Simultaneous high-performance liquid chromatographic determination of theophylline, ephedrine hydrochloride, and phenobarbital in tablets

A three-solvent system was used to determine the Hildebrand solubility parameters of organic nonelectrolytes. The experimental Hildebrand solubility parameter represents a weighted average of the mole fraction solubilities of the solute in these three individual solvents (ethyl acetate, 1-propanol, and 1,2-propanediol). The solvent system estimated the Hildebrand solubility parameters of solutes within a range from 8.9 to 14.8 (cal/cm3)2(1). Deviations ranged from 0.8 to 12.9%, with the highest value at the extreme and well within 10% at the median. Estimation of the Hildebrand solubility parameters of solutes within a wider range and with somewhat better accuracy was made with a five-solvent system (hexane, ethyl acetate, 1-propanol, 1,2-propanediol, and water).

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Analyse par chromatographie liquide haute performance ultra-rapide de la théophylline et de l'anisate de sodium (ou de potassium) dans différentes préparations pharmaceutiques

Thomas¹

1989

Journal of Chromatography A

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Simultaneous high-performance liquid chromatographic determination of theophylline, ephedrine hydrochloride, and phenobarbital in tablets

Cited by 10 publications

References 9 publications

An Experimental Method for Determining the Hildebrand Solubility Parameter of Organic Nonelectrolytes

An Experimental Method for Determining the Hildebrand Solubility Parameter of Organic Nonelectrolytes

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Analyse par chromatographie liquide haute performance ultra-rapide de la théophylline et de l'anisate de sodium (ou de potassium) dans différentes préparations pharmaceutiques

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