Simultaneous Determination of Ranitidine and Metronidazole at Poly(thionine) Modified Anodized Glassy Carbon Electrode

Rahman, Mujibur; Li, Xiaobo; Jeon, Young-Deok; Lee, Ho‐Joon; Lee, Soo Jae; Lee, Jae‐Joon

doi:10.33961/jecst.2012.3.2.90

Cited by 19 publications

(7 citation statements)

References 11 publications

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“…An analytical comparison was performed in Table 6 to show the advanced sensitivity and efficiency of the suggested potentiometric modified sensors for the determination of RNT with other previously reported analytical techniques [ 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 ]. The comparative results showed that the suggested modified sensors using metal oxide nanoparticles exhibited higher sensitivity over a wide concentration range than those reported by the previously developed sensors.…”

Section: Resultsmentioning

confidence: 99%

Ultrasensitive Functionalized Polymeric-Nanometal Oxide Sensors for Potentiometric Determination of Ranitidine Hydrochloride

et al. 2022

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Two metal oxide nanoparticles, magnesium oxide nanoparticles (MgONPs) and aluminum oxide nanoparticles (Al2O3NPs), were synthesized from green sources, Salvia officials and Cuminum cyminum seed extract, respectively. These nanoparticles were used for construction of potentiometric enhancement sensors employed for the estimation of ranitidine hydrochloride (RNT) in authentic powder and commercial products. The electroactive substance ranitidine-phosphotungstate (RNT-PT) was formed by combining RNT with phosphotungstic acid (PTA) in the presence of plasticizing material o-nitrophenyloctyl ether (o-NPOE). The outcomes showed that the enhanced MgO and Al2O3 nanosensors behaved linearly across the concentration ranges 1.0 × 10−9–1.0 × 10−2 and 1.0 × 10−10–1.0 × 10−2 mol L−1, respectively. However, the conventional sensor (RNT-PT) displayed a linearity over 1.0 × 10−6–1.0 × 10−2 mol L−1. Least square equations were calculated as EmV = (54.1 ± 0.5) log (RNT) + 762.33, EmV = (58.6 ± 0.2) log (RNT) + 696.48, and EmV = (52.2 ± 0.7) log (RNT) + 756.76 for enriched nanometal oxides modified and conventional sensors, respectively. The correlation coefficients of regression equations were 0.9997, 0.9995, and 0.9992 for the above suggested sensors, respectively. The recorded results showed excellent sensitivity and selectivity of the modified nanometal oxide sensors for the quantification of the analyzed drug in its authentic samples and commercial products.

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Section: Resultsmentioning

confidence: 99%

Ultrasensitive Functionalized Polymeric-Nanometal Oxide Sensors for Potentiometric Determination of Ranitidine Hydrochloride

et al. 2022

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“…boron-doped diamond(BDD) electrode SWASV À0.977 0.1-4.2 0.065 [39] PTH/GCE DPV À0.550 35-500 0.96 [40] Cu-poly (Cys)/GCE LSV À0.721 0.5-400 0.37 [41] Poly(chromotrope2B)/GCE DPV À0.580 10-400 0.33 [42] CPE a-CD DPV -0.5-103.0 0.28 [43] AgNPs/SF-GR/GCE DPSV -0.1-20.0 0.05 [44] Ni/Fe-layered double hydroxides /GCE CV À0.697 5-1595 58 [45] MWCNTs/CTSÀNi/GCE DPV À0.614 0.1-150 0.025 [37] AgNPs/IL/CA SPCE DPV -3.1-310 310-1300 0.4 [46] Polydopamine/MWCNs-COOHnanocomposites/GCE DPV À0.678 5-300 300-800 800-5000 0.25 [47] Gr-IL/GCE DPV À0.690 0.1-25.0 0.047 [48] MIL 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 detection is 8.3 nM (S/N = 3, n = 10). Likewise, Figure 9b displays the typical DPV response of Pb(II) with increment of its concentrations (0.05 to 7.0 mM) and the linearization equation is I (mA) = 3.985c (mM) + 0.232 (R 2 = 0.9921), with a low detection limit of 6.7 nM (S/N = 3, n = 10).…”

Section: The Simultaneous Detection Of CD 2 + and Pb 2 +mentioning

confidence: 99%

High Performance Electrocatalyst Based on MIL‐101(Cr)/Reduced Graphene Oxide Composite: Facile Synthesis and Electrochemical Detections

