Simultaneous determination of dopamine and serotonin using a carbon nanotubes-ionic liquid gel modified glassy carbon electrode

Sun, Yue; Fei, Junjie; Hou, Jie; Zhang, Qin; Liu, Yanling; Hu, Benan

doi:10.1007/s00604-009-0147-1

Cited by 97 publications

(35 citation statements)

References 39 publications

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“…Until now, the modified electrodes demonstrated the electrochemical response of 5-HT to be smaller than that of DA. 4,40 These results suggest that, in the presence of DA, the concentrations of 5-HT can be selectively determined with excellent sensitivity. It is possible that the amino group of the 5-HT is more electroactive than that of DA, according to structure.…”

Section: Resultsmentioning

confidence: 78%

“…This modified electrode was employed for electrochemical selective determination of 5-HT in the comparable presence of DA, UA, and excess AA, with a linear response range of 1.0 × 10 −7 to 1.0 × 10 −5 M, under a biologically and analytically significant pH of 7.4; this was comparable to recent literature values. 4,5,40 The respective detection limit and correlation coefficient were calculated as 5.0 nM and 0.998 on the anodic current.…”

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confidence: 99%

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Selective Determination of Serotonin on Poly(3,4-ethylenedioxy pyrrole)-single-walled Carbon Nanotube-Modified Glassy Carbon Electrodes

Kim¹,

Bae²,

Ahmed³

et al. 2011

Bulletin of the Korean Chemical Society

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An electrochemically-modified electrode [P(EDOP-SWNTs)/GCE] was prepared by electropolymerization of 3,4-ethylenedioxy pyrrole (EDOP) single-walled carbon nanotubes (SWNTs) on the surface of a glassy carbon electrode (GCE) and characterized by SEM, CV, and DPV. This modified electrode was employed as an electrochemical biosensor for the selective determination of serotonin concentrations at pH 7.4 and exhibited a typical enhanced effect on the current response of serotonin with a lower oxidation overpotential. The linear response was in the range of 1.0 × 10 −7 to 1.0 × 10 −5 M, with a correlation coefficient of 0.998 on the anodic current. The lower detection limit was calculated as 5.0 nM. Due to the relatively low currents and difference of potentials in the electrochemical responses of uric acid (UA), ascorbic acid (AA), and dopamine (DA), the modified electrode was a useful and effective sensing device for the selective and sensitive serotonin determination in the presence of UA, AA, and DA.

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Section: Resultsmentioning

confidence: 78%

mentioning

confidence: 99%

Selective Determination of Serotonin on Poly(3,4-ethylenedioxy pyrrole)-single-walled Carbon Nanotube-Modified Glassy Carbon Electrodes

Kim¹,

Bae²,

Ahmed³

et al. 2011

Bulletin of the Korean Chemical Society

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“…42 They have excellent chemical and physical properties such as good chemical and thermal stability, wide electrochemical windows and high ionic conductivity. [43][44][45][46] When a gels is made by grinding the mixture of imidazolium ion-based RTILs and pristine single-walled CNTs, CNTs have good performance of electrochemical characteristics as the phenomenon of agglomeration and cross-linking of CNTs can be mediated by RTILS because of the "cation-π" of strong interactions between RTILs and CNTs. 47,48 Thus, the combination of the RTILs and CNTs can get a favorable fabrication of the modified electrode which can be successfully applied in the catalysis of bioelectrochemical reaction, fabrication of biosensors and the determination of the various biomolecules.…”

Section: Introductionmentioning

confidence: 99%

Electrocatalytic Oxidation of Venlafaxine at a Multiwall Carbon Nanotubes-Ionic Liquid Gel Modified Glassy Carbon Electrode and Its Electrochemical Determination

