Simultaneous analysis of chlorpyrifos and cypermethrin in cord blood plasma by online solid-phase extraction coupled with liquid chromatography–heated electrospray ionization tandem mass spectrometry

Liao, Hsin‐Tzu; Hsieh, Chia‐Jung; Chiang, Su‐Yin; Lin, Ming-Huan; Chen, Pau‐Chung; Wu, Kuen-Yuh

doi:10.1016/j.jchromb.2011.05.028

Cited by 39 publications

(16 citation statements)

References 22 publications

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“…The levels of pyrethroids and their residues in the blood of people exposed to pyrethroids are either very low (1 ppb) or undetectable (Ramesh and Ravi, 2004;Liao et al, 2011). The levels of pyrethroids and their residues in urine are usually higher (up to 1 mM) despite undetectable levels in the blood of the same people (Leng et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

Pyrethroids cypermethrin, deltamethrin and fenvalerate have different effects on in vitro maturation of pig oocytes at different stages of growth

Petr

Eva

Žalmanová

et al. 2013

Animal

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Pesticides can significantly harm reproduction in animals and people. Pyrethroids are often used as insecticides, and their toxicity for mammals is considered to be low. However, cypermethrin, deltamethrin and fenvalerate -as potent specific inhibitors of protein phosphatase calcineurin -can influence the meiosis of mammalian oocytes. The objective of this study was to evaluate the effects of these pyrethroids on the in vitro maturation of pig oocytes at different levels of meiotic competence. Under the tested concentrations, cypermethrin, deltamethrin and fenvalerate neither had a significant effect on the viability of oocytes nor did they induce significant degeneration of oocytes. However, these pyrethroids significantly affected meiotic maturation. The effects depended on the stage of meiotic competence of the oocytes. Maturation of growing pig oocytes with partial meiotic competence was induced. On the other hand, in fully grown pig oocytes with full meiotic competence, maturation in vitro was delayed. The specificity of these effects was further supported by the same effect of non-pyrethroidal inhibitors of calcineurin -cyclosporin A or hymenistatin I -on the maturation of oocytes with different levels of meiotic competence. However, pyrethroids, which do not inhibit calcineurin -allethrin or permethrin -had no effect on pig oocyte maturation. We demonstrated a significant effect of pyrethroids on the maturation of mammalian oocytes under in vitro conditions. This indicates that exposure to these substances could affect the fertility of people or animals.

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Section: Discussionmentioning

confidence: 99%

Pyrethroids cypermethrin, deltamethrin and fenvalerate have different effects on in vitro maturation of pig oocytes at different stages of growth

Petr

Eva

Žalmanová

et al. 2013

Animal

View full text Add to dashboard Cite

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“…As an alternative, LC-HRMS offers the possibility of detecting hundreds of polar contaminants in a quantitative target approach due to its sensitivity and selectivity in full-scan analysis. Furthermore, it allows the detection of known compounds suspected of being present in environmental samples (suspect screening) without reference standards, even after measurement (post-target screening) and the screening of yet unknown non-target chemicals [87][88]. The use of HRMS, such as TOF or Orbitrap, for multiresidue analysis is largely driven by the advantages of using the full-scan acquisition mode with high sensitivity, combined with high-resolving power (> 50000 FWHM) and accurate mass measurement (1-5 ppm) [89].…”

Section: Instrumental Techniquesmentioning

confidence: 99%

Analytical methods for human biomonitoring of pesticides. A review

Yusà

Millet

Coscollà

et al. 2015

Analytica Chimica Acta

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“…The pesticides and their product ions were confirmed via comparison of their mass spectra with those from an analytical protocol provided by the Taiwan Food and Drug Administration (TFDA) and other relevant references. [21][22][23][24][25] The experimental results indicate that point-of-care application of TD-ESI-MS for simultaneous identification of multiple pesticide compounds is achievable.…”

Section: Ms/ms Analysis (Data Not Shown) the Results Of The Ms And Mmentioning

confidence: 93%

Rapid identification of organophosphorus pesticides on contaminated skin and confirmation of adequate decontamination by ambient mass spectrometry in emergency settings

Yeh

et al. 2020

Rapid Comm Mass Spectrometry

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Rationale Dermal exposure to pesticides may cause severe intoxication and even result in a fatal outcome. To expedite rescue in the emergency department, it is mandatory to develop a point‐of‐care analytical method for immediate identification of pesticides on the skin of exposed personnel, and to perform immediate dermal decontamination to prevent further harm and optimize the chance for full clinical recovery. Methods Four of the most commonly used highly toxic pesticides that contaminate the skin were rapidly characterized by thermal desorption electrospray ionization mass spectrometry. The technique was also applied to confirm the completeness of pesticide decontamination from the skin. Pesticide sampling, desorption, ionization, and detection altogether took less than 30 s. In addition, different fabrics of protective garments worn by farmers were assessed with this efficient ambient mass spectrometric technique for their protective capabilities against dermal exposure to pesticides, and scanning electron microscopy was used to observe their different microstructures. The decontaminating efficacies of different cleansing agents for these skin contaminants were also evaluated by this technical platform. Results The repeatability of this method had a low relative standard deviation (<22%) for the detection of pesticides on the surface of swine skin. The detection limits of the pesticides in solution were found to be in the range of 3–20 ng/mL. Linearity was observed between the signal intensities and the concentrations of the four pesticides in solution within the range of 50 ng/mL to 50 μg/mL (R2 between 0.9921 and 0.9966). In addition, it was found that PVC fabric is optimal in preventing skin contamination by fenthion and detergent had the best efficiency for fenthion decontamination. Conclusions Since the whole analytical process is extremely fast, this technique allows early point‐of‐care identification of contaminating pesticides on the skin of exposed patients in the emergency room, as well as rapid assessment of the adequacy of decontamination.

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Simultaneous analysis of chlorpyrifos and cypermethrin in cord blood plasma by online solid-phase extraction coupled with liquid chromatography–heated electrospray ionization tandem mass spectrometry

Cited by 39 publications

References 22 publications

Pyrethroids cypermethrin, deltamethrin and fenvalerate have different effects on in vitro maturation of pig oocytes at different stages of growth

Pyrethroids cypermethrin, deltamethrin and fenvalerate have different effects on in vitro maturation of pig oocytes at different stages of growth

Analytical methods for human biomonitoring of pesticides. A review

Rapid identification of organophosphorus pesticides on contaminated skin and confirmation of adequate decontamination by ambient mass spectrometry in emergency settings

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