Simultaneous determination of sulfadiazine, doxycycline, furaltadone and trimethoprim by partial least squares multivariate calibration

Espínosa-Mansilla, A.; Salinas, F.; Orbe-Payá, Ignacio de

doi:10.1016/0003-2670(95)00252-u

Cited by 80 publications

(25 citation statements)

References 15 publications

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“…This software allows validation of the chemometric multivariate calibration by the "full cross-validation." According to this procedure, iterative calibrations were performed by removing in turn each standard from the training set and then predicting the excluded sample with that calibration [17].…”

Section: Hplc As Reference Methodmentioning

confidence: 99%

Simultaneous Quantification of Paracetamol and Caffeine in Powder Blends for Tableting by NIR-Chemometry

Alecu

Tomuță

2017

Journal of Spectroscopy

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Near-infrared spectroscopy (NIRS) is a technique widely used for rapid and nondestructive analysis of solid samples. A method for simultaneous analysis of the two components of paracetamol and caffeine from powder blends has been developed by using chemometry with near-infrared spectroscopy (NIRS). The method development was performed on samples containing 80, 90, 100, 110, and 120% active pharmaceutical ingredients, and near-infrared spectroscopy (NIRS) spectra of prepared powder blends were recorded and analyzed in order to develop models for the prediction of drug content. Many calibration models were applied in order to perform quantitative determination of drug content in powder, and choosing the appropriate number of factors (principal components) proved to be of highly importance for a PLS chemometric calibration. Once the methods were developed, they were validated in terms of trueness, precision, and accuracy. The results obtained by NIRS methods were compared with those obtained by HPLC reference method, and no significant differences were found. Therefore, the NIR chemometry methods were proved to be a suitable tool for predicting chemical properties of powder blends and for simultaneous determination of active pharmaceutical ingredients.

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Section: Hplc As Reference Methodmentioning

confidence: 99%

Simultaneous Quantification of Paracetamol and Caffeine in Powder Blends for Tableting by NIR-Chemometry

Alecu

Tomuță

2017

Journal of Spectroscopy

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“…Various criteria have been developed to select the optimum number (13,14). A cross-validation method leaving out one sample at a time was employed (15). With a calibration set of 25 calibration spectra, PLS-1 and PCR calibrations on 24 calibration spectra were performed, and using this calibration the concentration of the sample left out during the calibration process was determined.…”

Section: Statistical Analysis In Selecting the Number Of Principal Comentioning

confidence: 99%

Simultaneous estimation of ramipril, acetylsalicylic acid and atorvastatin calcium by chemometrics assisted UV-spectrophotometric method in capsules

Sankar¹,

Vetrichelvan²,

Venkappaya³

2011

Acta Pharmaceutica

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In the present work, three different spectrophotometric methods for simultaneous estimation of ramipril, aspirin and atorvastatin calcium in raw materials and in formulations are described. Overlapped data was quantitatively resolved by using chemometric methods, viz. inverse least squares (ILS), principal component regression (PCR) and partial least squares (PLS). Calibrations were constructed using the absorption data matrix corresponding to the concentration data matrix. The linearity range was found to be 1-5, 10-50 and 2-10 µg mL -1 for ramipril, aspirin and atorvastatin calcium, respectively. The absorbance matrix was obtained by measuring the zero-order absorbance in the wavelength range between 210 and 320 nm. A training set design of the concentration data corresponding to the ramipril, aspirin and atorvastatin calcium mixtures was organized statistically to maximize the information content from the spectra and to minimize the error of multivariate calibrations. By applying the respective algorithms for PLS 1, PCR and ILS to the measured spectra of the calibration set, a suitable model was obtained. This model was selected on the basis of RMSECV and RMSEP values. The same was applied to the prediction set and capsule formulation. Mean recoveries of the commercial formulation set together with the figures of merit (calibration sensitivity, selectivity, limit of detection, limit of quantification and analytical sensitivity) were estimated. Validity of the proposed approaches was successfully assessed for analyses of drugs in the various prepared physical mixtures and formulations.

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“…10) The CROSS function performs a cross-validation procedure leaving out one sample at a time. 11,13) It simulates a validation set by leaving out all possible combinations of one spectrum from the training set. The excluded spectrum is treated as an independent validation sample.…”

Section: )mentioning

confidence: 99%

Application of Multivariate Methods to the Simultaneous Fourier Transform Infrared (FT-IR) Spectrometric Determination of Stereo-Isomers; Quinine and Quinidine

Wahbi

Moneeb

Hewala

et al. 2008

CHEMICAL & PHARMACEUTICAL BULLETIN

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Simultaneous determination of sulfadiazine, doxycycline, furaltadone and trimethoprim by partial least squares multivariate calibration

Cited by 80 publications

References 15 publications

Simultaneous Quantification of Paracetamol and Caffeine in Powder Blends for Tableting by NIR-Chemometry

Simultaneous Quantification of Paracetamol and Caffeine in Powder Blends for Tableting by NIR-Chemometry

Simultaneous estimation of ramipril, acetylsalicylic acid and atorvastatin calcium by chemometrics assisted UV-spectrophotometric method in capsules

Application of Multivariate Methods to the Simultaneous Fourier Transform Infrared (FT-IR) Spectrometric Determination of Stereo-Isomers; Quinine and Quinidine

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