Simultaneous determination of bromate, chlorite and haloacetic acids by two-dimensional matrix elimination ion chromatography with coupled conventional and capillary columns

High-throughput and reliable determination of 13 haloacetic acids and dalapon in water and evaluation of control strategies

“…10 Compared to other methods previously published for the analysis of this class of DBPs, the approach here presented allows the simultaneous determination of dalapon and the 13 HAAs for which analytical standards are available in an extremely short analysis time (16 min per sample vs. 20-25 min (ref. 22, 26 and 34) in other LC-MS approaches or 27 min to 65 min in IC-MS-based methods [29][30][31][32] ). Shorter analysis times (<10 min) were only reported for UPLC-MS approaches.…”

“…Several methodologies focused on the direct injection of the water sample into the analytical instrument have been also proposed to bypass the extraction step. [25][26][27][28][29][30][31][32][33] The main advantage of direct injection methods is that sample treatment is reduced to internal standard addition and sample filtration, and consequently, the total analysis time is shortened.…”

“…The development of direct injection methods requires the use of highly selective analytical techniques, like those consisting of chromatographic separation of the sample components and MS determination of the target analytes. Chromatography has been achieved with ion exchange columns (ion chromatography, IC) [29][30][31][32] or reversed-phase columns (reversed-phase liquid chromatography, RPLC, or LC) packed with a silica-based sorbent modified to enhance the retention of polar analytes. 24,26,28,33,34 IC-MS/MS has been successfully used for the quantitative analysis of up to 13 HAAs and dalapon in water at levels in the low μg L −1 range (LOQs below 1 μg L −1 ).…”

Theory and Practice of UHPLC and UHPLC–MS

“…Different SPs have been employed for this purpose, such as PEG monolith (Rahayu et al, 2015) or anion-exchange sorbents (Rodriguez et al, 2015;Teh and Li, 2015). An interesting example of these applications is the one by Teh and Li (2015), who developed a two-dimensional matrix elimination ion chromatographic method. A high capacity 4 mm I.D.…”

“…Other environmental applications involve the determination of inorganic and organic small anions (Rahayu et al, 2015;Rodriguez et al, 2015;Teh and Li, 2015). Different SPs have been employed for this purpose, such as PEG monolith (Rahayu et al, 2015) or anion-exchange sorbents (Rodriguez et al, 2015;Teh and Li, 2015).…”