Simultaneous chiral analysis of methamphetamine and related compounds by capillary electrophoresis

Chiral separation in capillary electrophoresis using dual neutral cyclodextrins: Theoretical models of electrophoretic mobility difference and separation selectivity

“…3. Migration order and identification of each peak in electropherograms were obtained by spiking a single isomer and comparing with previous work [33,39]. EP enantiomers were found to have reversed migration order for b-CD and DM-b-CD, while the same migration orders were obtained for other enantiomers.…”

“…One approach to enhance the simultaneous separation of all analytes is the use of dual CDs, a combination of two CD types, in the BGE. The following dual neutral CDs have been shown to improve simultaneous separation of several pairs of enantiomers: b-and g-CDs for Dns-DL-amino acids [29], a-and trimethyl-b-cyclodextrins (TM-b-CDs) for binaphthyl compounds [30], b-and TM-b-CDs or g-and TM-b-CDs for phenoxy acid herbicides [31], b-and g-CDs for polychlorinated biphenyls [32], and b-and DM-b-CDs for amphetamine (AP) drugs [33]. In comparison with a single charged CD, dual chiral selectors as neutral and charged CDs have been reported to provide benefit of better resolution and peak shape [34].…”

“…The use of dual CDs may result in improvement of Dm and a for some enantiomers, and a loss of Dm and a for other enantiomers [21,[29][30][31][32][33]. The aims of this work are to develop equations and theoretical models of electrophoretic mobility difference and separation selectivity, related to the dimensionless values of enantioselectivity and KC, for enantiomers in CE using dual neutral CDs, and to compare theory and practice of electrophoretic mobility difference and separation selectivity.…”

Simultaneous Chiral Analysis of Methamphetamine and Related Compounds by Capillary Electrophoresis/Mass Spectrometry Using Anionic Cyclodextrin

“…The same compounds were previously analyzed by Chinaka et al by CE/diode-array detection (DAD) using 75 mM tris(hydroxymethyl)-aminomethane (Tris) buffer as a background electrolyte, and the same CDs as a chiral selector. 4 The resolutions of these compounds are also shown in the right part of Table 1. Using Tris, neutral CDs and a DAD detector, the chiral resolutions of all compounds, except AP, were over 1, but, using formic acid, neutral CDs and the MS detector, the chiral resolutions of all compounds, except NE, were under 1.…”

Chiral Capillary Electrophoresis of Amphetamine-Type Stimulants

“…8) The electrolyte was Tris buffer (pH 2.5) containing β-CD and heptakis(2,6-di-O-methyl)-β-CD (DM-β-CD). This method successfully separated all 18 enantiomers simultaneously (Fig.…”