Simultaneous Determination of Tobacco Alkaloids, Tobacco-Specific Nitrosamines, and Solanesol in Consumer Products Using UPLC–ESI-MS/MS

Shifflett, John R.; Watson, Leah; McNally, Devin J.; Bezabeh, Dawit Z.

doi:10.1007/s10337-017-3462-4

Cited by 10 publications

(2 citation statements)

References 9 publications

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“…Also, LC-MS/MS is capable of detecting NNN and NNK within a short analysis time [29,[31][32][33]. To date, an analysis method for EC solution using an LC-MS/MS system has been proposed by a limited number of study groups (e.g., [34][35][36][37]). Moreover, there are only a few reported analytical methods for the measurement of TSNA concentration levels in EC aerosols.…”

Section: Introductionmentioning

confidence: 99%

Analytical Method for Measurement of Tobacco-Specific Nitrosamines in E-Cigarette Liquid and Aerosol

et al. 2018

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An experimental method was developed and validated for the collection and analysis of tobacco-specific nitrosamines (TSNAs) that are present in electronic cigarette (EC) liquid or are released from aerosol samples using a liquid chromatography-tandem mass spectrometry (LC-MS/MS) system. As part of this study, the relative recovery of four target TSNAs was assessed by spiking standards in a mixture of propylene glycol and vegetable glycerin. Recovery was assessed against two major variables: (1) the chemical media (solution) selected for sample dilution (acetonitrile [ACN] vs. ammonium acetate [AA]) and (2) the type of sampling filter used (Cambridge filter pad [CFP] vs. quartz wool [QW] tube). The average recovery of TSNAs in terms of variable 1 was 134 ± 22.1% for ACN and 92.6 ± 8.27% for AA. The average recovery in terms of variable 2 was 83.4 ± 7.33% for QW and 58.5 ± 12.9% for CFP. Based on these conditions, the detection limits of N′-nitrosonornicotine (NNN), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), N′-nitrosoanatabine (NAT), and N′-nitrosoanabasine (NAB) were calculated as 4.40, 4.47, 3.71, and 3.28 ng mL−1, respectively. The concentration of TSNAs in liquid and aerosol samples of six commercial EC solutions was measured as below the detection limit.

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Section: Introductionmentioning

confidence: 99%

Analytical Method for Measurement of Tobacco-Specific Nitrosamines in E-Cigarette Liquid and Aerosol

et al. 2018

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“…Some analytical methods have been proposed in the literature for the analysis of myosmine from different media; GC/MS, gas chromatography/mass spectrometry [4]; LC‐MS/MS, liquid chromatography/tandem mass spectrometry [6]; GC‐MS/MS, gas chromatography/tandem mass spectrometry [7]; HPLC‐UV: high performance liquid chromatographic‐UV detection [8]; UPLC‐ESI‐MS/MS: ultra performance liquid chromatography with electrospray ionization‐tandem mass spectrometric detection [9]. These studies are summarized in Table 1 with their analytical features.…”

Section: Introductionmentioning

confidence: 99%

Firstly Electrochemical Examination of Myosmine at Glassy Carbon Electrode: Sensitive Determination in Tobacco Leaves by Differential Pulse Voltammetry

et al. 2021

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In this study, the electrochemical properties of myosmine, one of the tobacco alkaloids, were investigated for the first time using cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques on glassy carbon electrode (GCE). Using GCE with CV technique, it gave an irreversible reduction peak with diffusion control at about −1.38 V in Britton‐Robinson (BR, pH 12.0) medium. A good linear relationship between concentration and current in the range of 0.5 μM–3.5 μM in BR (pH 12.0) medium on GCE with DPV technique [Ip(μA)=0.847 C(μM)+0.114, r=0.995, n=7] has been observed. The proposed method has been successfully applied to tobacco leaves.

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Use of autoclave extraction-supercritical fluid chromatography/tandem mass spectrometry to analyze 4-(methylintrosamino)-1-(3-pyridyl)-1-butanone and N’-nitrosonornicotine in tobacco

Deng

Tang

Fan

et al. 2019

Journal of Chromatography A

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Simultaneous Determination of Tobacco Alkaloids, Tobacco-Specific Nitrosamines, and Solanesol in Consumer Products Using UPLC–ESI-MS/MS

Cited by 10 publications

References 9 publications

Analytical Method for Measurement of Tobacco-Specific Nitrosamines in E-Cigarette Liquid and Aerosol

Analytical Method for Measurement of Tobacco-Specific Nitrosamines in E-Cigarette Liquid and Aerosol

Firstly Electrochemical Examination of Myosmine at Glassy Carbon Electrode: Sensitive Determination in Tobacco Leaves by Differential Pulse Voltammetry

Use of autoclave extraction-supercritical fluid chromatography/tandem mass spectrometry to analyze 4-(methylintrosamino)-1-(3-pyridyl)-1-butanone and N’-nitrosonornicotine in tobacco

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