Yin

et al. 2018

ChemElectroChem

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In this work, a Cr-based MOF (MIL-101(Cr))/reduced grapheme oxide(rGO) electrocatalyst was prepared through a one-pot hydrothermal method. The obtained composite was characterized via scanning electron microscopy, transmission electron microscopy, X-ray diffraction and other standard techniques. Electrochemical methods were adopted to study the electrocatalytic ability of the composite. The results imply that, compared to the single components, it exhibits higher electrocatalytic activity for the reduction of metronidazole and stripping of Cd 2 + and Pb 2 + . Optimizing the ratio of MIL-101(Cr) and rGO, an electrochemical sensor was prepared using MIL-101 (Cr)/rGO-20 and used for detection of metronidazole, Cd 2 + and Pb 2 + , respectively. The linear range for metronidazole can be divided in two parts, i. e. from 0.5 to 200 mM and from 200 to 900 mM. The limit of detection is 0.24 mM (S/N = 3, n = 10). Likewise, it also exhibits a wide linear range from 0.05 to 6.0 mM for the detection of Cd 2 + and Pb 2 + . The corresponding detection limits are found to be 5.2 nM and 3.0 nM (S/N = 3, n = 10), respectively. The proposed sensor also possesses superb selectivity, reproducibility, stability and can be applied to detect real samples with desired recovery rates. In addition, the possible reduction mechanism of metronidazole and adsorption mechanism of Cd 2 + and Pb 2 + were further discussed simply in this work.[a] J.

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“…RT and MT in pharmaceutical formulations have been determined by spectrophotometry, [10,11] chromatography, [12] atomic absorption spectrometry, [13] near‐infrared reflectance spectrometry, [14] fluorimetric method, [15] titrimetry, [16] flow‐injection chemiluminescence, [17] ion‐selective electrodes, [18] and capillary zone electrophoresis [19] . The lack of selectivity, however, limits their use in pharmacokinetic research in biological and therapeutic specimens.…”

Section: Introductionmentioning

confidence: 99%

“…MT and RT are used together in a combined therapy regimen for the treatment of acute and moderate ulcers in patients who cannot take proton pump inhibitors and 100 mg/mL and 6 mg/mL are their effective plasma concentrations, respectively. [8,9] RT and MT in pharmaceutical formulations have been determined by spectrophotometry, [10,11] chromatography, [12] atomic absorption spectrometry, [13] near-infrared reflectance spectrometry, [14] fluorimetric method, [15] titrimetry, [16] flow-injection chemiluminescence, [17] ion-selective electrodes, [18] and capillary zone electrophoresis. [19] The lack of selectivity, however, limits their use in pharmacokinetic research in biological and therapeutic specimens.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Determination of Ranitidine and Metronidazole at Low Potential Using an Acid‐Activated Glassy Carbon Electrode

et al. 2023

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A simple, highly sensitive and inexpensive electrochemical method was established using an activated glassy carbon electrode (AGCE) in an acidic condition for the determination of ranitidine (RT) and metronidazole (MT) simultaneously at a low potential range. The AGCE was characterized using various techniques such as electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV), and morphology was studied through field‐emission scanning electron microscope (FE‐SEM). The AGCE exhibited an electrocatalytic behavior towards the reduction of RT and MT in 0.5 M acidic solution. Both CV and DPV responses for the mixture of RT and MT gave well‐resolved peaks at low potential. Analysis of these experiments helps us to predict interactions that took place on the surface of AGCE and RT and MT with each other for having different types of functional groups. Furthermore, AGCE also promoted the electron transfer process. The linear dynamic range of MT and RT was 0.5–580 μM and 0.5–500 μM, respectively with the regression coefficient 0.99. The detection limit (S/N=3) calculated for MT and RT was 0.062 μM and 0.13 μM, respectively. Decent results were obtained from the reproducibility and stability test. The performance of the sensor was evaluated for the possible interferences which show high selectivity. Additionally, the real sample analysis was carried out to understand our sensor‘s applicability in real life.

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Simultaneous Determination of Ranitidine and Metronidazole at Poly(thionine) Modified Anodized Glassy Carbon Electrode

Cited by 19 publications

References 11 publications

Ultrasensitive Functionalized Polymeric-Nanometal Oxide Sensors for Potentiometric Determination of Ranitidine Hydrochloride

Ultrasensitive Functionalized Polymeric-Nanometal Oxide Sensors for Potentiometric Determination of Ranitidine Hydrochloride

High Performance Electrocatalyst Based on MIL‐101(Cr)/Reduced Graphene Oxide Composite: Facile Synthesis and Electrochemical Detections

Simultaneous Determination of Ranitidine and Metronidazole at Low Potential Using an Acid‐Activated Glassy Carbon Electrode

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