Simultaneous Quantification of Paracetamol and Caffeine in Powder Blends for Tableting by NIR-Chemometry

Alecu, Cristian; Tomuță, Ioan

doi:10.1155/2017/7160675

Cited by 13 publications

(4 citation statements)

References 24 publications

(28 reference statements)

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“…It is often combined with analgesics to treat migraine and other headache types. Literature survey reveals that UV [17], Near Infrared spectroscopy [18], HPLC [19][20][21], HPTLC [3] methods have been reported for simultaneous determination and validation of CAF.…”

Section: Introductionmentioning

confidence: 99%

High performance thin layer chromatography (HPTLC) method development and validation for the simultaneous determination of paracetamol, caffeine, chlorpheniramine and phenylepherine in tablet formulation

Arage

Layloff

Hymete

et al. 2023

AChrom

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A rapid, selective, and precise high performance thin layer chromatographic method was developed and validated for the simultaneous analysis of paracetamol, caffeine, phenylephrine and chlorpheniramine in tablets. The chromatographic analysis was carried out on glass plates pre-coated with silica gel 60 F254 as a stationary phase. The optimized mobile phase was methanol : n-butanol : toluene : acetic acid (8:6:4:0.2 v/v). TLC chamber of 10 × 20 cm was used with saturation time of 15 min. The retardation factor (RF) for chlorpheniramine, phenylephrine, caffeine and paracetamol was found to be 0.15 ± 0.02, 0.29 ± 0.02, 0.50 ± 0.02, 0.68 ± 0.02 respectively. Detection was carried out at 212 nm. Validation study was done following ICH Q2 (R1) guideline. The regression data for the calibration plots showed good linear relationship with R 2 = 0.997 over the concentration range of 300–1,500 ng band−1 for caffeine, R 2 = 0.996 over the concentration range of 100–500 ng band−1 for phenylephrine, R 2 = 0.996 over the concentration range of 200–600 ng band−1 for chlorpheniramine, R 2 = 0.998 over the concentration range of 400–2,400 ng band−1 for paracetamol. The method was validated for precision, accuracy and recovery. Minimum detectable amounts were found to be 304.9 ng band−1, 87.88 ng band−1, 117.18 ng band−1 and 143.06 ng band−1 for caffeine, phenylephrine, chlorpheniramine, and paracetamol respectively while the limit of quantification was found to be 923.95 ng band−1, 266.32 ng band−1, 355.11 ng band−1, and 433.53 ng band−1 in the same order. The method was successfully applied to analyze two marketed tablets in a selective and reproducible manner.

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Section: Introductionmentioning

confidence: 99%

High performance thin layer chromatography (HPTLC) method development and validation for the simultaneous determination of paracetamol, caffeine, chlorpheniramine and phenylepherine in tablet formulation

Arage

Layloff

Hymete

et al. 2023

AChrom

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“…Patel et al, 2013b;Phechkrajang et al, 2015;Putri et al, 2021;Sebaiy et al, 2020;2022;V. D. Singh and V. K. Singh, 2021;Vichare et al, 2010), fluorescence spectroscopy (Manouchehri et al, 2016;Salem et al, 2019;Shinde and Divva, 2015;Walash et al, 2011;Zhu et al, 2016), NIR spectroscopy (Manouchehri et al, 2016;Moroni et al, 2022;Muntean et al, 2017;Rahman et al, 2020;Sun et al, 2021) and FTIR spectroscopic method (Rahman et al, 2020). Furthermore, chromatography methods like liquid chromatography (Aminu et al, 2019;74 Eclética Química, vol.…”

Section: Introductionmentioning

confidence: 99%

Development and validation of a new spectrophotometric method for simultaneous determination of sitagliptin and metformin hydrochloride in tablet pharmaceutical dosage forms using chemometrics technique in comparison with HPLC

et al. 2023

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A new, quick, easy, affordable and eco-friendly simultaneous spectrophotometric method for determining a combined sitagliptin and metformin hydrochloride in pharmaceutical formulations was developed and validated using two chemometrics technique. These two methods are the partial least square (PLS) and principal component regression (PCR). They do not need to do a sample preparation or separation before analysis. Various drug concentrations and instrumental spectra of 25 mixed solutions of a combination of sitagliptin and metformin hydrochloride were used for model construction in the range of 200�270 nm. The R2 values of 0.9994 and 0.9996 assigned for the PLS of the sitagliptin and metformin hydrochloride and that of 0.9987 and 0.9996 for the PCR of the sitagliptin and metformin hydrochloride, respectively. It is noteworthy that these two models were successfully and effectively used with the commercial pharmaceutical formulations. Finally, the statistical comparison revealed no significant differences with the results of the HPLC reference method. The proposed method is dependable to be adopted as an alternative analytical method in the pharmaceutical industry�s quality control.

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“…A genetic algorithm based on wavelength selection was also applied for the SMD of caffeine and paracetamol [31]. Some other approaches, such as near-infrared spectrometry [32], flow-injection spectrometry [33], micellar liquid chromatography [34], and micellar electrokinetic capillary chromatography [35] approaches were also proposed for the SMD of caffeine and paracetamol in their dosage forms. Published reports on the SMD of caffeine and paracetamol suggested various analytical approaches for their analysis.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Determination of Caffeine and Paracetamol in Commercial Formulations Using Greener Normal-Phase and Reversed-Phase HPTLC Methods: A Contrast of Validation Parameters

et al. 2022

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There has been no assessment of the greenness of the described analytical techniques for the simultaneous determination (SMD) of caffeine and paracetamol. As a result, in comparison to the greener normal-phase high-performance thin-layer chromatography (HPTLC) technique, this research was conducted to develop a rapid, sensitive, and greener reversed-phase HPTLC approach for the SMD of caffeine and paracetamol in commercial formulations. The greenness of both techniques was calculated using the AGREE method. For the SMD of caffeine and paracetamol, the greener normal-phase and reversed-phase HPTLC methods were linear in the 50–500 ng/band and 25–800 ng/band ranges, respectively. For the SMD of caffeine and paracetamol, the greener reversed-phase HPTLC approach was more sensitive, accurate, precise, and robust than the greener normal-phase HPTLC technique. For the SMD of caffeine paracetamol in commercial PANEXT and SAFEXT tablets, the greener reversed-phase HPTLC technique was superior to the greener normal-phase HPTLC approach. The AGREE scores for the greener normal-phase and reversed-phase HPTLC approaches were estimated as 0.81 and 0.83, respectively, indicated excellent greenness profiles for both analytical approaches. The greener reversed-phase HPTLC approach is judged superior to the greener normal-phase HPTLC approach based on numerous validation parameters and pharmaceutical assays.

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Simultaneous Quantification of Paracetamol and Caffeine in Powder Blends for Tableting by NIR-Chemometry

Cited by 13 publications

References 24 publications

High performance thin layer chromatography (HPTLC) method development and validation for the simultaneous determination of paracetamol, caffeine, chlorpheniramine and phenylepherine in tablet formulation

High performance thin layer chromatography (HPTLC) method development and validation for the simultaneous determination of paracetamol, caffeine, chlorpheniramine and phenylepherine in tablet formulation

Development and validation of a new spectrophotometric method for simultaneous determination of sitagliptin and metformin hydrochloride in tablet pharmaceutical dosage forms using chemometrics technique in comparison with HPLC

Simultaneous Determination of Caffeine and Paracetamol in Commercial Formulations Using Greener Normal-Phase and Reversed-Phase HPTLC Methods: A Contrast of Validation Parameters

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