Ding

Li²,

You

et al. 2015

Croat. Chem. Acta

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Abstract. The electrocatalytic oxidation of venlafaxine (VEN) was investigated at a glassy carbon electrode (GCE), the modified electrode by a gel containing multiwall carbon nanotubes (MWCNTs) and a room-temperature ionic liquid (RTIL), 1-butyl-3-methylimidazolium hexafluorophate (BMIMPF 6 ) in 0.10 mol L −1 phosphate buffer solution (PBS, pH 6.8). It was found that an irreversible anodic oxidation peak of VEN with the peak potential (E pa ) as 0.780 V appeared at MWCNTs-RTIL/GCE. The electrode reaction process was a diffusion-controlled one and the electrochemical oxidation involved two electrons transferring and two protons participation. Furthermore, the charge-transfer coefficient (α), and the electrode reaction rate constant (k f ) of VEN were found to be 0.91 and 3.04×10 −2 s −1 , respectively. Under the optimized conditions, the electrocatalytic oxidation peak currents were linearly dependent on the concentration of VEN in the concentration range from 2.0×10 −6 mol L −1 ~ 2.0×10 −3 mol L −1 with the limit of detection (S / N = 3) as 1.69×10−6 mol L −1 . The proposed method has been successfully applied in the electrochemical quantitative determination of VEN content in commercial venlafaxine hydrochloride capsules and the determination results could meet the requirement of the quantitative determination.

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“…A MWCNT-IL composite is capable of simultaneous detection of serotonin and DA (Sun et al, 2009). AA and other endogenous substrates such as glucose, NaCl, UA, purine, L-histidine and L-cysteine do not provoke any signal response.…”

Section: Neurotransmitters/neurochemicalsmentioning

confidence: 99%

Advances in carbon nanotube based electrochemical sensors for bioanalytical applications

Vashist

Zheng

Al‐Rubeaan

et al. 2011

Biotechnology Advances

407

218

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Electrochemical (EC) sensing approaches have exploited the use of carbon nanotubes (CNTs) as electrode materials owing to their unique structures and properties to provide strong electrocatalytic activity with minimal surface fouling. Nanofabrication and device integration technologies have emerged along with significant advances in the synthesis, purification, conjugation and biofunctionalization of CNTs. Such combined efforts have contributed towards the rapid development of CNT-based sensors for a plethora of important analytes with improved detection sensitivity and selectivity. The use of CNTs opens an opportunity for the direct electron transfer between the enzyme and the active electrode area. Of particular interest are also excellent electrocatalytic activities of CNTs on the redox reaction of hydrogen peroxide and nicotinamide adenine dinucleotide, two major by-products of enzymatic reactions. This excellent electrocatalysis holds a promising future for the simple design and implementation of on-site biosensors for oxidases and dehydrogenases with enhanced selectivity. To date, the use of an anti-interference layer or an artificial electron mediator is critically needed to circumvent unwanted endogenous electroactive species. Such interfering species are effectively suppressed by using CNT based electrodes since the oxidation of NADH, thiols, hydrogen peroxide, etc. by CNTs can be performed at low potentials. Nevertheless, the major future challenges for the development of CNT-EC sensors include miniaturization, optimization and simplification of the procedure for fabricating CNT based electrodes with minimal non-specific binding, high sensitivity and rapid response followed by their extensive validation using "real world" samples. A high resistance to electrode fouling and selectivity are the two key pending issues for the application of CNT-based biosensors in clinical chemistry, food quality and control, waste water treatment and bioprocessing.

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Simultaneous determination of dopamine and serotonin using a carbon nanotubes-ionic liquid gel modified glassy carbon electrode

Cited by 97 publications

References 39 publications

Selective Determination of Serotonin on Poly(3,4-ethylenedioxy pyrrole)-single-walled Carbon Nanotube-Modified Glassy Carbon Electrodes

Selective Determination of Serotonin on Poly(3,4-ethylenedioxy pyrrole)-single-walled Carbon Nanotube-Modified Glassy Carbon Electrodes

Electrocatalytic Oxidation of Venlafaxine at a Multiwall Carbon Nanotubes-Ionic Liquid Gel Modified Glassy Carbon Electrode and Its Electrochemical Determination

Advances in carbon nanotube based electrochemical sensors for bioanalytical applications

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