Simultaneous assessment of cognitive and affective functions in multiple system atrophy and cortical cerebellar atrophy in relation to computerized touch-panel screening tests

Kawahara, Yuko; Ikeda, Yoshio; Deguchi, Kentaro; Kurata, Tomoko; Hishikawa, Nozomi; Sato, Kota; Kono, Syoichiro; Yunoki, Taijun; Omote, Yoshio; Yamashita, Toru

doi:10.1016/j.jns.2015.02.010

Cited by 22 publications

(23 citation statements)

References 36 publications

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“…So far, few studies have addressed the possible differences between patients with predominant cerebellar or parkinsonian presentation, and the focus has been mainly on MSA‐P patients. In this study, a comparison of raw scores revealed lower performance of MSA‐C patients than MSA‐P patients in a screening of executive functions and in phonological verbal fluency.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, severe cognitive decline that significantly disrupts daily living is uncommon in MSA; hence, dementia has been regarded as a nonsupporting feature in the current diagnostic criteria . Comparative studies on cognitive impairment in both motor subtypes have been conducted but reported heterogeneous results . Kawai and colleagues observed a multidomain cognitive decline in MSA‐P but not in MSA‐C .…”

Section: Introductionmentioning

confidence: 99%

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Cognition in multiple system atrophy: a single‐center cohort study

Eschlböck

Delazer

Krismer

et al. 2020

Ann Clin Transl Neurol

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Objective Cognitive impairment in multiple system atrophy (MSA) is common, but remain poorly characterized. We evaluated cognitive and behavioral features in MSA patients and assessed between‐group differences for MSA subtypes and the effect of orthostatic hypotension (OH) on cognition. Methods This retrospective study included 54 patients with clinical diagnosis of possible and probable MSA referred to the Department of Neurology at Medical University of Innsbruck between 2000 and 2018. Neurological work‐up included comprehensive neuropsychological testing including Consortium to Establish a Registry for Alzheimer's Disease (CERAD‐plus) test battery, Frontal Assessment Battery (FAB), digit span test (DST), clock drawing task (CLOX1), and Hospital Anxiety and Depression Scale (HADS‐D). Results The mean MMSE score was 27.6 points. Overall, slight to moderate cognitive impairment was noted in up to 40% of patients, with predominant impairment of executive function and verbal memory. Patients with the cerebellar variant performed significantly worse than patients with the parkinsonian type (P < 0.05) in a screening of executive functions (FAB) and in phonemic verbal fluency. Depression and anxiety scores were elevated in 28% and 22% of MSA patients, respectively. Cognitive profile, depression, and anxiety levels were comparable between patients with and without OH. Interpretation Cognitive deficits are relatively frequent in MSA and primarily affect executive functions and verbal memory. Future comparative studies including Parkinson dementia, Lewy body disease, and MSA cases with and without OH are required to elucidate disease‐specific cognitive profiles in these synucleinopathies and to examine the influence of cardiovascular autonomic dysfunction on cognitive function in MSA.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cognition in multiple system atrophy: a single‐center cohort study

Eschlböck

Delazer

Krismer

et al. 2020

Ann Clin Transl Neurol

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“…Participants were evaluated with neurological examinations, the CDR, and the following cognitive tests: MMSE, Hasegawa Dementia Score‐Revised (HDS‐R), Frontal Assessment Battery (FAB), the Montreal Cognitive Assessment (MoCA) and a computerized touch‐panel test called “Ryokansan” (Ohtsu Computer, Otsu, Japan). The Ryokansan program was used according to our previous reports, which included the times (s) to complete the flipping card, finding the mistakes and picture arrangement games, and accuracy (%) on the beat the devils game . The flipping card game assesses the time to find six matching pairs of cards.…”

Section: Methodsmentioning

confidence: 99%

“…The beat the devils game asks participants to distinguish between the emergence of heroes and devils, and assesses accuracy in exterminating only devils during a 30‐s period. The flipping the card game reflects recent memory and concentration, the finding the mistakes game reflects the ability to discriminate and attention, the picture arrangement game reflects long‐term memory and logical thinking, and the beat the devil game reflects judgment speed and inhibitory control . Depression, apathy, and behavioral and psychological symptoms of dementia were evaluated with the Geriatric Depression Scale (GDS), Apathy Scale (AS) and Abe's Behavioral and Psychological Symptoms of Dementia Score (ABS), respectively …”

Section: Methodsmentioning

confidence: 99%

Clinical features of incidental mild cognitive impairment and dementia in a population‐based study

Hishikawa

Fukui

Sato

et al. 2016

Geriatrics Gerontology Int

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“…The works referenced tackle a specific aspect of the broader topic of the introduction of games in neuroscience to detect mental disorders such as Mild Cognitive Impairment (MCI) (Nolin et al, 2013; Raspelli et al, 2011; Werner et al, 2009; Aalbers et al, 2013; Tarnanas et al, 2013; Kawahara et al, 2015; Fukui et al, 2015), Alzheimer’s Disease (AD) (Tarnanas et al, 2013; Kawahara et al, 2015; Fukui et al, 2015), Traumatic Brain Injury (TBI) (Wilson et al, 1989; Canty et al, 2014), Chronic Fatigue Syndrome (CFS) (Attree, Dancey & Pope, 2009), or Attention Deficit Hyperactivity Disorder (ADHD) (Parsons et al, 2007; Pollak et al, 2009). …”

Section: Introductionmentioning

confidence: 99%

Design process and preliminary psychometric study of a video game to detect cognitive impairment in senior adults

Valladares-Rodríguez

Pérez‐Rodríguez

Facal

et al. 2017

PeerJ

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IntroductionAssessment of episodic memory has been traditionally used to evaluate potential cognitive impairments in senior adults. Typically, episodic memory evaluation is based on personal interviews and pen-and-paper tests. This article presents the design, development and a preliminary validation of a novel digital game to assess episodic memory intended to overcome the limitations of traditional methods, such as the cost of its administration, its intrusive character, the lack of early detection capabilities, the lack of ecological validity, the learning effect and the existence of confounding factors.Materials and MethodsOur proposal is based on the gamification of the California Verbal Learning Test (CVLT) and it has been designed to comply with the psychometric characteristics of reliability and validity. Two qualitative focus groups and a first pilot experiment were carried out to validate the proposal.ResultsA more ecological, non-intrusive and better administrable tool to perform cognitive assessment was developed. Initial evidence from the focus groups and pilot experiment confirmed the developed game’s usability and offered promising results insofar its psychometric validity is concerned. Moreover, the potential of this game for the cognitive classification of senior adults was confirmed, and administration time is dramatically reduced with respect to pen-and-paper tests.LimitationsAdditional research is needed to improve the resolution of the game for the identification of specific cognitive impairments, as well as to achieve a complete validation of the psychometric properties of the digital game.ConclusionInitial evidence show that serious games can be used as an instrument to assess the cognitive status of senior adults, and even to predict the onset of mild cognitive impairments or Alzheimer’s disease.

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Simultaneous assessment of cognitive and affective functions in multiple system atrophy and cortical cerebellar atrophy in relation to computerized touch-panel screening tests

Cited by 22 publications

References 36 publications

Cognition in multiple system atrophy: a single‐center cohort study

Cognition in multiple system atrophy: a single‐center cohort study

Clinical features of incidental mild cognitive impairment and dementia in a population‐based study

Design process and preliminary psychometric study of a video game to detect cognitive impairment in senior adults

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