2019
DOI: 10.1016/j.jchromb.2019.121743
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Simultaneous determination of fourteen main active components in Gumiganghwal-tang tablet by using a newly developed UPLC-ESI-MS/MS method

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Cited by 4 publications
(4 citation statements)
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“…As already mentioned in the “ Introduction” section, Gumiganghwal‐tang is a traditional herbal medicine that has been used extensively for centuries. Its main herbal components are A. heterotropoides , A. lancea , and S. baicalensis , which contain asarinin, β‐eudesmol, and wogonin as the main ingredients, respectively (Jeong et al, 2019). Therefore, the method established for the simultaneous analysis of asarinin, β‐eudesmol, and wogonin was extended to a PK study of Gumiganghwal‐tang.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…As already mentioned in the “ Introduction” section, Gumiganghwal‐tang is a traditional herbal medicine that has been used extensively for centuries. Its main herbal components are A. heterotropoides , A. lancea , and S. baicalensis , which contain asarinin, β‐eudesmol, and wogonin as the main ingredients, respectively (Jeong et al, 2019). Therefore, the method established for the simultaneous analysis of asarinin, β‐eudesmol, and wogonin was extended to a PK study of Gumiganghwal‐tang.…”
Section: Methodsmentioning
confidence: 99%
“…The asarinin, eudesmol, and wogonin contents in Gumiganghwal‐tang tablets were analyzed following the procedure reported previously (Jeong et al, 2019). In brief, Gumiganghwal‐tang tablets were ground in a tablet mill (Yu‐Han medical Corp., Daegu, Republic of Korea), and then the powders were sifted into a sieve analyzer by particle size (Fritsch, Idar‐Oberstein, Germany).…”
Section: Methodsmentioning
confidence: 99%
“…16) Our method is comparable to the LC-MS/MS method for Eug, 15) but is less sensitive for MeEug. 14) However, the proposed method does not require expensive instruments and laboratory equipment for sample pretreatment. Additionally, the HPLC-FL method, following derivatization with DIBI, could analyze Eug and MeEug simultaneously, in contrast to the derivatization method with NBD-COCl.…”
Section: Separation Of Dib-derivatives Of Eugsmentioning
confidence: 99%
“…Several analytical methods have been reported for the determination of Eugs, including GC/MS, [7][8][9] HPLC-UV, [10][11][12] liquid chromatography-tandem mass spectrometry (LC-MS/MS), [13][14][15] and enzyme-linked immunosorbent assay (ELISA) 16) methods. Although GC/MS, LC-MS/MS, and ELISA methods are sensitive, sample pretreatment is complicated such as solid-phase extraction for clean-up or the required equipment is expensive.…”
Section: Introductionmentioning
confidence: 99%