Simultaneous high-performance liquid Chromatographic determination of carboplatin, epirubicin hydrochloride and mitomycin C in a Lipiodol emulsion

HPLC method for the determination of carboplatin and paclitaxel with cremophorEL in an amphiphilic polymer matrix

“…It possesses broad antineoplastic activity. Development of a method by RP-HPLC was difficult owing to its extreme hydrophilicity; it has minimal k values on most ODS columns and is hence not retained on RP-based cartridges and it does not get partitioned extensively into water immiscible solvents [6,7]. Reported methods of analysis of platinum analogs are based upon atomic absorption (flame and nonflame) [8], inductively coupled plasma atomic emission (ICP-AE) [9], electroanalytical techniques [10], neutron activation analysis [11] and gas [12] and normal phase liquid chromatography [13].…”