the strength and pulse repetition frequency of the applied pulsed electric fields required to produce electropermeabilization. The arrangement uses a pulsed power generator producing voltage impulses with an amplitude of up to 20 kV on a 50 Ω matched load, with a rise time of 100 ps and a duration of 600 ps. During the preliminary study reported here, samples containing E. Coli were exposed to pulsed electric fields in a 4 mm standard electroporation cuvette, allowing the application of a peak electric field strength of up to 60 kV/cm. The studies were facilitated by detailed 3-D electromagnetic modeling of the electric field distribution generated by voltage impulses inside the system. Due to the nature of tests, the numerical analysis played an essential role in the interpretation of results. Preliminary biological results reported in this study are very encouraging, showing that trains of 5000 to 50000 pulses applied at a pulsed repetition frequency of 200 Hz can efficiently induce E. Coli electropermeabilization.

show abstract

Simulation study of delivery of subnanosecond pulses to biological tissues with an impulse radiating antenna

Cited by 19 publications

References 28 publications

Picosecond Pulse Electrical Field Suppressing Spike Firing in Hippocampal CA1 in Rat In Vivo

Picosecond Pulse Electrical Field Suppressing Spike Firing in Hippocampal CA1 in Rat In Vivo

Irreversible electroporation for the treatment of cardiac arrhythmias

A Subnanosecond Pulsed Electric Field System for Studying Cells Electropermeabilization

Contact Info

Product

Resources

About