Simultaneous determination of four alkaloids in Lindera aggregata by ultra-high-pressure liquid chromatography–tandem mass spectrometry

Han, Zheng; Zheng, Yang; Chen, Na; Luan, Lianjun; Zhou, Chang‐Xin; Gan, Li‐She; Wu, Yongjiang

doi:10.1016/j.chroma.2008.10.017

Cited by 50 publications

(31 citation statements)

References 12 publications

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“…The LOD and LOQ values were 0.5 and 1 ng/ml, respectively. Four alkaloids in Lindera aggregate were determined using UHPLC-MS/MS in less than 6.5 min [174].…”

Section: Alkaloidsmentioning

confidence: 99%

Recent developments in qualitative and quantitative analysis of phytochemical constituents and their metabolites using liquid chromatography–mass spectrometry

Guo

Chen

et al. 2013

Journal of Pharmaceutical and Biomedical Analysis

167

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“…The LOD and LOQ values were 0.5 and 1 ng/ml, respectively. Four alkaloids in Lindera aggregate were determined using UHPLC-MS/MS in less than 6.5 min [174].…”

Section: Alkaloidsmentioning

confidence: 99%

Recent developments in qualitative and quantitative analysis of phytochemical constituents and their metabolites using liquid chromatography–mass spectrometry

Guo

Chen

et al. 2013

Journal of Pharmaceutical and Biomedical Analysis

167

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“…Earlier quality control research of Radix Linderae focused only on quantitative analysis of one or several components [16,17,20,21], but the results were inadequate for the whole quality assurance purposes. Therefore, an integral quality control approach based on the multiple constituents of Radix Linderae is urgently needed to ensure the efficacy and safety of the drug.…”

Section: Introductionmentioning

confidence: 99%

“…The main components of Radix Linderae include sesquiterpenes, sesquiterpene lactones, essential oils [8,9], alkaloids [10,11], flavonoids [12], lignans and condensed tannins [13,14], some of the sesquiterpene lactones and alkaloids have been considered to be characteristic and active constituents and are used as index components for the quality standard of Radix Linderae in Chinese Pharmacopoeia and some articles through quantitative analysis [15][16][17]. The alkaloids in Radix Linderae have showed potential antitumor, antidiabetic, anti-inflammatory, antiviral and antimicrobial activities [18,19].…”

Section: Introductionmentioning

confidence: 99%

Development of the fingerprint for the quality of Radix Linderae through ultra‐pressure liquid chromatography‐photodiode array detection/electrospray ionization mass spectrometry

Zheng

Luan

et al. 2010

J of Separation Science

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An ultra-performance LC in combination with MS/MS method was established to evaluate the quality of wu-yao (the dried root of Lindera aggregata (Sims) Kosterm. (Lauraceae)) through simultaneous quantitation of five sesquiterpene lactones, linderagalactone D (1), linderagalactone C (2), hydroylindestenolide (3), neolinderalactone (4) and linderane (5). All compounds were separated on a Waters Acquity ultra-performance LC HSS T3 column (2.1 mm x 100 mm, 1.8 microm particle size) with linear gradient elution of acetonitrile and 0.1% formic acid. An ESI interface in the positive mode was employed prior to MS detection. All the compounds showed good linearity (R(2)> or = 0.9992). The recoveries, measured at three concentration levels, varied from 97.3 to 103.4% with RSDs < 4.8%. The simple, rapid and reliable method was successfully applied to quantify the five components in 13 samples of wu-yao from different areas.

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“…These instruments are expensive and not popular in every laboratory, especially in wastewater treatment plant (WWTP). Recently, ultra-high-pressure liquid chromatography (UHPLC) has proven to be one of the most promising developments in the area of high-speed chromatographic separations [10,22]. UHPLC uses analytical columns packed with small particles, which offers the advantages of increasing speed, improving sensitivity, selectivity, and specificity compared to conventional HPLC analysis.…”

Section: Introductionmentioning

confidence: 99%

Improved SPE-UPLC-UV-based method for the simultaneous determination of triclocarban and triclosan in wastewater

Liu²,

Wang

2015

Acta Chromatographica

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Summary. Triclocarban (TCC) and triclosan (TCS) are used in a wide range of household and personal care products and have been the most frequently detected organic pollutants in both wastewater and surface water. This paper presented a rapid analytical method for simultaneous determination of TCC and TCS in wastewater. The method involves the extraction and cleanup of the target compounds by using silicon dioxide/polystyrene composite microspheres solid-phase extraction and detection with ultra-high-pressure liquid chromatography. Under the optimized conditions, the limits of detection were 0.028 µg/L and 0.040 µg/L for TCC and TCS, respectively. Under the concentrations of the spiking level ranging from 0.100 µg/L to 2.000 µg/L, the spiked recoveries of TCC and TCS in wastewater samples achieved in the range of 89.5-102.8% with RSD below 6.3% for TCC and 95.5-103.6% with RSD below 6.9% for TCS. This method was successfully used in monitoring the water samples from three traditional wastewater treatment plants.

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Simultaneous determination of four alkaloids in Lindera aggregata by ultra-high-pressure liquid chromatography–tandem mass spectrometry

Cited by 50 publications

References 12 publications

Recent developments in qualitative and quantitative analysis of phytochemical constituents and their metabolites using liquid chromatography–mass spectrometry

Recent developments in qualitative and quantitative analysis of phytochemical constituents and their metabolites using liquid chromatography–mass spectrometry

Development of the fingerprint for the quality of Radix Linderae through ultra‐pressure liquid chromatography‐photodiode array detection/electrospray ionization mass spectrometry

Improved SPE-UPLC-UV-based method for the simultaneous determination of triclocarban and triclosan in wastewater

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