Simultaneous determination of 19 constituents in Cimicifugae Rhizoma by HPLC–DAD and screening for antioxidants through DPPH free radical scavenging assay

Niu, Xueni; Qin, Ru-Lan; Zhao, Yongdan; Ling, Han; Lu, Jincai; Lv, Chongning

doi:10.1002/bmc.4624

Cited by 13 publications

(8 citation statements)

References 18 publications

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“…The data by Nuntanakorn et al (2007) also indicate contents at or less than 1% in several Actaea species. Similarly, contents of about or less than 0.1% of the dry weight have been determined by Niu et al (2019) in various Actaea species. Since the amounts of the hydroxycinnamic acids in plant material is rather restricted and only few plant species are known to produce these fukinolic and cimicifugic acids, biological activities requiring higher concentrations of these compounds do not appear to be promising to be exploited in near future.…”

Section: Discussionmentioning

confidence: 99%

Fukinolic acid and cimicifugic acids: a review

Jahn

Petersen

2021

Phytochem Rev

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During the last decades, the research on the biological activities of extracts from Cimicifuga/Actaea species and Petasites japonicus as well as their active ingredients has been intensified. Besides terpenoids as dominant natural product group, hydroxycinnamic acid esters such as fukinolic acid and several cimicifugic acids have been isolated from Actaea and Petasites species and their chemical structures have been elucidated. Investigations on the biological properties of these hydroxycinnamic acid esters are currently undertaken and some compounds might be promising therapeutic tools. In this review, we have gathered information on the genera Actaea and Petasites, the occurrence of cimicifugic and fukinolic acids and some aspects of their biosynthesis. Furthermore, we have summarized the medicinal aspects of fukinolic acid and cimicifugic acids. In connection with the biological activities of these compounds, structural features of the hydroxycinnamic acid derivatives move into the focus. The position of the hydroxyl group at the aromatic rings and the introduction of an electron-donating moiety may be important for anti-inflammatory, antiviral, cytotoxic and vasoactive effects of these compounds.

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Section: Discussionmentioning

confidence: 99%

Fukinolic acid and cimicifugic acids: a review

Jahn

Petersen

2021

Phytochem Rev

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“…The increase of phenolic content was positively correlated with antioxidant activity. The antioxidant activity of 2-feruloyl piscidic acid (IC 50 = 9.33 μM) and 2-isoferuloyl piscidic acid (IC 50 = 15.62 μM) was evaluated by DPPH free radical scavenging activity test and the content of phenolic acid was positively correlated with antioxidant activity [ 86 ]. Phenolic hydroxyl group of the benzene ring and a highly conjugated side chain in the opposite position benefited to the delocalization and stability of the phenoxy group in the whole molecule, which played a strong antioxidant capacity [ 87 ].…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

Traditional uses, phytochemistry, pharmacology, quality control and clinical studies of Cimicifugae Rhizoma: a comprehensive review

Zhang,

Wei,

Jin

et al. 2024

Chin Med

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Cimicifugae Rhizoma, generally known as “Sheng Ma” in China, has great medicinal and dietary values. Cimicifugae Rhizoma is the dried rhizome of Cimicifuga foetida L., Cimicifuga dahurica (Turcz.) Maxim. and Cimicifuga heracleifolia Kom., which has been used to treat wind-heat headache, tooth pain, aphtha, sore throat, prolapse of anus and uterine prolapse in traditional Chinese medicine. This review systematically presents the traditional uses, phytochemistry, pharmacology, clinical studies, quality control and toxicity of Cimicifugae Rhizoma in order to propose scientific evidence for its rational utilization and product development. Herein, 348 compounds isolated or identified from the herb are summarized in this review, mainly including triterpenoid saponins, phenylpropanoids, chromones, alkaloids, terpenoids and flavonoids. The crude extracts and its constituents had various pharmacological properties such as anti-inflammatory, antitumor, antiviral, antioxidant, neuroprotective, anti-osteoporosis and relieving menopausal symptoms. The recent research progress of Cimicifugae Rhizoma in ethnopharmacology, phytochemistry and pharmacological effects demonstrates the effectiveness of its utilization and supplies valuable guidance for further research. This review will provide a basis for the future development and utilization of Cimicifugae Rhizoma.

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“…Actaea cimicifuga L. is a common herbal remedy documented in editions of the pharmacopoeia of China. The dried roots of cimicifuga, known as Cimicifuga heracleifolia Kom., have been vastly utilized as the source of Chinese herbal medicine Sheng Ma in terms of its antipyretic, anti-inflammatory, and antioxidative effects (Niu et al, 2019). To evaluate the efficacy of Cimicifuga Rhizoma extract (CRE) on asthma, the mice (Lim et al, 2021;Pang et al, 2021) were administrated CRE orally at 30 and 100 mg/kg.…”

Section: The Traditional Herbs In Inhibiting Airway Inflammation and ...mentioning

confidence: 99%

The Role and Mechanisms of Traditional Chinese Medicine for Airway Inflammation and Remodeling in Asthma: Overview and Progress

2022

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Asthma as an individual disease has blighted human health for thousands of years and is still a vital global health challenge at present. Though getting much progress in the utilization of antibiotics, mucolytics, and especially the combination of inhaled corticosteroids (ICS) and long-acting β-agonists (LABA), we are confused about the management of asthmatic airway inflammation and remodeling, which directly threatens the quality of life for chronic patients. The blind addition of ICS will not benefit the remission of cough, wheeze, or sputum, but to increase the risk of side effects. Thus, it is necessary to explore an effective therapy to modulate asthmatic inflammation and airway remodeling. Traditional Chinese Medicine (TCM) has justified its anti-asthma effect in clinical practice but its underlying mechanism and specific role in asthma are still unknown. Some animal studies demonstrated that the classic formula, direct exacts, and natural compounds isolated from TCM could significantly alleviate airway structural alterations and exhibit the anti-inflammatory effects. By investigating these findings and data, we will discuss the possible pathomechanism underlined airway inflammation and remodeling in asthma and the unique role of TCM in the treatment of asthma through regulating different signaling pathways.

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Simultaneous determination of 19 constituents in Cimicifugae Rhizoma by HPLC–DAD and screening for antioxidants through DPPH free radical scavenging assay

Cited by 13 publications

References 18 publications

Fukinolic acid and cimicifugic acids: a review

Fukinolic acid and cimicifugic acids: a review

Traditional uses, phytochemistry, pharmacology, quality control and clinical studies of Cimicifugae Rhizoma: a comprehensive review

The Role and Mechanisms of Traditional Chinese Medicine for Airway Inflammation and Remodeling in Asthma: Overview and Progress

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