Simultaneous determination of Cr(iii) and Cr(vi) using reversed-phased ion-pairing liquid chromatography with dynamic reaction cell inductively coupled plasma mass spectrometry

Wolf, Ruth E.; Morrison, Jean M.; Goldhaber, Martin B.

doi:10.1039/b704597b

Cited by 68 publications

(73 citation statements)

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“…The observation demonstrates that pepsin, bile, and pancreatin could not reduce Cr(VI). Our results were also in contrast to a previous hypothesis that ingested Cr(VI) might be reduced to Cr(III) because the extreme low pH condition of the stomach favours the Cr(VI) reduction [31,32]. The Eh-pH diagram (SD Fig.…”

Section: Reduction Of Cr(vi) In Ivg Fluidscontrasting

confidence: 99%

Evaluation of chromium bioaccessibility in chromite ore processing residue using in vitro gastrointestinal method

Luo

et al. 2012

Journal of Hazardous Materials

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a b s t r a c tIncidental ingestion of Chromite ore processing residue (COPR) particles poses a potential health risk. The purpose of this study was to determine the Cr bioaccessibility from COPR using the in vitro gastrointestinal (IVG) procedure. The bioaccessible Cr(VI) was 53.8% and 42.9%, respectively, in the gastric and intestinal phases from a total of 19 490 mg kg −1 Cr(VI) in COPR. Food intake including milk, dough, and ascorbic acid resulted in a significant decrease in Cr(VI) bioaccessibility. Some organic acids such as lactic, malic, and citric acid moderately reduced Cr(VI), while acetic acid exhibited no capacity for Cr(VI) reduction. The integrated area under the concentration-time curve (AUC) of the IVG extraction was used to calculate bioaccessibility. Compared with the bioaccessibility conventionally estimated using concentrations at the end of the extraction (CEP), the AUC technique should be implemented to confirm the accuracy of the IVG method when reduction of Cr(VI) occurs during the extraction. The absence of Cr(VI) phases in extracted residues as evidenced by XANES and XRPD analysis confirmed the Cr(VI) release and Cr(VI) reduction by food and ascorbic acid. With readily bioaccessible Cr(VI) and rapid human uptake, reduction of Cr(VI) might not be as effective a detoxification pathway as initially thought.

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Section: Reduction Of Cr(vi) In Ivg Fluidscontrasting

confidence: 99%

Evaluation of chromium bioaccessibility in chromite ore processing residue using in vitro gastrointestinal method

Luo

et al. 2012

Journal of Hazardous Materials

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“…As can be seen from the chromatogram, retention times are 1.42 min and 1.92 min for Cr(III) and Cr(VI), respectively. Compared to previous experiments [12,[15][16][17], the reported retention times are similar or slightly higher.…”

Section: Selectivity and Specificitymentioning

confidence: 58%

“…For this process, following other researches [12,[15][16][17] [12,15,16], methanol was not adopted in the presented article. It is known that, the addition of an organic solvent to the mobile phase leads to a shortening of the retention times of organic forms and to narrowing peaks.…”

Section: Methods Developmentmentioning

confidence: 99%

“…The obtained results were 1.5 and 1.6 % for Cr(III) and Cr(VI), respectively. Outcomes of presented repeatability here corresponded with values released previously [12,15].…”

Section: Precisionmentioning

confidence: 99%

“…and thus improves the sensitivity of chromium analysis [9]. The chromatographic methods for chromium speciation analysis may involve either ion chromatography (IC) [10,11] or ion-pair reversed-phase chromatography (RPIPC) [12,13]. RPIP-HPLC is widely used as a simple, flexible and sensitive method for separating chromium compounds.…”

Section: Introductionmentioning

confidence: 99%

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Speciation analysis of chromium in drinking water samples by ion-pair reversed-phase HPLC–ICP-MS: validation of the analytical method and evaluation of the uncertainty budget

et al. 2013

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The approach presented in this article refers to the modification of a method for the detection and quantitative determination of chromium species in water by high-performance liquid chromatography inductively coupled plasma mass spectrometry. The main aim of this work was to establish a detailed validation of the analytical procedure and an estimation of the budget of measurement uncertainty which was helpful in recognizing the critical points of the presented method. As a result of the method validation experiment, the obtained limit of quantification, repeatability and intermediate precision were satisfied for the quantification Cr(III) and Cr(VI) in water matrices. The trueness of the method was verified via an estimation of the recovery of the spiked real samples. The recovery rate of both determined analytes was found to be between 93 and 115 %. Considering that the validation of the method and the evaluation of measurement uncertainty are crucial for quantitative analysis, the above-mentioned assessment of the uncertainty budget was performed in two different ways: a modelling approach and a single-laboratory validation approach. The measurement uncertainties of the results were found to be 4.4 and 7.8 % for Cr(III), 4.2 and 7.9 % for Cr(VI) using the classical concept and method validation data, respectively. This paper is the first publication to presenting all the steps needed to evaluate the measurement uncertainty for the speciation analysis of chromium species. In summary, the obtained results demonstrate that the method can be applied effectively for its intended use.

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show abstract

Simultaneous determination of Cr(iii) and Cr(vi) using reversed-phased ion-pairing liquid chromatography with dynamic reaction cell inductively coupled plasma mass spectrometry

Cited by 68 publications

References 23 publications

Evaluation of chromium bioaccessibility in chromite ore processing residue using in vitro gastrointestinal method

Evaluation of chromium bioaccessibility in chromite ore processing residue using in vitro gastrointestinal method

Speciation analysis of chromium in drinking water samples by ion-pair reversed-phase HPLC–ICP-MS: validation of the analytical method and evaluation of the uncertainty budget

Current literature in mass spectrometry

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