2019
DOI: 10.1016/j.chroma.2019.02.053
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Use of autoclave extraction-supercritical fluid chromatography/tandem mass spectrometry to analyze 4-(methylintrosamino)-1-(3-pyridyl)-1-butanone and N’-nitrosonornicotine in tobacco

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Cited by 4 publications
(2 citation statements)
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“…As a consequence, it is uncertain about the extraction efficiency for MH residues, especially lignin incorporated MH. Lang and Vuarnoz reported the accelerated release of lignin incorporated tobacco specific N ‐nitrosamine, 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanone, in static pressurized hot water extraction condition (autoclave extraction), this was also demonstrated in our recent study . Motivated by these interesting findings, we proposed the use of autoclave extraction and LC–MS/MS for efficient extraction and determination of MH residues in tobacco in the present work.…”
Section: Introductionsupporting
confidence: 65%
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“…As a consequence, it is uncertain about the extraction efficiency for MH residues, especially lignin incorporated MH. Lang and Vuarnoz reported the accelerated release of lignin incorporated tobacco specific N ‐nitrosamine, 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanone, in static pressurized hot water extraction condition (autoclave extraction), this was also demonstrated in our recent study . Motivated by these interesting findings, we proposed the use of autoclave extraction and LC–MS/MS for efficient extraction and determination of MH residues in tobacco in the present work.…”
Section: Introductionsupporting
confidence: 65%
“…Since MH presents as free MH, glucose‐MH conjugates, and lignin bound MH in tobacco, aggressive extraction conditions are required to fully extract MH. Both caustic and acidic conditions at elevated temperatures have shown to work well and also have the added benefit of hydrolyzing the glucoside conjugates in the process. However, in the reported acidic extraction procedures, various extraction approaches were employed, including heating reflux, sonication, and microwave assisted extraction.…”
Section: Resultsmentioning
confidence: 99%